Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"centrosome clustering"”.
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Production of recombinant monoclonal antibodies against HSET
… kinesin 14A family, is a protein required for centrosome clustering during cell division. Since cancer cells with extra-centrosomes could lead to multi-polar division, resulting in genomic instability and cell death, these cancer cells depend on the centrosome clustering activity of HSET that …
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SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS
… may underly a role of polo-like kinase 1 in centrosome clustering and PPP2R5D as part of the protein phosphatase 2A complex works with polo-like kinase 1 to maintain chromosome segregation, which may be exploited as a therapeutic approach. The highly validated set of therapeutic targets in …
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Mathematical modeling of biological dynamics
… bipolarity from the irregular forms caused by centrosome defects/perturbations. By developing a biophysical model based on experimental data, we uncover the mechanisms that guide the separation and/or clustering of centrosomes. Our model identifies key biophysical factors that play a critical …