Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"cellular therapies"”.
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The Immunogenicity of Cholangiocyte Cellular Therapies
… however, so development of cholangiocyte cellular therapies capable of replacing or repairing damaged bile ducts would have significant therapeutic value. The safety of such therapies must be assessed before they are suitable for clinical translation and an essential component of that is …
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Overcoming Challenges in Cellular Therapies: A Systems Engineering Approach for Equitable Access
Cellular and gene therapies have ushered in a new era of medical treatment, promising cures previously thought unattainable. Technologies like CRISPR/Cas9 enable precise genome manipulation, yet challenges persist in therapy delivery, prompting the rise of ex vivo approaches. Despite the promise of …
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PEDOT:PSS Enhanced Electroporation for Cell Therapy Manufacturing
Cellular immunotherapies, such as chimeric antigen receptor (CAR) T cell therapies and macrophage therapies, have shown promising results in treating a wide range of cancers. Advances in these therapies focus on increasingly complex cellular systems to simultaneously optimize immune cell …
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Induced-Pluripotent Stem-Derived Neuronal Progenitor Cells As A Novel Treatment For Neurodegenerative Diseases
<p>Cellular therapies, as neuronal progenitor (NP) cells grafting, are promising therapies for patients affected with neurodegenerative diseases like Creutzfeldt-Jakob Disease (CJD). At this time there is no effective treatment or cure for CJD. The disease is inevitably fatal and affected people …
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The Impact of IL-9 on Disease in Murine Models of Systemic Lupus Erythematosus
… disease, and this finding could be harnessed for cellular therapies of disease.
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DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases
… strains for agriculture, or advancing human cellular therapies to treat diseases. Genomic alterations are most efficient when a double-strand DNA break is introduced at the loci where the modification is desired. Different classes of naturally occurring DNA endonucleases, including homing …
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The Rational Design and Use of Novel Small-Molecule Ice Recrystallization Inhibitors for the Cryopreservation of Hematopoietic Stem Cells and Red Blood Cells
… has been an increase in the development of new cellular therapies used for the treatment of various conditions. Thus, the rapid development of therapies requiring transfusion and transplantation of cells has resulted in a need to preserve these cellular therapy products. Cryopreservation is the …
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Microscale Tissue Engineering and Contributors of the Cellular Niche
… by their microenvironment or ‘niche’. While cellular therapies offer promising curative solutions for many diseases, the efficacy of transplanted cells is often hampered by a suboptimal microenvironment. One strategy to overcome this limitation is to reconstruct the niche of the cells of …
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Lung Progenitor Cell Transplantation for Pulmonary Fibrosis and Ex Vivo Expansion of Patch-Forming EpCAM⁺CD31⁺ Cells
… foundation for developing safe and reproducible cellular therapies for patients with pulmonary fibrosis.</p>
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Directly induced Neural Stem Cells transplantation and prospects for stem cell-based therapy
… I have focused my attention on investigating how cellular therapies could be used to (i) prevent neuronal damage, (ii) modulate the chronic activation of the immune system and (iii) replace the damaged myelin in PMS. Olfactory Ensheathing Cells (OECs) are a special population of glial cells known …
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Advancing T Cell–Based Immunotherapies: Identification of Tumor-Specific T Cell Receptor Targets and Mechanisms of Resistance in Solid Tumors
<p>Cancer immunotherapies, such as adoptive cell therapy, have transformed cancer treatment by eliciting durable immune responses. While adoptive cell therapy has demonstrated remarkable success in hematologic malignancies and several solid tumors, most patients with solid tumors either fail to …
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Mesenchymal stem cells as trophic mediators of neural differentiation
… as exciting candidates for potential use in cellular therapies and tissue engineering strategies. MSCs are defined at the functional level in terms of their ability to differentiate into mesodermal derivatives such as bone and fat. However, this functional definition is evolving, and there is …
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Identification of Novel Drivers of Haematopoietic Stem Cell Fate Using Low Cell Number Proteomics and Single Cell Profiling
The abrogation and de-regulation of cellular decisions in adult haematopoietic stem cells (HSCs) have been widely recognised as key contributing factors in ageing and disease. In particular, acquired mutations altering HSC self-renewal contribute to the formation of pre-leukaemic disorders, such as …
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A Novel, Codon-Based Approach to Preserve On-Tumor Activity and Reduce Off-Tumor Toxicity of Chimeric Antigen Receptor (CAR) T Cells
… phenomenon has yet to be described in adoptive cellular therapies to our knowledge. We hypothesized that rare codon engineering in Hu8F4-CAR can fine-tune its expression and/or function to reduce the likelihood of off-tumor activity.</p> <p> Here we demonstrate that rare codon engineering within …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… studies focus on the development of both acellular and cell-based therapies to allow neuroprotection, improve cell survival, and modulate the pro-inflammatory microenvironment. However, they proved very poor functional improvement in clinical trials. Given the complexity of the lesion …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
… a risk of developing liver disease and hepatocellular carcinoma (HCC). Treatment of HBV is met with several problems including poor tolerance and antiviral resistance and therefore, novel well-tolerated and effective therapies are required. Innate lymphocytes include NK, NT, NKT and T cells …
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Development of a canine model to evaluate CAR-T cell subsets
… disease. CAR constructs are made up of an extracellular antigen binding domain fused with one or more intracellular signaling domains. The extracellular domain is frequently built from the fused heavy and light chains of an antibody, called a single chain fragmented variable (scFv) domain, and …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… poorly to immune checkpoint inhibitors and cellular therapies. Rather than acting solely on tumors, metabolic dysfunction dismantles antitumor immunity both locally and distally. Distally, chronic systemic inflammation and stromal remodeling distort the architectural integrity of secondary …
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Characterizing T Cell Features of Atypical Lymphocytes for the Optimization of Adoptive Immunotherapies
… additional studies are needed to identify cellular characteristics associated with optimal treatment success. For Tregs, the role of T cell receptor (TCR) specificity against disease-associated antigens is not clear due, in part, to a lack of comparative studies of TCR repertoires across …
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Materials and Nanostructured Coatings for Soft Tissue Regeneration
… treatment or organ transplantation although cellular therapies based on progenitor cell injection are still problematic. Myocardial Tissue Engineering (MTE) is a Regenerative Medicine approach, able to integrate cell therapy with the use of polymeric substrates (myocardial scaffolds or heart …