Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"cellular entry"”.
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RNA transmission and expression from inert HIV candidate vaccine virus-like-particles
… systems are potent stimulators of both cellular and humoral immune responses in animal models. The encapsidation of large concentrations of random cellular RNA species is known to accompany the assembly of HIV virus particles. This RNA plays a crucial role by serving as a molecular …
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Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system.
… time, an investigation into the mechanism of cellular entry via the polyamine transport (PAT) system was studied. However, none of the BNIPP derivatives utilised the MGBG-specific PAT system, suggesting that BNIPP derivatives utilise other modes of cellular entry. Two BNIPP derivatives, …
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Identification and Characterization of the Helicobacter Pylori Vacuolating Cytotoxin Receptor
… but the molecular basis of toxin binding and entry are complex, and have been poorly understood. In particular, the identity of the receptor that VacA binds on the surface of host cells, as well as the importance of the receptor for toxin entry into human cells, were the major gaps in …
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The role of scavenger receptor B-I in hepatitis C virus attachment and entry.
… often culminating in conditions such as hepatocellular carcinoma. HCV has a propensity to persist, with 70-80% of infected individuals failing to clear the virus. Recent evidence suggests that HCV entry is dependent on at least three cellular entry factors: CD81, Scavenger Receptor B-I (SR-BI) …
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Application of Genetically-Encoded Photoactivatable Crosslinkers to Map Ligand-Binding Sites on G Protein-Coupled Receptors
… are dynamic membrane proteins that bind extracellular molecules to transduce biological signals. Although GPCRs represent the largest class of targets for therapeutic agents, ligand-binding sites have been precisely defined for only a small percentage of the receptors in the human genome. A …
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Great Expectations: Phosph(On)Ate Prodrugs In Drug Design—Opportunities and Limitations
… charge and easily enable cell permeability. Upon cellular entry, the promoieties are enzymatically or environmentally cleaved to unveil the active pharmacophore. A secondary and conventionally overlooked function of prodrugs is their ability to mediate cell- and tissue-specific drug localization. …
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A Recombinant Vesicular Stomatitis Virus Expressing the Junin Virus Glycoprotein for Arenavirus Countermeasure Development
… all chimeric GPs were adequately processed intracellularly, packaged into a rVSVΔG-GFP virion from the plasma membrane, and capable of cellular entry. Our findings suggest that these chimeric GPs may be good candidates to move forward into a rVSV vaccine vector for evaluation of protective …
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Cryo-EM reveals how adeno-associated virus engages its receptor AAVR and an investigation of the GPR108 ectodomain
… and there are still unknown factors in AAV cell entry, uncoating, and host protein interactions. Furthermore, its use in gene therapy can be optimized with more accurate cell targeting and immune evasion. Being a non-enveloped virus, the protein shell of AAV is responsible for all of the host …
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Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis.
… to the destruction of the BBB, facilitating cellular entry. Increased expression of MMP2 and MMP9, amongst others, has been shown previously in autopsied MS brain, and increased levels of the cell surface peptidase CD26, expressed by T cells and endothelial cells, have been linked to disease …
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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
… membrane proteins that bind to specific extracellular ligands, such as hormones or neuromodulators. The active receptor-ligand complex then engages with a heterotrimeric G protein on the cytoplasmic surface of the plasma membrane to facilitate a change in the concentration of an intracellular …
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The Role of Alternaria and its Major Allergen, Alt a 1, in the Pathogenesis of Allergic Airway Disorders
Chronic exposure to the ubiqutious airborne fungus, Alternaria alternata, has long been implicated in the development and exacerbation of human allergy and asthma. Alt a 1 was identified previously by several groups as the major allergen secreted by A. alternata, due to its IgE-specific reactivity …
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Investigation of the intracellular trafficking pathways of the dermonecrotic toxin family
The aim of this thesis is to further define the entry and trafficking pathways of the dermonecrotic toxin family composed of related AB toxins whose members induce dermonecrosis upon injection into animal skin. The dermonecrotic toxins Pasteurella multocida toxin (PMT) from Pasteurella multocida …
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Targeting the N-myc oncoprotein using nanobody technology
… includes c-myc, N-myc and L-myc, control major cellular processes such as proliferation and differentiation by integrating upstream signals and orchestrating global gene transcription. They do this largely through dimerising with Max, which together bind to enhancer (E)-box elements in DNA. Myc …