Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 404 for “"central nervous system (CNS)"”.
-
Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
Introduction: Paediatric central nervous system (CNS) infections are associated with high mortality rates and neurological disability in survivors due to brain injury caused by cerebral inflammation. Because the brain is difficult to study, the unique characteristics of the neuroinflammatory …
-
Epidemiological Features of Central Nervous System (CNS) Infections in Taiwan and Molecular Investigation of CNS Infections of Unknown Cause
… I explore the epidemiological features of CNS infections using a population-based dataset and analyze CSF samples from patients with meningitis or encephalitis of unknown cause using molecular methods. In the second chapter, I review the literature on the epidemiology of meningitis and …
-
Behavioral and Neurochemical Effects of Neonatal Administration of Monosodium L-Glutamate in the Mouse.
… observation served to focus attention on the central nervous system (CNS) as the site of systems that regulate food intake.
-
The ghrelin system links dietary lipids with the endocrine control of energy homeostasis
… hormone. It activates orexigenic circuits in the central nervous system (CNS) when acylated with a fatty acid residue by the Ghrelin O-acyltransferase (GOAT). Soon after the discovery of ghrelin a theoretical model emerged which suggests that the gastric peptide ghrelin is the first “meal …
-
A biochemical investigation into aspects of the neuro active amino acid receptor complexes in the insect nervous system
… and aminobutyric acid (GABA) receptors in the central nervous system (CNS) of the American cockroach, Periplaneta americana. The aim was to provide a simple, quick and cost effective method of screening new chemical entities as potential insecticides acting on these systems, and to provide …
-
Neural precursor identity, cell division, and evolution in the insect central nervous system
A central challenge for every organism is the generation of cell diversity during development. How does a single cell, the fertilized egg, give rise to the vast array of specialized cell types found in a mature organism? A related question is how has development evolved to generate diversity among …
-
CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic …
-
The synthesis and pharmacology of some novel excitatory amino acid analogues
… as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These receptors have been named after the most potent and selective agonist of each; thus they are …
-
Investigation of neural correlates of bladder control using functional magnetic resonance imaging (fMRI) in patients with overactive bladder (OAB)
… this research is to determine whether there are Central Nervous System (CNS) differences in modulating bladder function that contribute to, or are themselves the cause of the symptoms in OAB patients. We further investigated the pharmacological fMRI changes
-
Neurobehavioral and neurochemical effects of ortho-substituted polychlorinated biphenyl congeners in perinatally exposed rats
… chain. PCB exposure during development of the central nervous system (CNS) results in behavioral dysfunction and impaired learning and memory. There are two major classes of PCBs, coplanar and ortho-substituted (OS) congeners. Most of the PCBs in environmental mixtures are the OS congeners. In …
-
The neuropsychological and behavioural profiles of HIV-infected asymptomatic HAART-naïve children : a cross sectional and follow-up study
… of pediatric HIV infection is its impact on the central nervous system (CNS). Children born with HIV may present with cognitive abnormalities within a few months or years of birth. However, there is a group of children known as ‘slow progressors’ or asymptomatic children who do not exhibit …
-
Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant
… Toxic effect of lead are mainly manifested in central nervous system (CNS) because brain acts as a reservoir for lead deposition. Lead-induced cell damage include glutamatergic component (excitotoxic cell damage arising from impaired clearance of the released glutamate), interference with …
-
Caffeine's influence on critical flicker frequency thresholds
Caffeine's effect on the visual system was investigated. Twelve male and twelve female subjects (aged 18 - 25 years) were measured for Critical Flicker Frequency (CFF) thresholds at 15 levels of retinal illuminance (-1.0 to 3.0 log trolands) in each of four caffeine dosage conditions (0, 200mg, …
-
OPPOSING ROLES OF THE μ-OPIOID AND NOCICEPTIN/ORPHANIN FQ RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT AND MYELINATION
… regulators of plasticity and remodeling in the central nervous system (CNS). Thus, OLG maturation and myelination are highly vulnerable processes along CNS development. We previously showed that rat brain myelination is altered by perinatal exposure to buprenorphine, an opioid analogue in …
-
FUNCTIONAL ANALYSIS OF ANAPLASTIC LYMPHOMA KINASE DURING EMBRYONIC NEUROGENESIS IN ZEBRAFISH
… of alk. Zebrafish alk is highly expressed in the central nervous system (CNS) during embryonic development. Constitutive overexpression of non-mutated alk in a heat shock inducible transgenic zebrafish line resulted in ectopic MAPK activation, elevated cell proliferation, disruption of …
-
EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
… are the main form of immune defence in the central nervous system (CNS). Microglia express phosphatidylinositol 3-kinase (PI3K), shown to play a significant role in synaptic plasticity in neurons. This study shows that the microglial PI3K/AKT pathway is epigenetically regulated through miRNA …
-
Neuromuscular responses to an isometric force and position task during passive hyperthermia
Mechanisms of central nervous system (CNS) impairment during hyperthermia are largely task-dependent. This thesis sought to compare neuromuscular responses of an isometric force and position task during passive hyperthermia, and the relative contributions of rectal (Tre) and skin (T ̅sk) …
-
Investigating the effects of aging and the neuromodulator retinoic acid on neurite outgrowth in a novel CNS organ culture
Neurite outgrowth is a critical process for nervous system regeneration following injury. However, aging impairs this process through changes in calcium handling, neurotransmitter sensitivity, and energy metabolism. In this thesis, I investigated agerelated changes in neurite outgrowth using a …
-
Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
… fluids and solutes between the parenchyma of the central nervous system (CNS) and perivascular spaces. We hypothesized that activation of AQP4 may mediate permeability of the CNS during systemic inflammation. Here, mice were i.v. injected with fluorescent tracers of low (1 kd) and intermediate (10 …
-
Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation
… induces recovery in animal models of central nervous system (CNS) diseases, in part by modulating adaptive and innate immune responses. Since metabolism governs the phenotype and function of immune cells, the aim of this thesis was to investigate whether NSCs have the ability to …
Page 1 of 21