Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1216 for “"central nervous system"”.
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Cell biomechanics of the central nervous system
… level. In order to understand how cells of the central nervous system (CNS) respond to mechanical insults and stimuli, a combined modeling/experimental approach was adopted. A computational framework was developed to accurately model how cells deform under various macroscopically imposed loading …
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Axon-glia interactions during central nervous system myelination
Myelination drastically speeds up action potential propagation along axons, which is fundamental for the correct function of neuronal circuits. However, axon-oligodendrocyte interactions regulating the onset of myelin formation remain unclear. I sought to determine how reticulospinal axons control …
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Alginate-based Hydrogels for Central Nervous System Tissue Regeneration
As the central nervous system shows very little capability for self-repair following injury, regenerative medicine approaches are increasingly interested in the use of stem cells for cell replacement strategies. Biomaterials are an interesting tool to carry out this type of therapies. They allow …
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Spontaneity and Precision in the Drosophila Central Nervous System
… might provide insight into how a heading system can store an angular memory in complete darkness, without significant drift, for many minutes.</p>
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
Aniridia, a congenital ocular disorder caused by haploinsufficiency of transcription factor PAX6, is characterized by complete or partial iris hypoplasia with associated foveal hypoplasia. Brain imaging performed in patients heterozygous for PAX6 mutations often reveal absence of the brain anterior …
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Functional Characterization of Neurexophilins in the Central Nervous system
In der vorliegenden Arbeit wurde die Lokalisation und Funktion von Neurexophilinen mittels eines neurogenetischen Ansatzes im Gehirn von Mäusen untersucht. Neurexophiline (Nphs) konstituieren eine Proteinfamilie von Glykoproteinen, die ursprünglich als eine Komponente der alpha-Neurexine isoliert …
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On the chemical dynamics of the central nervous system
Title page, contents and abstract only. The complete thesis in print form is available from the University Library.
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Promoting Central Nervous System Regeneration by Targeting Intracellular Pathways
Adult central nervous system neurons regenerate poorly after injury. One reason for this regenerative failure is that a developmental change occurs where essential growth-molecules become excluded from axons with maturation. In this thesis, two strategies were employed in order to improve axon …
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A survey of central nervous system diseases of Michigan cattle
Thesis (M.S.)--Michigan State University. Dept. of Pathology, 1973
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CRISPR-based approaches for proteinopathies of the central nervous system
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Transcriptional regulators of nestin in the rat central nervous system
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Biomaterials for protection and repair of the central nervous system
An injectable hydrogel for controlled release of methylprednisolone was designed based on the inflammatory response during acute spinal cord injury. The gel is injectable through a small gauge needle, cross-links under physiological conditions, and releases methylprednisolone over a time period on …
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… encephalitis due to their ability to invade the central nervous system (CNS), and the most common cause is HSV-1. Inborn errors of immunity (IEIs) have demonstrated that neuron, cell type-specific, antiviral immunity is essential to prevent viral infection and encephalitis. However, despite these …
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Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… whether SRF participates in earlier aspects of central nervous system development such as neuronal projection establishment, cell-fate specifications, and neural stem cell homeostasis and survival. We report that SRF is critical for development of major axonal tracts in the forebrain. …
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Transcriptional Regulation of Neuronal Differentiation in the Drosophila Central Nervous System
The central nervous system is the most complex and highly organized tissue in animals; composed of thousands of neurites connected in specific and highly reproducible ways. My thesis research has focused on the generation of neuronal diversity: specifically how neurons adopt individual, often …
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Relationship Between CB1 and S1P Receptors in the Central Nervous System
… possible relationships between these two systems at the level of G-protein activation, agonist-stimulated [35S]GTPγS binding and autoradiography were conducted. Autoradiographic studies were first performed to localize receptor-mediated G-protein activation in mouse brain. Coronal brain …
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Immunohistochemical characterization of neuronal cilia in the rat central nervous system.
… used to label neuronal cilia throughout the rat central nervous system. Immunoreactive cilia were observed in every examined region of the rat CNS, but not in monkey or mouse tissue. Antibodies to G"q and G"q/11 failed to label cilia. Immunoreactive cilia were observed as early as postnatal day 0 …
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Nitric oxide induces chromatin remodelling in the developing central nervous system
The development of the nervous system is a complex task that involves precise connections between billions of neurons. This is achieved, at least in part, by the overproduction of neurons and the survival of a select few that compete for limited survival and growth promoting factors, such as …
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Interactions between anticholinesterases in an in vitro central nervous system preparation
… causing overstimulation within the cholinergic nervous system. If left untreated, this can be fatal. Current medical countermeasures to nerve agent poisoning consist of pretreatment with pyridostigmine and an emergency therapy comprising atropine, diazepam and pralidoxime. As well as a …
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