Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"cellular stress response"”.
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MicroRNA Function in Cellular Stress Response
… to play critical roles in the regulation of cellular functions. There is an emerging concept that microRNAs may be just as essential for fine-tuning physiological functions and responding to changing environments and stress conditions as for viability or development. In this dissertation, two …
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Structural and Functional Evolution of Human Heat Shock Transcription Factors
<p>Proteotoxic stress is implicated in numerous human diseases including neurodegeneration, cancer, and diabetes. Unfortunately, our mechanistic understanding of the cellular response to proteotoxic stress is limited. A critical feature of the cellular stress response is the activation of Heat …
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The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome
… multiple behavioral tests and analyzed the cellular stress response through assessment of heat shock protein (Hsps) gene expression. We hypothesized that following mTBI, Kir6.2-knockout mice would have increased behavioral deficits, and aberrant Hsp expression. Results from behavioral and …
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USING ANTISENSE MESSENGER RNA TO DOWNREGULATE LON MEDIATED PROTEOLYSIS IN ESCHERICHIA COLI
… the desired recombinant protein elicits a cellular stress response that can result in reduced yields and degradation of the desired protein. In, lon is one of the major proteases responsible for this abnormal protein degradation, including recombinant proteins. Consequently, a variety of …
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Protein structure and interaction under environmental stress : from quality control recognition to evolution of collective behavior
… its structure, which in turn depends on the intracellular environment. Stress like heat shock or nutrient starvation can alter intracellular conditions, leading to protein misfolding - i.e. the inability of a protein to reach or maintain its native conformation. Since many proteins interact with …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… to normal skin. Exposure of cSCC cells to stress stimuli including ultraviolet irradiation, serum starvation, reactive oxygen species, or 5-fluorouracil increased hFWE expression, suggesting hFWE may be involved in the cellular stress response. Taken together, these results document a …
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
The cellular stress response represents an essential mechanism that enables cells to adapt to an array of environmental and physiological conditions. Given the importance of these adaptive responses, it comes as no surprise that dysregulation of the stress response has been strongly implicated in …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… to redox changes via modulation of intracellular glutathione. In response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions - 47 to - 44 in the hOgg1 promoter are necessary for …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
… to redox changes via modulation of intracellular glutathione. In response to changes in glutathione, changes in hOgg1 transcription occur similar to genes regulated by the transcription factor Nrf2. It was determined that positions - 47 to - 44 in the hOgg1 promoter are necessary for …
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A systems biology approach unravels the biological function of two tRNA wobble base modifications in fine-tuning translation and the response to environmental stress
… connect these tRNA modifications with various cellular stress response pathways. Follow up analyses of yeast cells subjected to environmental stresses were conducted and led to the discovery that the biosynthesis of mcm<sup>5</sup>s<sup>2</sup>U<sub>34</sub> is dynamically regulated in response …
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The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
… (NCL or C23) is an abundant genotoxic stress-responsive RNA binding phosphoprotein. NCL constitutes 10% of total nucleolar protein that has functions in multiple biological processes, including ribosome biogenesis, DNA/RNA metabolism, cellular response to DNA damage, cell growth, …
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Ethanol exposure during synaptogenesis in a mouse model of fetal alcohol spectrum disorders: acute and long-term effects on gene expression and behaviour
… Up-regulated transcripts were associated with cellular stress response, including both pro- and anti-apoptotic molecules, as well as maintenance of cell structural integrity. Down-regulated transcripts were associated with energetically costly processes such as ribosome biogenesis and cell …
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Investigating pathological mechanisms in the Thy1-hTDP43 ALS mouse model
… to have a common link, causing the generation of cellular stress. The generation of cellular stress induces the activation of many protective mechanisms, such as the formation of stress granules (SGs). SGs are typically transient structures that sequester translationally-stalled mRNA, RNA-binding …
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Ruolo della TDP-43 nella formazione dei granuli da stress nella Sclerosi Laterale Amiotrofica
… Recent studies suggest that TDP-43 may regulates stress granules dynamics that are cytoplasmic structures composed of non-translating messenger ribonucleoproteins (mRNPs) that rapidly aggregate in cells exposed to adverse environmental conditions. Stress granules function in part to triage RNA and …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
Cellular protein homeostasis is achieved by a delicate network of molecular chaperones and various proteolytic processes such as ubiquitin–proteasome system (UPS) to avoid a build-up of misfolded protein aggregates. The latter is a common denominator of neurodegeneration. Neurons are found to be …
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Stress and Growth Related Keratinocyte Pathways
Cellular stress and damage response mechanisms play a crucial role in physiological defense against hyperproliferative diseases, genotoxic injury, mutations and malignancy. An important first step in the cellular stress response is upregulation of immediate early genes that initiate and coordinate …
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RNA modifications and processing in cell homeostasis and in response to oxidative stress
… cell survival under normal conditions and in response to oxidative stress, and (2) to investigate the importance of Srsf2 in stem cells using skin as a model system. In the context of RNA modifications, firstly I described how NSun2-expressing cells enrich for transcripts related to enhanced …
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Insights into transcriptional regulation from natural and induced variation in closely related species
… for liver-specific biological processes, cellular stress response and abnormal liver phenotype, and they are associated with dysregulated genes with hepatocyte-specific functions. Finally, these findings also highlight the necessity of studying the activity of TFs bound both in a singleton …
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Circadian Regulation of Protein Homeostasis
… role both feeding into and being regulated by cellular timekeeping. I provide data in support of this in the first results chapter, showing that proteasome activity is essential for temporal organisation of circadian transcriptional networks, and that cellular proteasome activity is …
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