Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 180 for “"cellular stress"”.
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Protein synthesis in cellular stress
Mnoho organizmů z různých větví života se často potýká s buněčným stresem zapříčiněným podmíkami vnějšího prostředí. Pro boj s těmito nepříznivými podmínkami se vyvinulo mnoho komplexních mechanismů. Kvasinka Saccharomyces cerevisiae je obzvláště dobře vybavená pro eliminaci negativních účinků …
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MicroRNA Function in Cellular Stress Response
… to play critical roles in the regulation of cellular functions. There is an emerging concept that microRNAs may be just as essential for fine-tuning physiological functions and responding to changing environments and stress conditions as for viability or development. In this dissertation, two …
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Characterization of cellular stress systems using biological mass spectrometry
In recent years mass spectrometry has become an invaluable tool to address an array of biological questions. The versatility of this experimental approach does not only allow assignment of protein identity and identification of sequence specific modifications, but with the help of particular …
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Improving cancer therapy strategies via cellular stress and immune modulation
Despite significant progress in molecularly targeted and immune-based therapies, metastatic and chemoresistant cancers continue to exhibit poor clinical outcomes. This dissertation investigates two distinct therapeutic strategies designed to overcome tumor resistance and improve therapeutic …
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Modeling The Unfolded Protein Response And Its Connection To Cellular Stress
… Reticulum (ER) plays a pivotal role in cellular functioning. Proteins undergo modifications in the ER. The cell monitors protein folding and has a quality control. The incorrectly folded proteins are tagged for degradation or sent back to the refolding cycle. Upon accumulation of …
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
The cellular stress response represents an essential mechanism that enables cells to adapt to an array of environmental and physiological conditions. Given the importance of these adaptive responses, it comes as no surprise that dysregulation of the stress response has been strongly implicated in …
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Use of artificial neural network techniques to model proteomics of cellular stress
… essential to make a viable product. Performing cellular stress experiments on an industrial scale would prove far too costly; instead an ultra-scale down model is used here to mimic the effects of a large scale industrial plant in a laboratory, for example to study the effect of hydrodynamic …
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Regulation of transcription factors NRF2 and HSF1 in mediating cellular stress responses
The KEAP1/NRF2/ARE pathway is at the forefront of cellular defense. Induction of this pathway is protective against various conditions of stress such as oxidative stress and exposure to electrophiles. Conversely, failure to upregulate the pathway leads to increased disease susceptibility and …
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Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
… in Ca2+ leak, mitochondrial disorganization, and cellular stress. Although RyR1 expression is limited in the brain, the cerebellum may be particularly vulnerable to this disease because RyR1 is highly expressed in Purkinje neurons. In this study, Y522S-RyR1 in Purkinje cells exhibits a lower …
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Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
The epitranscriptome -- the naturally occurring system of chemical modifications on ribonucleic acid (RNA) --
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ROLE OF CELLULAR STRESS RESPONSES IN THE PATHOPHYSIOLOGY AND TREATMENT OF PSYCHIATRIC DISORDERS
… the most serious conditions classified among the stress-related psychiatric disorders. Not only it is one of the leading causes of disability worldwide but is also associated with poor treatment response and high rate of relapse, which dramatically increase the risk of death of affected …
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Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast
… a poorly perfused placenta hampered by hypoxic stress. Two stress-mediate angiogenic responses include post-transcriptional regulation of mRNA stability, and regulation of PML sequestering protein. We investigate whether these mechanisms occur in hypoxic stressed trophoblast and preeclamptic …
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Cellular Stress and Effects on Mitochondrial DNA: An Assessment of Stress Reduction & Protective Effects
Introduction: Psychological stress results in energy demands and changes in the mitochondria that produce 90% of bodily energy as adenosine triphosphate (ATP). Cell-free mitochondrial DNA (cf-mtDNA) is released into the bloodstream under stress which was induced with the International Affective …
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Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress.
… isoforms have central roles in many essential cellular processes, including proliferation, apoptosis, differentiation, cytoskeletal changes, and migration. The PKC family can be subgrouped into classical, novel and atypical isoforms depending on structure and sensitivity to the activators …
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Effects that Omega 3 and Omega 6 Dietary Ratios have on Cellular Stress in C. elegans
… whether omega 3:6 fatty acid ratios influence cellular stress and autophagy processes in the genetic model system Caenorhabditis elegans, as these processes are strongly linked to fat metabolism and have been reported to affect many of the same disorders. Unlike humans, C. elegans are able to …
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The effects of hydration status on markers of oxidative and cellular stress during prolonged exercise in hyperthermic environments
… between hyperthermia, dehydration and oxidative stress have been thoroughly studied separately within the literature both in vitro and in vivo. However, no in vivo attempts have been made to manipulate the hydration status of individuals to investigate the resulting changes in oxidative and …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… to normal skin. Exposure of cSCC cells to stress stimuli including ultraviolet irradiation, serum starvation, reactive oxygen species, or 5-fluorouracil increased hFWE expression, suggesting hFWE may be involved in the cellular stress response. Taken together, these results document a …
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TEMPOL and Insulin Resistance: A study of the underlying mechanisms behind changes in glucose metabolism, lipid accumulation and cellular stress
… Overnutrition-induced obesity drives oxidative stress and inflammation, leading to insulin resistance. There are currently no successful treatments to treat insulin resistance or its downstream clinical sequelae. It was hypothesized that TEMPOL, a nitroxide, could suppress diet-induced insulin …
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Molecular and Cellular Mechanisms Responsible for Low-grade Stress and Inflammation Triggered By Super-low Dose Endotoxin
… mechanisms utilized by super-low dose LPS in cellular stress and low-grade inflammation. In the first study, the molecular mechanisms governing the role of super-low dose LPS on cellular stress and necroptosis were examined. We show that in the presence of super-low dose LPS (50pg/ml), the key …
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