Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"cellular dysfunction"”.
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Nutraceutical modulation of lipotoxicity and the development of a tool to monitor palmitate induced sub-cellular dysfunction.
… of a tool to monitor palmitate induced sub-cellular dysfunction. - by Dean Frederick Ashley. Over 64.3% of the UK are currently overweight or obese according to the NHS survey, a number that has continued to increase throughout the beginning of the 21st century. Inherently this increases the …
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Early hippocampal dysfunction in a mouse model of dementia with Lewy bodies: Mechanisms of cellular dysfunction caused by alpha-synuclein accumulation
Dementia with Lewy bodies (DLB) is a devastating neurodegenerative disease, accounting for 5% of all dementia cases, for which there is no cure. Whilst there are currently many different animal models currently available for researchers studying PD, there are comparatively fewer DLB-specific mouse …
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Defining the role(s) of non-classical tumour suppressor Wwox in cellular function using Drosophila melanogaster genetic modelling
… cancer. WWOX has been implicated in various cellular pathways, however the role of WWOX in tumourigenesis is not yet fully defined. There is therefore a need to determine the normal function(s) of WWOX and how perturbation of these roles is likely to contribute to cancer. A model was …
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Characterization of Palmitic Acid Induced Lipotoxicity in Schwann Cells
… to lipid overload that has been associated with cellular dysfunction leading to cellular death. The mechanism of lipotoxicity and its impact on the nervous system is critical as it can lead to debilitating neurological conditions. This study examines key cellular events induced by palmitic acid …
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Investigating the aggregation of TDP-43 in models of Amyotrophic Lateral Sclerosis
… of pathological aggregate species and cellular dysfunction. We have characterized stable cell models expressing EGFP-TDP-43 to identify key pathological hallmarks of disease at the molecular level, using confocal microscopy imaging. Using various chemical stress inducers to recapitulate …
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Interplay of Iron and Hydrogen Sulfide in Pathophysiology of Vascular Damage
… of studies spanning molecular, mitochondrial, cellular, and whole-animal levels. The molecular basis of H₂S–iron interactions in vascular smooth muscle cells was defined, demonstrating that endogenous H₂S upregulates ferritin expression, balances apoptosis–autophagy signaling, and protects …
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Quantitative Proteomics Analysis of Differentially Expressed Proteins in Aβ(17-42) Treated Synaptosomes
… and RNA, which can lead to oxidative damage, cellular dysfunction, and can ultimately cause cell death. Down syndrome (DS) is the most common form of chromosomal abnormality found in live-born infants. DS patients have an extensive deposition of Aβ(17-42) peptide, which could contribute to …
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Homeostasis of metastable proteins in Alzheimer's disease
… disorders characterized by extensive neuronal dysfunction associated with the misfolding and aggregation of a specific set of proteins, including amyloid plaques and neurofibrillary tangles in AD. One promising avenue for progress in the field is to improve our understanding of the mechanisms …
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Identification and characterisation of novel interactors of surfactant protein C
… plasma membrane and causes alveolar type 2 (AT2) dysfunction via a poorly understood toxic gain-of-function. Understanding the mechanisms of SFTPC trafficking and their interactors in health and disease is crucial to defining how pathogenic variants induce cellular dysfunction. To investigate …
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Understanding the molecular bases of neurodegeneration: From the structural characterisation of the aggregates to the establishment of an iPSC-derived neuronal model
… pathogenesis of AD, and to be a main source of cellular dysfunction. In the first part of the thesis, we characterize the physio-chemical properties and the biological activity of oligomeric populations resulting from the aggregation of a set of four Aβ40 variants, each carrying a familial …
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Tool Development for Studying and Manipulating Peptide-MHC Interactions in a Globally-Representative Manner
… T cells. In this way, T cells are able to sense cellular dysfunction associated with disease, such as the presence of pathogen-derived peptides. The ability to assess and predict peptide-MHC binding is, therefore, an important component of understanding and engineering immune responses. …
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Early Onset Alzheimer’s Disease Markers in Mouse Hippocampus Unveiled by Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy
… changes as potential drivers of persistent cellular dysfunction after radiation exposure, specifically concentrating on the CA1-3 regions of the hippocampus and the prefrontal cortex due to their role in cognitive functions. Thirteen-week-old mice underwent whole-brain radiation at …
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The Thioredoxin Trx-1 Regulates The Major Oxidative Stress Response Transcription Factor, Skn-1, In Caenorhabditis Elegans
… level and, if left unresolved, can lead to cellular dysfunction and organismal disease. Sophisticated detoxification systems, characterized by a battery of enzymatic antioxidants, are utilized to neutralize ROS thereby reducing stress. However, ROS are also purposefully produced by …
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… and aging embody two related processes driving cellular dysfunction. In either case, environmental stimuli and genetically encoded regulatory mechanisms affect cellular homeostasis and influence adaptation. Phosphatases represent master regulators of stress signaling and modulate cellular …
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Nrf2 in metabolic related inflammation in the brain
… These may be indicative of OS-induced cellular dysfunction and is supported by an aggravated response to LPS, which potentiates IL-1β production. Furthermore, despite an attenuated LPS response following the induction of tolerance, <i>Nrf2<sup>-/-</sup></i> mice maintain glial cell …
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Regulation of Metabolic Stress-Induced snoRNAs
… is associated with oxidative stress and organ dysfunction and plays an important role in diabetic complications. While a number of stress responses have been implicated, the precise molecular mechanisms linking lipid accumulation and cellular dysfunction are not fully understood. To elucidate …
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Excessive iron accumulation mediated oxidative stress and β-cell dysfunction via perturbations of insulin secretion in MIN6 cells
… of T2DM. Reactive oxygen species (ROS) mediated cellular oxidative damage has been implicated in cellular dysfunction in various organs and disease states. Exposure to high level of glucose during hyperglycaemia has been co-related to ROS generation and oxidative stress in β-cells. In the initial …
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Islet Dysfunction In Diabetes
… the mechanisms involved in pancreatic beta cell dysfunction in diabetes, specifically in elucidating the role of endoplasmic reticulum [ER] - mitochondria axis, executioner caspases and their target substrates; specifically nuclear lamins. </p> <p>Results obtained from our studies in pure beta …
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Gene-regulatory circuitry of disease risk and progression
… through a remarkable diversity of cellular and functional outcomes across the human body, primarily through epigenetic organization and gene regulation. Genetics is a powerful tool to shed light on genes involved in disease, but we need maps of gene regulation and function at the …
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Controlled release films and functional surfaces targeting infection, inflammation, and bleeding
… delivery has the potential to effectively treat cellular dysfunction while avoiding drug toxicity. This thesis focuses on developing degradable layer-by-layer (LbL) assembled multilayer films as local delivery coatings to address infection, inflammation, and bleeding. These films were engineered …
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