Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"cellular memory"”.
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Regulation of cellular memory by non-coding transcription through Polycomb group response elements
… This task is accomplished by the so-called cellular memory. A paradigm to study the molecular basis of the cellular memory is the regulation of homeotic gene expression in Drosophila. A number of studies have shown that the cellular memory is an epigenetic mechanism based on the modification …
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The role of cellular memory modules in the determination and transdetermination of Drosophila melanogaster imaginal disc cells
… their interplay at chromosomal elements, termed Cellular Memory Modules (CMMs), by creating stable and inheritable chromatin structures. By this way, CMMs are able to remember the embryonic state of transcription of homeotic genes and to maintain it throughout development. I asked whether such …
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The Effects of Retinoids on Regenerating Axolotl Limbs
… rule is the inheritance by the blastema of a cellular memory of its position of origin, termed positional value. Recently, vitamin A and its derivatives (retinoids) have been found to proximalize positional value, causing duplication of stump structures in the regenerate. Positional values …
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Reconstructing experience of childhood cancer: a narrative inquiry
… (1968) Psychosocial Stages of Development and Cellular Memory, based on Porges’ Polyvagal Theory (1995). The narrative patterns that emerge are: relationships, identity and the embodied experience. The co-participant’s story is re-presented in a letter, accompanied by a poem, addressed to …
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Dysregulated DJ1-Mediated Translation in Alzheimer's Disease
… signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis continues still. The goal of this thesis is to take a bottom up approach to understanding the role of calcium in cellular memory …
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Decipher in situ signaling and complex genetics with cellular recording and combinatorial perturbations
… understanding of complex biological networks and cellular behaviors. The recent discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated (Cas) system from prokaryotic adaptive immune system demonstrated unprecedented genome editing efficiency and …
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Signal and noise propagation in genetic circuits
… also fundamentally limits signaling fidelity and cellular memory. Accurately predicting noise propagation in gene networks is thus crucial for reverse engineering natural networks and designing reliable synthetic genetic circuits. To determine how noise propagates through gene networks we measure, …
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Untersuchungen epigenetischer Eigenschaften des chromosomalen Elements Fab7 und der beteiligten Mechanismen in Drosophila melanogaster
… ihrer Zielgene ein, indem sie an sogenannte „Cellular Memory Modules“ (CMMs) binden. Diese DNA Elemente sind am Umschaltungen der Zielgene vom reprimierten in den aktivierten Expressionszustand maßgeblich beteiligt. Um die Vorgänge während der Umschaltung des CMM zu klären, wurde untersucht, …
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Feedback regulation in gene networks
Cellular genetic information is encoded in DNA. The passage of this information from DNA to proteins is regulated at multiple levels and each level gives cells the chance to control the structure and function of their components. Transcriptional regulation is an important part of this multi-level …
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Monogenetic Immune Dysregulation Syndromes and their Effect on the Plasma Cell Compartment
… that play a key role in maintaining humoral and cellular memory, are impaired within these patients. We characterised different features of plasma cells in immune dysregulated individuals via flow cytometry and ELISA in three different settings; I. 23 Patients with PID were recruited. Patients …
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Optogenetic dissection of the dopaminergic circuitry involved in memory consolidation
… ‘synaptic tagging-and-capture’ (STC) theory of cellular memory consolidation holds that memory persistence can be altered by prior or subsequent patterns of neural activity (Redondo & Morris 2011). The aim of this thesis was to develop a realistic model of everyday memory for mice and use the …
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Hysteretic properties of a modular positive feedback-based gene amplifier
… hysteretic response to an inducer, i.e. exhibit memory of a prior stimulus. Positive feedback in a genetic circuit potentially, but not necessarily, leads to bistability, and a bistable circuit will produce some degree of hysteresis [2]. Therefore, the purpose of this research was to determine …
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The molecular memory of exercise in skeletal muscle
… to skeletal muscle adaptations and encodes a memory of exercise in skeletal muscle. Using a novel TRAIN-DETRAIN-RETRAIN paradigm under control or high-fat diets, we investigated which adaptations occurred with exercise TRAINing, whether these adaptations persisted after DETRAINing and if they …
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The molecular memory of exercise in skeletal muscle
… to skeletal muscle adaptations and encodes a memory of exercise in skeletal muscle. Using a novel TRAIN-DETRAIN-RETRAIN paradigm under control or high-fat diets, we investigated which adaptations occurred with exercise TRAINing, whether these adaptations persisted after DETRAINing and if they …