Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"cellular plasticity"”.
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The Role of Metabolism and Epigenetics in Regulating Cellular Plasticity
… us to monitor cell metabolism, epigenetics, and plasticity, from the same sample.
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Cellular Plasticity And Heterogeneity: Implications In Tumor Cell Invasion And Metastasis
… natural evolution or through movement between cellular states collectively known as “cellular plasticity.” This heterogeneity and plasticity are critical drivers of phenotypic diversity culminating in many facets of disease progression, such as metastasis. While the existence of heterogeneity …
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FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY
Chromosomal instability and its cellular consequences represent critical aspects of cancer progression and genomic instability. The research presented in this thesis encompasses two complementary projects, focusing on distinct yet interconnected molecular pathways. The first project investigates …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… stimuli can dramatically alter the cellular composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
… regenerate without stem cells by induction of cellular plasticity between differentiated cells. Although essential for the remarkable capacity for pancreas regeneration, this property entails a vulnerability to cancer through acinar-to-ductal metaplasia and dedifferentiation by …
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Investigating intratumoural heterogeneity and plasticity with multiplexed single-cell assays
… but little is known about how CRC cells invoke cellular plasticity by shifting their cell states following treatment with KRAS inhibitors and drug combinations. To address questions about tumour plasticity in the context response towards KRAS inhibitors, I applied massively parallel and …
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… AT1 to AT2 cell fate conversion. This remarkable cellular plasticity was further exemplified by loss of Nkx2-1, whereupon both AT1 and AT2 cells first lose chromatin accessibility at their respective cell type-specific and lineage Nkx2-1 binding sites and gain chromatin accessibility at NKX2-1 …
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Behavioural and cellular basis of the vulnerability to develop compulsive heroin seeking habits
… the psychological, behavioural, neural and cellular mechanisms involved in the vulnerability to develop compulsive heroin seeking. Chapter 4 aimed to identify behavioural traits, such as anxiety, stress reactivity or decision making, that predict an increased vulnerability to develop …
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Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
The mechanisms that regulate the cellular behaviors including morphology, motility, navigation, and connectivity that are critical for normal human health are still incompletely understood. These types of behaviors are regulated through the ability of guidance cues that are present outside of cells …
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Caste-Specific Expression Of Coding And Noncoding Genes In Ant Brains
… The third section covers our investigation of cellular plasticity between brains of Harpegnathos ants of different castes and ages using single-cell sequencing, aided by the new genome assembly. Along with establishing a map of cell types in the social insect brain, we identified a …
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Understanding Developmental Decision Making in Malaria Parasites using Single-Cell Transcriptomics
… of the genus Plasmodium which display remarkable cellular plasticity during their complex life cycle with large variations in size (1.2 to 50 μm) and the environments they inhabit in mammalian and mosquito hosts. Clinical symptoms of malaria result from asexual replication within red blood cells, …
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Role of biomechanics and tumor microenvironment in osteosarcoma progression
… microenvironment and the interactions between cellular neighborhoods. Chapter 1 is an introduction and a detailed review of existing literature on the mechanobiological pathways relevant to osteosarcoma. It underscores the significance of tumor mechanobiology at both macro and cellular levels …
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Neural Plasticity in the Amygdala Across the Development of an Incentive Cocaine Seeking Habit
… taking and seeking, I aimed to elucidate the cellular plasticity mechanisms in the amygdala that underlie this functional shift. The General Introduction in Chapter 1 gives an overview of the literature informing the approach I took, the methodology of which is presented in Chapter 2, The …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… help understanding human brain development and cellular plasticity. The presence of a somatic NSC pool in the meninges of the adult human brain may provide a new source of adult NSCs which may be potentially used in regenerative medicine for brain repair in neurodegenerative diseases.