Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"cellular signalling"”.
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Evolutionary, structural and functional features of cellular signalling networks
… diversify the proteome in response to intracellular and extracellular signals. Since thousands of modified residues as well as entirely new modification types have recently been discovered in proteins, elucidating their biological functions and identifying the protein components of these PTM …
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Cellular signalling pathways involved in muscle atrophy in cancer cachexia
… signal transduction. 15(S)-HETE acts as an intracellular mediator of PIF and exerts an effect through the activation of PKC and subsequently IKK, which phosphorylates IkBα and allows NF-kB to migrate to the nucleus. This effect was negated with the PKC inhibitor calphostin C (300nM). A …
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Cellular signalling pathways involved in thermoprotection of neural ciruit function in the locust.
… (OA/cAMP/PKA) and nitrergic (NO/cGMP/PKG) signalling pathways and tested their involvement in conferring thermotolerance to the vCPG during heat stress. I found that long applications of octopamine, or increased adenylate cyclase activity generated vCPG thermotolerance and was dependent …
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
As obligate intracellular parasites, viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two discrete states. During lytic infection, …
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The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives
… flux of cations in tumour cells and subsequent cellular responses are shown to rely on this mechanism for their initiation. Ion fluxes activated p38 MAPK signalling, which was found to be crucially involved in tumour cell death. Paper III identifies oleate as the functional ligand in HAMLET …
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Multiscale Modelling and Analysis of Plant Cell Signalling Processes and Biomechanics
… are regulated by complex networks of interacting signalling molecules. Signalling pathways activate in response to external or internal cues, leading to a series of signalling processes which end with changes in gene expression. By modifying protein level in this way, specific signalling molecules …
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Network approaches for data-driven reconstruction of intracellular signalling
Intra-cellular signalling determines how cells process information. Through the integration of diverse chemical and physical stimuli, cells can enact transcription, among other changes to modulate growth, fate and survival. It is through the dysregulation of such processes that many diseases, …
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Intercellular Feedback in Hematopoiesis
Despite the importance of inter-cellular (between cell) communication networks in regulating homeostasis in multicellular organisms, very little is known about their topology, dynamics, or functional significance. Inter-cellular communication networks are particularly relevant in stem cell biology, …
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SUFU in SHH signalling mediated myogenesis
… development and involves a multitude of cellular signalling pathways. Among these include the Sonic hedgehog (Shh) signalling pathway which must be deactivated for differentiation into muscle cells to occur. However, less is known regarding the pathways operation during cell …
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A tool for automated inference in rule-based biological models
… help researchers investigate systems such as cellular signalling pathways. Although these models are generally programmed by hand, some research efforts aim to program them automatically using biological facts extracted from papers via natural language processing. However, NLP facts cannot …
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Kinetics of cell attachment and spreading on hard and soft substrates
… and biochemical and physical cues can activate cellular signalling, which leads to changes in cell behaviour such as proliferation and shape. Understanding cells' interactions with their environment is also important for understanding diseases. For example mechanosensing, which is the sensing of …
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Hypergravitational stimulation of cell differentiation
… field within biophysics which encapsulates cellular responses to mechanical stimuli. Mechanotransduction is the highly dynamic and varied downstream cellular signalling which is activated through many different modes of mechanical stimulation. Control of stem cell differentiation has been …
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Interrogating the molecular mechanism of signal transduction in the TGF-β receptor superfamily
A major unanswered question in cellular signalling is how binding of an extracellular ligand to its cell-surface receptor triggers activation of an intracellular signalling cascade to achieve a physiological response. TGF-β signalling is central to many physiological processes, from embryonic …
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Regulation of Cholesterol Biosynthesis in Hepatocytes
… HMG-CoA reductase activity and decreased cellular accumulation of cholesterol. Berberine was shown to regulate HMG-CoA reductase through activation of metabolic regulator AMP-activated protein kinase, which modifies HMG-CoA reductase post-translationally and thereby decreases its activity. …
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REGULATED UPTAKE OF BIOPOLYMERS Role of cell surface proteoglycans Implications for drug and gene delivery
… over the plasma membrane. Internalization, i.e. cellular import of extracellular material, is a fundamental process, which provides cells with nutrients and enables the immune cells of higher organisms to remove debris, sample their surroundings for antigens and to fight microbes. Moreover, …
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A novel 4-valued discrete network for the analysis of signalling events integrating protein interaction and gene expression data applied on hematopoietic diefferentiation
… is crucial for the interplay of cells in multicellular organisms and controls among other things cellular proliferation and cellular differentiation. The complexity of signalling networks and the absence of comprehensive and accurate quantitative data make a precise mathematical description of …
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Identification and characterisation of novel marker proteins involved in X-linked muscular dystrophy
… secondary alterations in metabolic pathways, cellular signalling and ion homeostasis regulation cause fibre degeneration leading to severe muscle weakness. Skeletal muscle deteriorates to the extent that sufferers are wheelchair bound by early adulthood and severe diaphragm degeneration can …
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Integration of signalling in smooth muscle caveolae
… that are considered to play a role in cellular signalling. Caveolins and cavins as well as cholesterol are required for the structure and function of caveolae. The papers summarized in this thesis examine the role of caveolae in smooth muscle function. Ca2+-sensitization is a …
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Proteomic Profiling of the mdx Animal Model for Duchenne Muscular Dystrophy
… glycoprotein complex, secondary alterations in cellular signalling, ion homeostasis regulation and metabolic pathways lead to fiber degeneration and subsequent fibrosis. These changes result in loss of ambulation and sufferers being wheelchair bound in early adulthood. Severe diaphragm and …
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Investigation and control of dermal fibroblast signaling during injury repair
… health risk. Therefore, understanding the cellular processes regulating wound healing and correcting them when they go awry is essential for meeting these population’s healthcare needs. Wound healing is a complex process consisting of a suite of injury repair programs executed by cells in …
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