Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"cellular development"”.
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Probabilistic modelling of cellular development from single-cell gene expression
… how to model transcriptional changes during cellular development. The general forms of expression changes with respect to development leads to nonparametric regression models, in the forms of Gaussian Processes. I used Gaussian process models to investigate expression patterns in early …
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Cellular Development of the Golden Delicious Apple From Blossom to Maturity
Made available in DSpace on 2014-12-04T19:49:22Z (GMT). No. of bitstreams: 1 0006917.pdf: 6944095 bytes, checksum: 51c01c23454acd6f31fcdf96dd524e64 (MD5) Previous issue date: 1953
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Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development
… NBs and NETs reflected a certain stage of neural development characterized by their expression of discrete sets of regulatory genes.
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Intracellular distribution of nitrogen during synchronous growth of Chlorella pyrenoidosa
… was developed which yielded 3x as much cellular material as previous culturing methods for <i>C. pyrenoidosa</i> in the same time period and in less than one-tenth the culture volume. Cellular growth parameters increased exponentially throughout the cell cycle of <i>C. pyrenoidosa</i> …
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Thymidylate kinase activity during synchronous growth of Chlorella pyrenoidosa
… determine the activity of the TMP kinase during cellular development. It was observed that the apparent enzyme activity was closely correlated with the rate of DNA biosynthesis. During the period of nuclear division, when DNA synthesis is at its maximum apparent TMP kinase activity is highest. …
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Engineering hydrogel environments to direct cell fate
… in recent years as a means to investigate cellular level processes. An area that has shown promising application of hydrogel materials has been in the study of stem cell development. Proven that the microenvironment of the stem cell plays a critical role in its development, hydrogels can …
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Stress in a Microgravity Bioreactor
This project involves the design and development of a cell stretching bioreactor device that can work in conjunction with a Random Positioning Machine (RPM) apparatus. Microgravity environments, such as in space, have been shown to induce alterations in cellular development due to inadequate …
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Investigating the Post-Translational Modification of Notch1 Intracellular Domain: From Proteolytic Cleavage to Mass Spectrometric Profiling
… plays a pivotal role in cell fate determination, cellular development and its dysregulation has been widely associated with cancer. Thus, post-translational modifications (PTM) further fine-tune Notch activity by modulating its trafficking, stability, and transcriptional dynamics. This thesis …
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Implementation of Wideband Multicarrier and Embedded GSM
The Global System for Mobile (GSM) cellular standard, having been in existence for over two decades, is the most widely deployed wireless technology in the world. While third generation networks and beyond, such as Universal Mobile Telecommunications System (UMTS) and Long Term Evolution (LTE), are …
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Auditory Processing Deficits in MSH2-KO mice are linked to Aberrant Inhibitory Neuron Function in the Thalamic Reticular Nucleus
<p>DNA repair mechanisms are crucial for both cellular development and function. One highly conserved DNA repair factor is Mut-S Homolog 2 (<em>Msh2</em>), which corrects base-base mismatches and insertion/deletion loops. In humans, defects in this repair pathway are linked to diseases that have …
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Total starch and amylose levels during synchronous growth of Chlorella pyrenoidosa
… capacity of the cell during this stage of development. The fact that the photosynthetic rate approached its lowest level of the cell cycle during this stage of cellular development, and that at the same time the endogenous respiration rate accelerated, leads to the inference that a …
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Analysis of Exome Sequencing in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the type of cancer difficult to classify and analyze despite the high occurrence, because it displays a high level of tumor heterogeneity with complex etiology. For unbiased analysis of HCC with diverse tumorigenic backgrounds, a genomewide study that does not …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
Exosomes/extracellular vesicles (EVs) are cell-derived mixed-populations of vesicles released by almost all cells into the intercellular microenvironment, ending up in the circulation. Exosomes contain proteins, RNAs and lipid molecules reflecting the status of the parental cell at the time of …
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Development and application of tools for glycan characterization
… things because they function as key elements of cellular membranes and extracellular spaces by mediating cell-cell communication, transduction pathways, and cellular development, function, and survival. Because glycans are secondary gene products that depend on the availability of sub-cellular …
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
… environments and can cause damage to all cellular components, including our DNA. If left unrepaired, methylated DNA can cause mutations, cell death, and disease, such as cancer and neurodegeneration. The majority of DNA lesions caused by methylating agents are repaired by the base excision …
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Investigation of transcription factor binding at distal regulatory elements
Cellular development and function necessitate precise patterns of gene expression. Control of gene expression is in part orchestrated by a class of remote regulatory elements, termed enhancers, which are brought into contact with promoters via DNA looping. Enhancers typically contain clusters of …
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Rethinking Plant-Based Materials Production: Selective Growth of Tunable Materials Using Cell Culture Techniques
… (1) establishing knowledge to effectively direct cellular development, (2) devising and demonstrating mechanisms to direct material form, and (3) relating cellular-level properties to emergent material characteristics to allow tunable and predictable material outcomes. First, using newly proposed …
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Control of Aspartate Transcarbamylase activity by Norit-A adsorbable compounds during synchronous growth of Chlorella pyrenoidosa
… can be hypothesized that periodism in the intracellular level of a given metabolite must be accompanied by periodism in the active level of one or more of the enzymes responsible for the synthesis or breakdown of this metabolite. Synchronized cultures of microorganisms afford a unique tool for …
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Cross-kingdom microRNA detection and influence of diet on endogenous equine microRNAs
… that were differentially expressed on day 23. Cellular development, growth and proliferation were predicted to be the primary networks associated with these differentially expressed miRNAs. Finally, 11 miRNAs were different at day 23 in horses fed alfalfa. Ingenuity pathway analysis (IPA) …
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CsgA, a putative signal molecule of the myxobacterium Stigmatella aurantiaca involved in fruiting : characterization of the csgA gene and influence of csgA inactivation on development
Cell-cell interaction is a prerequisite for multi-cellular development and cellular differentiation of the Gram-negative bacterium Stigmatella aurantiaca. For the elucidation of the temporal and spatial coordination of the physiology and motility of the cells during development, isolation and …
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