Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 96 for “"cellular senescence"”.
-
Nucleolar dynamics in cellular senescence
… dynamic of nucleolar area triggered by different senescence inducers remains elusive. Besides, gene expression associated with enlarged nucleoli is not well understood. Here, I show nucleolar dynamics in different types of cellular senescence including oncogene-induced senescence (OIS), secondary …
-
The role of Biophotons in cellular senescence.
Senescence is the irreversible arrest of cell proliferation. While serving as a natural barrier against mutation progression, senescence's metabolic activity and elevated ROS levels can pose significant health risks. Concurrently, cellular metabolic processes, including mitochondrial respiration, …
-
Functional Identification of MicroRNAs Counteracting Cellular Senescence
Cellular senescence is a process closely linked to organismal ageing, and clearance of senescent cells has been shown to revert aspects of the ageing phenotype. We sought to identify miRNAs able to counteract replicative senescence at the cellular level, and investigate their effect in vivo. A …
-
P16/INK4a controls the morphology program associated with cellular senescence
Background: Cellular senescence is a state which normal cells enter following an extensive period of proliferation or upon exposure to various kinds of stress. The senescence program involves G1 arrest accompanied by dramatic changes in cell function and morphology. The molecular mechanisms that …
-
Autonomous and non-autonomous regulation of chromatin structure during cellular senescence
… paracrine signalling mediated by factors of the senescence-associated secretory phenotype (SASP), we have recently identified that NOTCH1 can drive a unique form of senescence in adjacent cells via juxtacrine signalling. Here, we show that NOTCH1 signalling confers a dramatic impact on chromatin …
-
Quantitative proteomic analysis of cellular senescence: from systems biology to targeted signaling pathways
Cellular senescence, an irreversible cell cycle arrest induced by a diversity of stimuli, has been considered as an innate tumor suppressing mechanism with implications and applications in cancer therapy. The senescence phenomenon was first associated with aging as Hayflick and colleagues observed …
-
Cellular Senescence in Non-Small Cell Lung Cancer: from mechanisms to therapeutic opportunities
… are crucial to improve lung cancer survival. Cellular senescence is a powerful tumour-suppressive mechanism whereby cells stably enter a cell-cycle arrest in response to oncogenic stress. However, the accumulation of senescent cells can alter the tumour microenvironment through a strong …
-
The role of High Mobility Group A1 protein in transcriptional regulation of cellular senescence
Cellular senescence is characterised by the irreversible arrest of the cell cycle, triggered by diverse stress, such as oncogenic stress. The chromatin structure of senescent cells changes dramatically, exemplified by the formation of senescence-associated heterochromatic foci (SAHF). Moreover, …
-
A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Cellular Senescence
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Toward a Quantitative Analysis of PARP-1 and Poly(ADP-ribosyl)ation in Cellular Senescence
… systems involving the induction of replicative senescence in cultured cells have been indispensable in elucidating some of the mechanisms underlying this complex process. An understanding of how and why cellular senescence occurs is thus critical to the field of aging research. While there is …
-
Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
PURPOSE: Hepatocellular carcinoma (HCC) is a primary malignancy (cancer) of the liver. HCC has been known as androgen-dependent tumor with incidence of five times higher and worse prognosis in male than female. Steroid hormones and their receptors play a major role in the development of many types …
-
Regulatory Factors of Cellular Senescence in Human Diploid Fibroblast : SA-p-Erk1/2, PP1/2A, PKCα
… certain number of divisions, called replicative senescence, which is paragon of the general process of cellular senescence. Once senescent, cells continue to function metabolically, but will not respond to mitogens. Decreased growth rate, limited cell division, flat and large cell shapes, and …
-
Nuclear accumulation of G-actin in cellular senescence: Reduced expressions of exportin 6 and Ran small G protein
… was accumulated in nucleus during replicative senescence of human diploid fibroblast (HDF). In the present study, we found that the increase of doubling time of HDF cells decreased exp6 and Ran expression as well as phosphorylated cofilin. Concurrently, Ran was transported into the cytoplasm. …
-
Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
… capacity in vivo and in vitro, termed senescence and later, thought to contribute to molecular and cellular organismal aging. There are several studies that demonstrate the importance of the GH/IGF axis in longevity, aging and cellular senescence. One primary component of the IGF …
-
Role of protein kinase C isozymes in cellular senescence and reversal of senescence in response to 12-O-tetradecanoylphorbol-13 acetate (TPA) treatment in
Cellular senescence plays an important role in biological processes such as development, aging and tumorigenesis, and it is a process of permanent growth arrest when cells lose ability to reactivate cell division cycle. One of the common molecular features of senescent cells is the failure of …
-
A maternal high fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats
… antioxidant defense capacity and causes cellular senescence in liver of adult offspring rats, which might increase risk of developing chronic liver disease. Timed-pregnant Sprague Dawley rats were fed a HF diet (45% of energy from fat) or a control (C) diet (16% of energy from fat) during …
-
The role of accelerated ageing in aberrant lung tissue repair and remodelling in COPD
… age-matched smokers without COPD. Recently, extracellular matrix (ECM) dysregulation has been described as an additional ageing hallmark of the lungs. ECM dysregulation can cause aberrant lung tissue repair and remodelling. Lung fibroblasts and airway smooth muscle cells (ASMCs) are the major …
Page 1 of 5