Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 208 for “"cellular uptake"”.
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Toxicology of nanoparticles after cellular uptake
Nanoscience is a multi-disciplinary field with the potential to both create new applications and understand existent systems, but its materials may be sources of toxicological concern. Understanding their toxic potential becomes essential to prevent any occupational, environmental, and consumer …
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Manipulating PLGA nanoparticle cellular uptake and trafficking
… preventing antibiotic activity. Several extracellular bacterial pathogens including P. aeruginosa, S. aureus, and K. pneumonia can invade, survive, and reproduce inside human cells. Therefore, finding effective treatments to eradicate these intracellular bacterial infections is critical. <br/> …
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Smart Cell-Penetrating Peptides. Strategies to regulate cellular uptake
Contains fulltext : 157591.pdf (Publisher’s version ) (Open Access)
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Cellular uptake and biological activity of synthetic hammerhead ribozymes
… stability and a fundamental understanding of cellular uptake mechanisms. Chimeric 2'-O-methylated hammerhead ribozymes proved to be significantly more stable (>4000-fold) in serum than unmodified RNA ribozymes and exhibited high in vitro catalytic activity. The cellular association of an …
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Cellular Uptake of Neutrohpil Elastase Links Inflammation to Adaptive Immunity
… primarily to its ability to degrade the extracellular matrix thereby promoting invasion and metastasis. Recently, it was shown that NE could be taken up by lung cancer cells leading to degradation of insulin receptor substrate-1 thereby promoting hyperactivity of the phosphatidylinositol-3 …
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Gold nanoparticle cellular uptake and its implications for cancer therapy
… from such treatment a full understanding of the uptake dynamics of nanoparticles is required. As such the aim of this body of work is to conceptualise and experimentally demonstrate novel approaches to probe the uptake of gold nanoparticles (AuNPs) in cancer cells. <br/><br/>In the first study a …
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Cellular uptake and actions of bilberry anthocyanins in retinal pigment epithelial cells
… to treat AMD. It is not clear whether intracellular concentrations of anthocyanins are sufficient to quench radical species and mitigate oxidative stress in vivo. In this research project, human RPE cells in vitro were used to establish an oxidative stress model in which the effects of …
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The <em>In Vitro</em> Cellular Uptake and Physiochemical Properties of Tocotrienols.
… includes two parts. The first part concerns the uptake and growth inhibition of tocotrienols in PC-3 cells. The second part is a study of the physiochemical properties of Vitamin E.</p><p>In the cellular study our results suggested that position 5 of chroman head and side-chain are very important …
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Synthesis, Characterization and Cellular Uptake of Magnesium Complexes of Pyrones and Amino Acids
… emphasis placed on determining the in vitro uptake of all produced complexes. This work aims to mitigate the shortcomings of current magnesium supplements and better illustrate an understanding of the factors impacting magnesium uptake. Specifically, 1) There is a paucity of information …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of …
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Tailoring electrospun nanofibers and electrosprayed nanoparticles to enhance cellular uptake of low bioavailability drugs
… nanoparticles were tailored to enhance cellular uptake of low bioavailability drugs (hemin). DMF and MeOH was used to make hemin soluble. PVP-360 and eudragit L 100 were initially selected to make hemin formulations by electrospinning. A variety of electrospinning conditions were …
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Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor
… to excert its enzyme inhibiting functions extracellularly, as a defense against enzymes from leaking lysosomes or invading pathogens. It was demonstrated by various techniques, including flow cytometry, confocal microscopy, ELISA and Western blotting, that cystatin C was internalised in cells of …
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Synthesis, characterization, and anticancer evaluation of novel gold(I) phosphine thiolate complexes : solubility, cellular uptake, and cytotoxicity.
… cells, particularly in the absence of DMSO. Cellular uptake studies in MCF-7 cells, using different drugs and media without additional cells introduced demonstrated a positive correlation between solubility in growth media and the amount of gold accumulated within cells, linking a compounds …
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In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles
Cancer is the collective group of diseases distinguished by uninhibited growth and spread of abnormal cells. It often results in death if the spread is not controlled. Most cancers are treated by surgery, radiation, chemotherapy, hormones, or immunotherapy. However, currently there are many issues …
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Mechanisms of Accumulation and Biological Consequences of Polynuclear Platinum Compounds
… and been shown to have greater cytotoxicity and cellular uptake than clinical anticancer platinum drugs such as cisplatin, oxaliplatin and carboplatin. The clinical efficacy of cisplatin, oxaliplatin and carboplatin is limited due to acquired resistance and dose limiting side effects. The three …
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Investigation of a fusogenic pH-sensitive liposomal system for tumour-targeted intracellular delivery of dinitrobenzamide mustard prodrugs
… poor water solubility, short half-life and poor cellular uptake, limits their potency. In drug delivery, nano-sized PEGylated pH-sensitive liposomes (pPSL) have been investigated as an effective drug carrier (and solubiliser) to confer improved tumour targeting. pPSL containing …
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Cyclic and Linear Cell-Penetarating Peptides Composed of Tryptophan (WW) and Arginine (RR) Residues as Molecular Transporters
… (R) amino acids [WR]<sub>5</sub> have higher cellular uptake than the corresponding linear peptides and can act as molecular transporters. Herein we report the synthesis of linear and cyclic peptides containing alternate WW and RR residues and the evaluation of their cytotoxicity, cellular …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… of 1 µM and after 3 h of incubation time. The uptake of fluorescence-labeled cargo molecules (F′-GpYEEI, F′-AMpYSSV, F′-siRNA, and F′-d4T) in the presence of the peptides was monitored in different cell lines (MDA-MB-231and SK-OV-3) with FACS. Among all the peptides, (RWRW3)2 showed the highest …
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