Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"cellular invasion"”.
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THE ROLE OF OUTER MEMBRANE PROTEIN A IN ANAPLASMA MARGINALE CELLULAR INVASION AND ITS POTENTIAL AS A CROSS-PROTECTIVE ANTIGEN
… protein A (ApOmpA) as being critical for cellular invasion and is expressed during infection of mammalian but not tick cells. Disrupting ApOmpA-host cell interactions significantly inhibits A. phagocytophilum entry into host cells. ApOmpA and its A. marginale ortholog, AM854 (A. marginale …
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… that facilitate matrix degradation and cellular invasion. Although cellular lipids have been implicated in several aspects of invadopodia assembly and function, the contribution of de novo fatty acid and phospholipid synthesis has not been elucidated. The data in this dissertation …
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Cip4 and Src In Promoting The Migration and Invasion of Breast Cancers
Cellular invasion represents a critical early step in the metastatic cascade, and many proteins have been identified as part of an “invasive signature.” The non-receptor tyrosine kinase Src is commonly upregulated in breast cancers, often in conjunction with overexpression of EGFR. Signaling from …
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ROLE OF THE ENDOCYTIC PROTEIN EPSIN 3 IN MAMMARY GLAND TRANSFORMATION
… Endocytosis is a crucial mechanism regulating cellular signaling and its dysregulation is linked to cancer. We previously showed that the endocytic protein Epsin 3 (EPN3) is overexpressed in 50% of breast cancers (BC) and amplified in approximately 10% of cases. EPN3 overexpression correlates …
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Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes
… which share the common attributes of rapid cellular proliferation and invasion with tumor cells. The impact of VGLL1 in cancer has not been fully elucidated and no VGLL1-targeted therapy currently exists. The aim of this study was to evaluate the cellular function and downstream genomic …
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Role of Activated Macrophages and Pro-Inflammatory Cytokines in Placental Trophoblast Invasion and Fetal Outcome
The invasion of trophoblast cells into the uterine wall is an essential component of normal human pregnancy. These trophoblast cells transform the uterine spiral arterioles into high-flow, low-resistance vessels that supply the placenta to support fetal growth and development. Inadequate …
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Streptococcus equi subsp. zooepidemicus in New Zealand horses
… in the horse include biofilm formation and cellular invasion with the majority of strains tested in vitro, able to form biofilms and all tested strains capable of invasion. Bioinformatic analysis showed that the pangenome of S. zooepidemicus is open, which demonstrates the ability of species …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… that results in the stabilisation of an intracellular signalling molecule called β-catenin. In melanoma cells, Wnt/β-catenin signalling has been implicated as a key regulator of cellular invasion and metastasis. Using both transient and stable enhancement of Wnt/β-catenin signalling, I have …
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A study of the expression and cellular function of the human FAM111B gene
… study sought out to provide insights into the cellular function of FAM111B and to investigate the pathological effect of the FAM111B Y621D mutation. First, bioinformatics studies coupled with quantitative PCR and Western blots analysis were employed to assess FAM111B gene and protein expression …
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Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
… progression through EMT induction. Remodeling of cellular junctions, including gap junctions, is critical to acquiring migratory and invasive characteristics during EMT. The gene GJA1 encodes for Connexin43 (Cx43), the most ubiquitously expressed gap junction protein where altered regulation of …
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The Expression and Function of Wilms' Tumor 1 in Malignant Glioma
… resistance to apoptosis, and increased cellular invasion. We aimed to thoroughly characterize the expression pattern of Wilms' tumor 1 in human malignant glioma and discern its function in this complex disease process. We screened a large sample of established human malignant glioma cell …
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Decoding novel virulence strategies in Fusobacterium invasion and survival
… of genes predicted to be involved in host cellular invasion and survival. In this work, we identified a novel small adhesin, FadA2, that played a significant role in the invasive ability of F. nucleatum ATCC 25586 to colorectal cancer cells. This dissertation also sheds the first insight …
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Investigation of the molecular mechanisms underlying the invasive phenotype in a panel of lung cancer cell lines
… a group of genes, including microRNAs, in cancer invasion. DLKP mildly invasive cell line derived from a non-small cell lung carcinoma and its Adriamycin resistant variant DLKPA highly invasive were used in this study to evaluate the roles of differentially expressed mRNAs and microRNAs. We …
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Anaplasma phagocytophilum remodels its host cell-derived vacuole into a protective niche by redecorating the vacuolar membrane with select Rab GTPases and bacterial proteins
Anaplasma phagocytophilum is an obligate intracellular bacterium that infects neutrophils to cause the emerging tick-transmitted disease, human granulocytic anaplasmosis (HGA). Following entry, the pathogen replicates within a host cell-derived vacuole that fails to mature along the endocytic …
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Effect of resection of localised pancreatic cancer on tissue-factor promoted pathways of thrombosis, cell invasion and angiogenesis
… biological link between cancer haemostasis, cell invasion and angiogenesis remains unclear. These three indices may be driven by PC cells directly, be a reflection of the individual tumour stromal microenvironment and/or a result of the inflammatory response of the host. The hypothesis of the …
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Investigation into synthetic protease-sensitive hydrogels as siRNA nanoparticle delivery vehicles.
… degradable PEG hydrogels that rely on cellular invasion for their degradation might enable the release of entrapped RNAi agents to surrounding cells as well as transfection of invading cells. The cationic polymer poly(ethyleneimine) (PEI), was used as a tool to investigate the PEG …
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Expression, inhibition and in silico modelling of human neuronal nitric oxide synthase
… while iNOS is inducibly expressed in response to cellular invasion by a pathogen. nNOS, which was the isoform targeted in this work, is constitutively expressed in the brain and central nervous system, where the NO it produces regulates many neurogenic pathways. Over activation of nNOS leads to …