Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"centrosome amplification"”.
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Consequences of Plk4 overexpression in mouse pancreatic organoids
… kinase 4 (Plk4), the master regulator of centrosome duplication, leads to centrosome amplification, a common feature of cancer, including pancreatic cancer. Previous studies have shown that overexpression of Plk4 in mice carrying a doxycycline-inducible Plk4 transgene (Plk4OE) causes …
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The chronic response to centrosome loss-induced cell cycle exit
The centrosome is a membrane-less organelle which primarily functions as a microtubule organising centre in eukaryotic cells, to allow normal progress through the cell cycle. While centrosome amplification in the absence of p53 is a well-established feature of cancers, more recently centrosome loss …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
The centrosome serves as the main microtubule-organizing center (MTOC) in animal cells, orchestrating essential processes such as spindle assembly and cell cycle progression. Centrosome amplification and cytokinesis failure are hallmarks of genomic instability, often observed in precancerous …
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Biomarkers of Genome Instability and Disease Progression in Ovarian Cancer
… thesis, we aim to investigate the prevalence of centrosome abnormalities in HGSOC and their involvement in driving CIN. The centrosome is the main microtubule organising centre of a cell and plays a crucial role during cell division ensuring accurate chromosome segregation. Missegregation of …
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The evolution of centrosome and chromosome number in newly formed tetraploid human cells
… also confer cells with double the number of centrosomes, the small membraneless organelle that organizes the cell's microtubule cytoskeleton and mitotic spindle apparatus. Centrosome number homeostasis is crucial for health, and recent studies have shown inducing extra centrosomes in cells …