Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"central sensitization"”.
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Secondary Traumatic Stress Promotes Central Sensitization of the Trigeminal System
… nervous system involving peripheral and central sensitization of trigeminal nociceptive nerves. Since migraine is often comorbid with temporomandibular joint disorder and inflammatory bowel disease, it is associated with significant social and economic burdens. Primary traumatic stress is …
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The role of Substance P and its signaling pathways in central sensitization
Central sensitization of nociceptive dorsal horn neurons is an underlying mechanism of behavioral phenotype, such as secondary hyperalgesia. Substance P (SP) is regarded as an important neuropeptide and mainly exists in primary afferent fibers in the superficial dorsal horn. Release of SP in the …
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Investigation of Offset Analgesia during Acute Central Sensitization, Opioid Administration and Complex Regional Pain Syndrome
… was assessed in healthy volunteers during acute sensitization by topical capsaicin, however, no alterations in offset analgesia by capsaicin-heat sensitization were observed. Second, since opioid mechanisms may play a role in offset analgesia, real-time intensity ratings were assessed in healthy …
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Critical role of ROS in capsaicin-induced hyperalgesia
… mechanisms, thus suggesting ROS involvement in central sensitization. To investigate ROS involvement in central sensitization, the effects of ROS scavengers and donors on pain behaviors were examined in mice. The capsaicin-induced hyperalgesia was used as a pain model since it has 2 distinctive …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… disorder is characterized by peripheral and central sensitization of trigeminal nociceptive neurons. Although CGRP is implicated in the development of central sensitization by stimulating glial activation via its receptor, the mechanism by which CGRP promotes and maintains sensitization of …
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Investigation of Nocifensive and Cellular Effects of Dihydroergotamine in a Model of Chronic Migraine
… signaling protein PKA, which is known to promote central sensitization, and Iba1, a marker of activated microglial cells. However, both DHE and sumatriptan were able to inhibit stimulated levels of GFAP, a protein used as a marker of activated astrocytes. Results from my study provide evidence …
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Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine
… and other somatic symptoms. Prolonged sensitization of the trigeminal system, which is implicated in CM, is comprised of peripheral primary trigeminal ganglion neurons that provide sensory innervation of the head and face and second order neurons in the spinal trigeminal nucleus (STN). …
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Individual Differences in Secondary Hyperalgesia and Associated Neural Activity
… its underlying mechanisms (Nijs et al., 2021). Central sensitization is a mechanism associated with chronic pain, and secondary hyperalgesia is a manifestation of central sensitization that reflects pain felt beyond the site of the injury (Nijs et al., 2021; Woolf, 2011). Secondary hyperalgesia …
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… results in both loss of function and chronic central pain syndromes. In the clinical population, pain is characterized based on anatomical location: 1) Below-level pain – located at dermatomes corresponding to spinal segments caudal to the injury site, 2) At-level pain – located at dermatomes …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
… neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. Oxidative stress due to excessive levels of reactive oxygen species (ROS) has been implicated in the development and maintenance of neuropathic pain. However, it is not …
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Central Role Of CGRP And Protein Kinase A In Promoting Trigeminal Sensitization In An In Vivo Model Of Temporomandibular Joint Disorder
… nociceptive neurons that promote peripheral sensitization and excitation of second order neurons implicated in the development of central sensitization and hyperalgesia. Elevated levels of the neuropeptide calcitonin gene-related peptide (CGRP) in the joint capsule and upper spinal cord are …
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Functional Connectivity Within the Dynamic Pain Connectome Underlying Inter-Subject Differences in Acute and Chronic Pain
… found that healthy individuals who had greater central sensitization, had an imbalance towards stronger functional connectivity within their ascending nociceptive compared to descending pain-modulatory pathway. In response to a similar level of pain delivered during the performance of a …
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TWO TYPES OF ROS ARE DIFFERENTIALLY INVOLVED IN SPINAL SYNAPTIC PLASTICITY AND MECHANICAL HYPERSENSITIVITY IN NEUROPATHIC PAIN
Central sensitization, characterized by an increase in dorsal horn synaptic efficacy, is believed to underlie the chronic nature of neuropathic pain. It has been shown that pain-relaying synapses in the dorsal horn express two forms of long term changes in excitability––long term potentiation (LTP) …
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People with chronic non-cancer pain receiving chronic morphine treatment at the Chronic Pain Management Clinic of Groote Schuur Hospital: a cross-sectional survey of characteristics and satisfaction with treatment
… health status, health-related quality of life, central sensitization, and satisfaction with their treatment. Results The majority of our patients were older, overweight, currently unemployed, and from low socioeconomic status. Patients reported an overall severe pain severity score of 7 (IQR: …
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Role of Central Sensitivity Syndromes in women with pelvic organ prolapse
Title- Role of Central Sensitivity Syndromes in Women with Pelvic Organ Prolapse. Author- Monika Vij Pelvic Organ Prolapse (POP) is a dysfunction of pelvic floor support and have an ad-verse effect on the quality of life (QOL). The predominant symptom is the feeling of a vaginal bulge. However, a …
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Plasticity in mice nociceptive spinal circuits -role of cell adhesion molecules.
… that the current view on the locus of the central sensitization mechanisms needs to be reconsidered. In the second part of the thesis, the role of the cell adhesion molecule L1 in the pain system was studied in mutated mice. Interestingly, these animals were found to be almost analgesic. …
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Development and Characterization of a Mechanically Induced Temporomandibular Joint Disorder
… jaw opening for 20 minutes results in sustained sensitization of trigeminal nociceptive neurons by a mechanism that likely involves increased expression of cytokines within the spinal trigeminal nucleus.