Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"cellular transport"”.
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TB-RBP protein : sitting at the crossroads of sex and disease
… 1 and 2), attach mRNAs to microtubules for cellular transport of brain mRNAs and to mediate both temporal and spatial expression of certain mRNAs in male germ cell development. Translin is the human homologue of mouse TB-RBP. Translin is proposed to function as a DNA-binding protein that …
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Statistical imaging of transport in complex fluids: a journey from entangled polymers to living cells
… of statistical mechanics, we studied several transport phenomena in complex fluids with nanometer and millisecond resolution. On the list are diffusion of nanoparticles and vesicles in crowded environments, reptational motion of polymers in entangled semidilute solutions, and active endosome …
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Intraorgan lymphatics with special reference to the pancreas
… of the vessels and on the width of the intercellular junctions. Such information is necessary to understand the cellular transport mechanisms responsible for lymph formation.
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Modulation of drug transport by citrus fruit juices
Fruit juice-drug interactions involving drug transporters have been variously studied with citrus fruit juices. The collective data led us to hypothesize that the modulating activity of citrus fruit juices on cellular transport and metabolic pathways is dependent on the dominant flavonoid pattern …
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Differential expression profiling of proteomes of pathogenic and commensal strains of Staphylococcus aureus using SILAC
… These proteins are involved in a variety of cellular functions, including immune modulation, iron-binding, cellular transport, redox reactions, and metabolic enzymes. The differentially expressed proteins can serve as putative candidates to improve current approach towards development of a …
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Single-cell differential splicing of Alzheimer’s Disease in 1.9 million cells across 416 individuals
… of PD-L1 expression across all cell-types, cellular transport, and lipid dyshomeostasis. Overall, our study provides a novel method to analyze and compare the RNA velocity between AD and non-AD cohorts, and identifies a new set of differentiallyspliced AD genes, when previous analyses …
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Learning the language of biomolecular interactions
… unit of the cell, and their interactions drive cellular function. Interactions between proteins are responsible for a wide variety of functions raning from catalytic activity to cellular transport and signaling, and interactions between small molecules and proteins are the foundation of many …
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A proteomic and cytological characterisation of the buff-tailed bumblebee (Bombus terrestris) fat body and haemolymph -An immune perspective
… a detailed investigation of the molecular and cellular aspects of bumblebee health. The principal components of the B. terrestris immune system, the fat body (FB) and haemolymph were characterised here using proteomic and cytological methodologies. The FB proteome is highly enriched in …
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Consequences of Asymmetric Environment on the Mechanics of Lipid Bilayer
… are selective barriers that encapsulate cellular components and define the identity of organelles. A fundamental feature of membranes is an asymmetric distribution of lipids and proteins across them. While a basic level of asymmetry is maintained at all times, local and transient increase …
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Formation of morphogen gradients
… concentration of such morphogens. Morphogen transport through the tissue has been studied in experiments which lead to the suggestion of several transport mechanisms. While diffusion in the extracellular space contributes to transport, recent experiments on the morphogen Decapentaplegic (Dpp) …
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Finding functional groups of genes using pairwise relational data : methods and applications
… complexes and molecular pathways to achieve a cellular function such as DNA repair and cellular transport. A current emphasis in genomics research is to identify gene modules from gene profiles, which are measurements (such as a mutant phenotype or an expression level), associated with the …
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An Examination Of The Cytoplasmic Dynein Stepping Mechanism At The Single Molecule Level
… to examine the stepping mechanism of the cellular transport motor, cytoplasmic dynein. Cytoplasmic dynein walks along microtubules toward the minus end and is responsible for a wide range of cellular functions including cargo transport and chromosome alignment during cell division. This …
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Molecular Mechanism of Zipper Interacting Protein Kinase
… of ZIPK was used to determine the mechanism of cellular transport. This was done to address the difference in cellular localization between human and murine cells. The localization of human ZIPK is dictated by nuclear localization sequence 2 (NLS2) and the phosphorylation state of Thr299; the …
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Cytoskeletal changes in SY5Y neuroblastoma cells exposed to acrylamide: an immunocytochemical study
… as well as for maintenance of the normal intracellular environment. Without it, major functional deficits occur due to interference with cellular transport of membrane components, proteins and neurotransmitter substances and as a result, inadequate maintenance of the distal axon occurs. Through …
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Identification and characterization of novel autoregulatory mechanism controlling ataxia telangiectasis mutated gene expression, protein traffiking and function
… and in DDR also revealed a novel ATM sub-cellular trafficking mechanism which was dependent on its own kinase activity. This trafficking mechanism involved DNA damage induced Golgi to nuclear transport of phosphorylated ATM S-1981 to elicit DDR. This was found to be a conserved pathway …
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Modelling of colloidal dynamics in complex soft matter systems
… of Brownian diffusion and active directed cellular transport in the growth of the amyloid aggresome inside cells, thus unveiling the dominant role of diffusion over active transport.
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Understanding the ATP hydrolysis mechanism in myosin using computer simulation techniques
… contraction and a large number of additional cellular transport phenomena in all living organisms. While hydrolyzing ATP, myosin translocates along an actin filament. The catalytic cycle for ATP hydrolysis and the mechanical motor cycle are closely coupled. Although a large number of studies …
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Chemical Biology of Dynein
… with various Activities) motor protein that transports cellular cargoes towards the microtubule minus-end. Despite its essential role in intracellular transport, dynein remains the least understood cytoskeletal motor. With speeds >25 μm/min in cells, dynein's cellular functions are …
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Investigating the neuroprotective role of carboxyl-terminus of Hsc70-interacting protein (CHIP) in healthy aging
… in age-related demographic characteristics, the cellular and physiological mechanisms underlying aging itself remain ill-defined. Their intrinsic complexity is further exacerbated by the difficulty inherent in segregating processes associated with pathological aging from those related to the …
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