Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"cellular health"”.
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STUDYING THE INTERACTION OF NANO- & MICROPLASTICS WITH ENTEROVIRUS AND THEIR CYTOTOXICITY ON HUMAN LUNG CELL LINE
… contaminants and their potential long-term cellular effects. This study investigated the interaction between enterovirus D68 (EV-D68) and charged nano- and microplastics, as well as the chronic effects of positively charged mixed polymer nanoplastic particles on a human lung cell line. …
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Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and Its Impact on Proteostasis
… protein homeostasis is essential for cellular health. During times of protein stress, cells deploy unique defense mechanisms to achieve resolution. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response (MCSR), a unique stress response …
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Investigating the endocrine disrupting potential and cytotoxic effects of packaging leachates and plasticisers
… contributing to a wide range of adverse health effects. Plastic packaging and films have been identified to leach chemicals/compounds into food and beverages which can negatively affect the consumer and/ or environment. Compounds which leach out of plastic materials often have hormonal …
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Mitochondrial response to axonal injury
… shown to be dysfunctional and detrimental to cellular health. Interestingly, transection of axons within the sciatic nerve resulted in mitochondrial fission but did not result in the fragmentation of mitochondria. Inhibition of Drp1, the GTPase responsible for mitochondrial fission, using a …
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Leveraging Protein Homeostasis as a Disease-modifying Strategy
… (proteostasis) is a fundamental determinant of cellular health, and its impairment is causally linked to a wide range of human diseases. While extensive eHort has gone into characterising how the proteostasis network (PN) maintains proteins in their functional states, more work is needed to …
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Mitochondrial Fission After Traumatic Brain Injury
… Loss of mitochondrial function disrupts normal cellular processes in the brain, as well as impedes the ability for repair and recovery, creating a vicious cycle that perpetuates damage after injury. To maintain metabolic homeostasis and cellular health, mitochondria constantly undergo regulated …
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Development of glucose valves for metabolic engineering applications in E. coli
… potential to help meet the energy, material and health needs of tomorrow. Through the reactions of cellular metabolism, microbes are an attractive option for the sustainable production of commodity and enantiopure specialty chemicals. One outstanding challenge, however, is the engineering of …
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Cytochrome P450 whole cell biohydroxylation of alkanes
… in aqueous media required to maintain whole cell health. Alkanes applied were immiscible with the aqueous phase, resulting in a ‘2-Liquid Phase System’ (2LPS). Alkane accessibility to the enzyme in the whole cells significantly constrains scalability of biocatalysis due to transfer across the …
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A Bacterial Metabolite Causes Changes in Neurodegeneration and Aging Via Bioactivation and Hormesis in Caenorhabditis Elegans
… factors contribute to the acceleration of cellular damage. This multi-causal deterioration of cells renders individuals more susceptible to diseases.Parkinson's Disease is classified as an idiopathic disorder, with 90% of cases sporadic in nature. Increasing evidence points towards the …
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Factors and mechanisms of archaeal transcription termination and DNA repair
… both temporally and spatially to ensure cellular health in dynamic environments. Regulation of RNA synthesis in response to internal and environmental stimuli is typically achieved through interactions with RNAP at all stages of the transcription cycle- initiation, elongation, and …
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Biochemical Studies of the ER Resident Kinase PERK and Implications for Local Translational Control
… PERK signalling which may be relevant to cellular health and disease, in particular, neurodegenerative disease, the PERK-protein interactome was examined using mass spectrometry. This led to the identification of the mitochondrial protein, ATAD3A, as a PERK kinase insert loop interactor. …
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Deficiency in Parkinson's Disease risk gene CD38 as it relates to glial function: dysregulation of astrocyte genes and bioenergetics as a result of CD38 deficiency
… system (CNS) inflammatory status and means of cellular energy production typically precede pathological indications. In the brain, CD38 expression is most enriched in astrocytes in BG regions, including substantia nigra, midbrain, and striatum. However, it is not known how CD38 deficiency may …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
Cellular protein homeostasis is achieved by a delicate network of molecular chaperones and various proteolytic processes such as ubiquitin–proteasome system (UPS) to avoid a build-up of misfolded protein aggregates. The latter is a common denominator of neurodegeneration. Neurons are found to be …
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The Role of Compartmentalized Metabolism in Cellular Metal Homeostasis
… without iron. While the list of iron's vital cellular functions is extensive, iron is also quite cytotoxic. Thus, great pains have been taken, at the gene regulation level, to assure that a cell has sufficient iron to copy its genome and power its mitochondria but not too much to damage its …
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On the aberrant nature of tau protein: biophysical approaches to characterise and target aggregation in neurodegeneration
… growth, underscores the significance of tau in cellular health. Although the protein is central to many fundamental processes, tau is also heavily implicated in the onset and spread of neurodegenerative conditions, collectively known as tauopathies. As a result, this added complexity muddles our …
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Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
Diabetic retinopathy (DR) is the most frequently occurring microvascular complication of diabetes mellitus, where the later stages of the disease are often is chaemia driven which can result in severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, …