Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"cellular signal"”.
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Disruption of mitochondrial redox homeostasis as a cellular signal.
… components of eukaryotic cells and exchange signalling molecules, metabolites, proteins and lipids with the rest of the cell. The organelle is key for energy metabolism as they provide most of the cellular ATP through oxidative phosphorylation and regulate intermediate metabolism. …
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URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
… human breast cancer cells via regulating cellular signal transduction pathways. Specific objectives are designed as: a) to investigate anti-proliferation and anti-invasion effects of UA in MDA-MB-231 human breast cancer cells; b) To determine specific molecular targets of UA on cellular …
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Constant Conduction Angle Biasing for Class C Monolithic RF Power Amplifiers
… – the situation where a nearby user’s strong cellular signal masks the cellular signal of a faraway user – base stations continually enforce power control. That is, nearby users must lower their transmit power. In CDMA technology, power control can be as large as 70-80dB. At low power outputs, …
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NEW METHODS FOR DETECTING BIOMARKERS OF OXIDATIVE STRESS AND REDOX SIGNALING ON PROTEIN CYSTEINE RESIDUES
… or oxygen species), participate in a variety of cellular redox processes and have become well recognized as messengers in cellular signal transduction. One important mechanism by which cellular redox-based signaling occurs is reversible oxidation of cysteine residues in the presence of low …
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The dynamics of enzymatic switch cascades
… a highly conserved architecture utilised in cellular signal transduction. In treating the equations of motion, we replace the usual deterministic differential equation formalism with stochastic equations to accurately model the 'effective collisions' picture of the biochemical reactions that …
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Probabilistic models for mobile phone trajectory estimation
… alternatives to GPS such as WiFi localization, cellular localization, and inertial sensing (with the accelerometer and gyroscope) that consume less energy and work indoors. The key challenge is to match a sequence of infrequent (from sub-sampling) and inaccurate (from WiFi, cellular or inertial …
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Investigations into the chemistry of protein tyrosine phosphatase redox regulation
Transmission of complex intracellular signals, such as those for glucose uptake or proliferation, is often accomplished through the reversible phosphorylation of specific protein tyrosine residues. This reversible phosphorylation serves as a biochemical "rheostat" that alters a protein's functional …
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A Multi-Carrier Collaborative Solution to Minimize Connectivity-Loss
… messaging applications, etc. Unfortunately, the cellular networks on our smartphones are not perfect and do not always have cellular signal. Our devices often lose Internet connection when users are on the go and traveling.</p> <p>This thesis presents a novel in-depth implementation and …
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Does IT lead to more equal treatment? : empirical study of the effect of smartphone use on customer complaint resolution
… granular geographic data on two proxies for cellular signal strength. This analysis again suggests that mobile applications can partially eliminate the disparity between educated and uneducated people in terms of how long it takes to get their complaints resolved. We present suggestive …
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Characterization of Gf a Drosophila trimeric G protein alpha subunit
… and interpretation of the multitude of extracellular stimuli to which they are exposed. Plasma membrane receptors play a key role in the transmission of such signals. G-protein coupled receptors (GPCRs) are the largest class of cell surface receptors that respond to an enormous diversity of …
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Computational modeling of the IL-4 pathway to understand principles of systemic redox regulation in cell signaling
… that ROS such as hydrogen peroxide can act as signaling molecules and are required for physiological functioning of a number of signaling pathways. Therefore, a mechanistic basis of ROS-mediated regulation of cell signaling must be established to enable rational design of antioxidant-based …
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Chemically Based Interrogation of Smoothened, a Proto-Oncogenic Component of the Hedgehog Signal Transduction Pathway
Aberrant activation of the Hedgehog (Hh) signal transduction pathway is crucial for the initiation and maintenance of many cancer types. Underlying this deviant signaling process in most cases of cancer is genetic mutations that give rise to misactivation of the seven transmembrane oncoprotein, …
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Signal processing in biological cells : proteins, networks, and models
… to understand the algorithms implemented by the signaling pathways that perform the processing. An example of how to emulate one of these algorithms in other signal processing contexts is also presented. At a high modeling level, the focus is on the network topology rather than the dynamical …
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Design principles of mammalian signaling networks : emergent properties at modular and global scales
… chemistry to investigate several aspects of cellular signal transduction at both the modular and global levels. Design principles of biological networks and cell signaling processes pertinent to disease progression emerge from these studies. It is my hope that knowledge of these principles …
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In silico systems analysis of biopathways
… pathway alignment; recommends a nomenclature of cellular signal transduction; and attempts to standardize the representation of biological pathways. Hybrid Petri net methodology is exploited to model metabolic networks. Kinetic modeling strategy and Petri net modeling algorithm are applied to …
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Computational analysis of cell-cell communication in the tumor microenvironment
… approach to include inferences of single-cell signaling pathway and transcription factor activity. We then identified protein-protein interaction networks that connect extra-cellular receptor-ligand interactions to intra-cellular signal transduction pathways. Using this approach, we compared …
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PhoQ: Structural and Mechanistic Investigations into an Important Bacterial Sensor Kinase
… systems represent the dominant mechanism for cellular signal transduction in prokaryotes. One particular system, PhoQ, has been the focus of our interest because it is the switch that controls virulence in Salmonella and other pathogenic gram negative bacteria. Certain domains of PhoQ and …
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The cloning and characterization of the TIK kinase.
… which plays a central role in a wide variety of cellular functions. The ready reversibility of the phosphotransfer reaction makes it well-suited for rapid cellular responses, such as the responses to signals from extracellular stimuli. Members of the protein kinase family have been identified as …
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Computational Ligand-Based CNS Therapeutic Design: The Search for Novel-Scaffold Norepinephrine Transporter Inhibitors
… (MAT) proteins are responsible for regulating cellular signal transduction through control of neurotransmitter reuptake in the synapse, and are therefore relevant to diseases including addiction, psychosis, anxiety and depression. MATs, specifically the serotonin transporter (SERT or 5-HTT), …
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Physiological and cellular characterization of a plant natriuretic peptide
… capacity to survive. Plants can use multiple signaling pathways and signals to mediate their response; for example, at least four different signal pathways have been identified for water-deficit stress (Shinozaki and Yamaguchi-Shinozaki, 1997; Xiong et al., 2002). Different forms of stress may …
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