Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"cellular motility"”.
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The application of signaling networks to cancer metastasis and cellular motility through the EGFR pathway
… networks and molecular pathways involved in cellular signaling and linking intracellular signaling to the mechanical machinery of the cell, it is possible to quickly check in silico the effects of changing various feedback parameters and signaling molecule concentrations. By creating a model …
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Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels
… I hypothesise that therapies which target cellular motility pathways could effectively slow tumour dispersal and widen the time window for administration of frontline treatments aimed at direct eradication of primary tumours. The array of signal transduction pathways that control cellular …
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Fabrication of Organized Anisotropic Materials via Evaporative Self-Assembly
… of self-assembly in the context of extracellular matrix and cell culture. Chapter 2 describes the crystallization of gold nanotriangles (AuNTs) into hexagonal close-packed superlattices by slow evaporation and includes a morphological comparison of the crystallization habits of gold …
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Investigation of conserved Flagellum proteins in Trypanosoma brucei
… protein ablation has a detrimental effect on cellular motility. This work provides further understanding into the complexities of flagellum biogenesis in T. brucei and the downstream effects on cell motility and morphogenesis.
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Integrative simulation framework for modeling dynamic cellular phenomena in 3D over time
… excitable cells, circadian rhythm, cell cycle, cellular motility, membrane transporters, metabolic pathways, and signal transduction networks. In comparison to 2D methods, the use of a 3D geometry provides considerably more significant data. The possibility of simulating different compartments …
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Role of Syk in the regulation of cytoskeleton and stress granules in breast cancer
… in tumor progression, acting as an inhibitor of cellular motility and metastasis in highly invasive cancer cells. Multiharmonic atomic force microscopy (AFM) was used to map nanomechanical properties of live MDA-MB-231 breast cancer cells either lacking or expressing Syk. The expression of Syk …
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Structural Stiffness Gradient along a Single Nanofiber and Associated Single Cell Response
… microenvironment of cells directly affects cellular motility and cytoskeletal arrangement. Specifically, previous studies have explored the role of material stiffness (Young's modulus: N/m2) on cell behavior including attachment, spreading, migration, cytoskeleton arrangement (stress fiber …
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Lineage-Specific Phenotypic Abnormalities in iPSC-Derived Smooth Muscle Cells from Type-I Loeys-Dietz Syndrome
… TGF-β signalling, irregular expression of extracellular matrix, contractility defect, inability to regulate cell proliferation, poor cellular motility, and mitochondrial abnormality. In contrast, these defects were not detected in NC-SMC. Quantitative proteomics identified a significantly higher …
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Actin polymerization dynamics at the leading edge
Actin-based cell motility plays crucial role throughout the lifetime of an organism. While the dendritic nucleation model explains the initiation and organization of the actin network in lamellipodia, two questions need to be answered. In this study, I reconstructed cellular motility in vitro to …
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Characterization and Functional Analysis of a Newly Identified Human MT5-MMP Transcript Variant Isolated from Multipotent NT2 Cells
… in the adult. MT5-MMP is a mediator of pericellular proteolysis and is thought to have a functional impact on neurite outgrowth. The studies presented in this work were designed to examine MT5-MMP expression in cultured NT2 cells, a model of newogenesis and neuronal differentiation, and in …
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Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis
… that ormeloxifene significantly decreased the cellular proliferation and clonogenic potential of cervical cancer cells. Ormeloxifene also reduced the cellular motility and induced the apoptosis via targeting PI3K-Akt signaling in these cells. Furthermore, ormeloxifene modulated the HPV induced …
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The Regulation of Cellular Localization of Both Active and Inactive ERK1/2
… regulation and activity attributed to the extracellular signal regulated kinase1/2 (ERK1/2) cascade is how the cellular response to different ligands, cellular environment, and other cellular signals is generated. Part of the answer to the question is the ligand and context-specific spatial …
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The role of hCLCA2 and hCLCA4 in suppression of breast cancer progression
… acquire spindle cell morphology and exhibit cellular motility. In breast cancer, EMT facilitates invasion of surrounding tissues and correlates closely with cancer metastasis and relapse. We found previously that the candidate tumor suppressor hCLCA2 is a p53-inducible proliferation-inhibitor …
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Genomic Drivers of Cutaneous Squamous Cell Carcinoma Development
… prevention. Our knowledge of the molecular and cellular events that lead to the transformation of normal skin (NS) to AK and subsequently to cuSCC is very limited, thus representing a fundamental gap in our understanding of this progression.</p> <p>In order to identify novel targets for …
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Expression of Tetraspanin Markers in Benign Prostate Hyperplasia and Prostate Cancer // Експресия на тетраспанинови маркери при доброкачествена хиперплазия и карцином на простатната жлеза
През последните години бяха постигнати значителни успехи в по-прецизното стратифициране на пациентите с простатен карцином с цел избягване на ненужни терапевтични интервенции или недостатъчно агресивно лечение при привидно нискорискови тумори. Независимо от постигнатите резултати в изясняването на …
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Dissection of receptor functions through the generation of a tcu-PA cleavage resistant u-PAR: a u-PA independent active u-PAR
… has been widely studied in both systemic and cellular processes. Systemic roles for u-PAR include angiogenesis, inflammation and cancer while cellular roles include cell proliferation, survival, adhesion, migration, and localizing activation of plasminogen (Pg) (Blasi, Behrendt et al. 1990; …