Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"cellular signalling pathways"”.
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Cellular signalling pathways involved in muscle atrophy in cancer cachexia
… signal transduction. 15(S)-HETE acts as an intracellular mediator of PIF and exerts an effect through the activation of PKC and subsequently IKK, which phosphorylates IkBα and allows NF-kB to migrate to the nucleus. This effect was negated with the PKC inhibitor calphostin C (300nM). A …
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Cellular signalling pathways involved in thermoprotection of neural ciruit function in the locust.
… (OA/cAMP/PKA) and nitrergic (NO/cGMP/PKG) signalling pathways and tested their involvement in conferring thermotolerance to the vCPG during heat stress. I found that long applications of octopamine, or increased adenylate cyclase activity generated vCPG thermotolerance and was dependent …
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two discrete states. During lytic infection, …
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SUFU in SHH signalling mediated myogenesis
… development and involves a multitude of cellular signalling pathways. Among these include the Sonic hedgehog (Shh) signalling pathway which must be deactivated for differentiation into muscle cells to occur. However, less is known regarding the pathways operation during cell …
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A tool for automated inference in rule-based biological models
… help researchers investigate systems such as cellular signalling pathways. Although these models are generally programmed by hand, some research efforts aim to program them automatically using biological facts extracted from papers via natural language processing. However, NLP facts cannot …
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Multiscale Modelling and Analysis of Plant Cell Signalling Processes and Biomechanics
… are regulated by complex networks of interacting signalling molecules. Signalling pathways activate in response to external or internal cues, leading to a series of signalling processes which end with changes in gene expression. By modifying protein level in this way, specific signalling molecules …
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Investigation and control of dermal fibroblast signaling during injury repair
… health risk. Therefore, understanding the cellular processes regulating wound healing and correcting them when they go awry is essential for meeting these population’s healthcare needs. Wound healing is a complex process consisting of a suite of injury repair programs executed by cells in …
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TRANSCRIPTIONAL NETWORKS VARIATIONS DURING CELL CYCLE PROGRESSION IN HUMAN EMBRYONIC STEM CELLS
… the transcriptional activity of Activin/Nodal signalling during progression of the cell cycle in human Embryonic Stem Cells (hESCs). As a consequence, hESCs can only differentiate into endoderm in the Early G1 phase when Cyclin Ds are expressed at low levels. These results show the mechanisms …
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Investigating and exploiting the latency-associated expression of the human cytomegalovirus gene US28 in early myeloid lineage cells.
… US28 expression was found to attenuate cellular signalling pathways in latently infected cells; in particular, MAP kinase and NFκB. Interestingly, deletion of the US28 gene or inhibition of the US28 protein resulted in the expression of lytic antigens which allowed detection of infected …
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Understanding the mechanisms of phosphatidylserine exposure in sickle cells
… investigates the possible physiological and cellular signalling pathways involved in PS exposure in RBCs from SCD patients. In the first part, conditions specific to the renal medulla were examined as the majority of SCD patients suffer from nephropathy early in life. It is hypothesised that …
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Molekulare Mechanismen der Regulation von Matrixkontakten und Migration melanozytärer Zellen durch das Protein MIA
… partners, its influence on regulation of cellular signaling pathways and on the MIA-expression regulatory pathways. All melanoma cell lines show a strong expression of MIA protein. MIA interacts with proteins of the extracellular matrix (ECM), specifically with fibronectin and laminin. …
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The mechanism of tamoxifen action on glioma cell lines
… thus, inhibiting gene transcription and cellular proliferation. In vitro studies have shown that Tamoxifen can inhibit the growth of a brain tumour cell lines, but whether the mechanism involves oestrogen blockade remains a matter of some debate. As well as its effect in blocking estrogen …
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The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells
The extracellular-regulated kinase (ERK) signalling pathway is involved in the control of different biological processes such as survival, proliferation and differentiation. In PC12 cells, the ERK signalling pathway integrates different external stimuli: epidermal growth factor (EGF) stimulates the …
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Mechanism underlying linkage-selective polyubiquitin recognition
… types can couple modified proteins to diverse cellular signalling pathways. For example, proteins modified with K48 polyUb chains are targeted for proteasomal degradation. In contrast, modification with K63 polyUb chains has non-proteolytic roles in DNA damage response and immune signalling …
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IDENTIFICATION OF COMMON MECHANISMS TO INTRACELLULARLY ACCOMMODATE BENEFICIAL OR PATHOGENIC FUNGI IN RICE
… potential common genetic mechanisms for the intracellular accommodation of these fungi in rice roots. The functional roles of genes commonly induced during both R. irregularis and M. oryzae root colonization were examined to determine if they are part of a shared plant genetic mechanism that …
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Role of the lactoferrin-binding protein in pathogenesis of streptococcus uberis
… adhesion to host epithelial cells and intracellular invasion by the bacteria. Alternatively, high-affinity binding of the abundant iron-chelating component of the host milk (lactoferrin) suggests that Lbp of S. uberis might play role in iron acquisition by the bacterium. Finally, Lbp might …
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Localisation of sex steroid receptors and effect of Tamoxifen upon glioma cell lines in vitro
… thus, inhibiting gene transcription and cellular proliferation. In vitro studies have shown that Tamoxifen can inhibit the growth of a brain tumour cell lines, but whether the mechanism involves oestrogen blockade remains a matter of some debate. As well as its effect in blocking estrogen …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
… ALK proteins are involved in diverse cellular signalling pathways such as Ras/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3-kinase (PI3K)/Akt, and Janus protein tyrosine kinase (JAK)/signal transducer and activator of transcription (STAT). Furthermore, ALK is …