Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"cellular prion protein"”.
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Interaction studies of the cellular prion protein
Prion diseases are rare but fatal neurodegenerative diseases which occur both in humans and mammals caused by the prion protein (PrP) which is well conserved among the species. In this thesis the biochemical properties and the function of prion protein were investiagted using different methods. The …
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Cellular Prion Protein (PrPC): Identification and Characterization of Novel Interacting Partners
The cellular prion protein (PrPC) is highly conserved throughout the evolution of mammals. (What does this sentence mean? What do you mean by ``conserved´´? This protein was higly conserved during the evolution of mammals [pantera et al. 2009; Jiayu et al.2009] and the gene tree deduced from the …
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Development and Application of a Novel Assay for Rapid Identification of Cellular Prion Protein Modulators
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are fatal neurodegenerative disorders caused by the misfolding and accumulation of proteins known as prions. Despite decades of research, no effective treatment is available, and the main therapeutic strategy being pursued is to …
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
… disease caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is associated with upregulation of various growth factor …
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Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein
Prions have been extensively studied since they represent a new class of infectious agents in which a protein, PrPSc (prion scrapie), appears to be the sole component of the infectious particle. They are responsible for transmissible spongiform encephalopathies (TSEs), which affect both, humans and …
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Exploring Novel Immunodiagnostics for Prion Disease
Prion Diseases, or Transmissible Spongiform Encephalopathies (TSEs), are rapidly progressive and fatal neurodegenerative diseases of mammals. TSEs of global importance include Creutzfeldt-Jakob Disease (CJD) in humans, Chronic Wasting Disease (CWD) in cervids, and Bovine Spongiform Encephalopathy …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of …
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ACUTE CELLULAR UPTAKE OF ABNORMAL PRION PROTEIN IS CELL TYPE AND SCRAPIE STRAIN INDEPENDENT
… an infected host largely remains unclear. At the cellular level, the uptake of protease resistant prion protein (PrP-res), which strongly correlates with infectivity and is a valid marker for TSE infection, is one of the earliest events that must occur during TSE infection. Given the difficulty of …
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Application of copper isotope abundance measurements to study copper trafficking in vivo
… copper, a critical enzyme cofactor, but a potent cellular toxin when unbound inside the cell. This thesis describes the development of an analytical technique to measure isotope amount ratios in biological systems. The technique was then implemented to determine how the distribution of copper …
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Structure determination of proteins and peptides in solution: simulation, chirality and NMR studies
The study of protein fold is a central problem in life science, leading in the last years to several attempts for improving our knowledge of the protein structures. In this thesis this challenging problem is tackled by means of molecular dynamics, chirality and NMR studies. In the last decades, …
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The subcellular trafficking of the prion protein: Characterisation of the function of the PrPc N-terminus
… conformational alteration of the non-pathogenic cellular prion protein (PrPc) into a infectious isoform denoted PrPSc. The latter therefore represents a pathogenic agent (prion) which does not contain nucleic acids. During biogenesis, PrPc undergoes posttranslational modifications with the …
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Lipid raft signaling in cofilin-actin rod formation induced by amyloid-β and TNFα
… Cofilin is an F-actin assembly regulatory protein critical to various actin-dependent processes, such as cytokinesis, cell migration, and neurite formation. Overexpression or hyperactivation (excessive dephosphorylation) of cofilin coupled with its oxidation can lead to formation of rods. …
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Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells
The host encoded cellular prion protein (PrPC) is an N-linked glycoprotein tethered to the cell membrane by a glycophosphatidylinositol (GPI) anchor. Under certain conditions, PrPC can undergo conversion into a conformationally-altered isoform (PrPSc) widely believed to be the pathogenic agent of …
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Investigation of Monoaminergic Neurotransmitter Systems as a Method to Study Alzheimer's Disease-Related Neurodegeneration
… [7]. Furthermore, defining a potential cellular or molecular mechanism for MAergic neurodegeneration remains unanswered. To better identify the factors leading to MAergic neurodegeneration in mouse models of Aβ pathology, we set out to address certain questions that were left open. …