Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 277 for “"cellular biology"”.
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Quantitative phase imaging for cellular biology
Measuring cellular level phenomena is challenging because of the transparent nature of cells and tissues, the multiple temporal and spatial scales involved, and the need for both high sensitivity (to single cell density, morphology, motility, etc.) and the ability to measure a large number of …
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Fast Phase Dispersion Microscope : a new instrument for cellular biology
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.
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Using genetic and genomic approaches to understand haematopoietic cellular biology and dysregulation in disease
… treatment and methods to understand fundamental biology. Many different approaches can be applied to attempt to resolve the mechanisms through which sequence variation disrupts downstream biological processes, which I discuss and apply in this thesis. Specifically, I use tractable haematopoietic …
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Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor
… clinical medicine and basic science questions in cellular biology and metabolism. The spectrum of diseases which present with antibodies directed against cellular constituents is vast although certain features of these conditions imply common aspects which may, furthermore, be of some diagnostic …
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Using light to control and investigate cell biology
… tool for the interrogation of molecular and cellular biology. Beyond its use in microscopic applications, light has emerged as an attractive modulator of cellular function. Within the last two decades, scientists have begun to harness the power of light and light-sensitive moieties to …
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United States stem cells research boundaries
… particularly in fields such as molecular and cellular biology in which the materiality of research renders the process of replication and validation more complex. Scientific infrastructure has many interconnecting elements such as the ability to exchange material used in experiments, the …
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Exploring the mechanism of SHP2 and EGFR/HER2 cooperation in breast cancer cell signaling
… In this report, I employed molecular and cellular biology techniques to further elucidate the role of SHP2 downstream of receptor tyrosine kinases in breast cancer cell lines. In this way, I was able to contribute knowledge to how SHP2 controls triple-negative cell motility. In addition, …
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Cyclic matter(s) in architecture
… and reconstitution. From geophysics to cellular biology, processes across scales exhibit cyclic behavior, providing a framework toward understanding both the physical and the metaphysical potential of death as a process. This project interrogates the rituals and material of death through …
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Neuro-Silicon Interface of a Hirudo medicinalis Retzius Cell Integrated with Field Effect Transistor
… focus of this thesis was to measure the intracellular voltage of a living neural cell using a silicon transistor. The coupling of neurological tissues with silicon devices is of interest to the fields of neurology, neuroscience, electrophysiology and cellular biology. In previous work by Peter …
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Deep Learning Approach for Cell Nuclear Pore Detection and Quantification over High Resolution 3D Data
… 3D microscopy data is critical for cellular biology and disease research. This thesis introduces a deep learning pipeline crafted to automate the segmentation and quantification of nuclear pores from high-resolution 3D cell organelle images. Our aim is to refine computational methods …
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A microfluidic platform for combinatorial experiments
Experiments in biology are often combinatorial in nature and require analysis of large multi-dimensional spaces, but the scales of these experiments are limited by logistical complexity, cost, and reagent consumption. By miniaturizing experiments across nanoliter-scale emulsions that can be …
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Smooth Flow Control for On-Chip Pneumatic Micropumps
Advancements in cellular biology, microfabrication methods, and the field of microfluidics allow biologists to closely replicate in vitro environments on organ-on-a-chip devices. In order to reproduce physiological conditions and processes as accurately as possible, it is necessary to generate the …
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Mitochondrial parts, pathways, and pathogenesis
Mitochondria are cellular compartments that perform essential roles in energy metabolism, ion homeostasis, and apoptosis. Mitochondrial dysfunction causes disease in 1 in 5,000 live births and also has been associated with aging, neurodegeneration, cancer, and diabetes. To systematically explore …
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Characterization of Cellular and Genomic Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells
… for chemoprevention. We investigate herein the cellular and genomic effects of 1,25 dihydroxyvitamin D3 (the metabolically active form of vitamin D3) on the prostate progenitor/stem cell and discuss their implications for prostate cancer chemoprevention. We used genomic microarrays to analyze …
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Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
… highly innovative and influential field of biology and medicine. Protein acetylation and deacetylation, two key epigenetic regulatory mechanisms, are mediated by histone acetylase transferases (HATs) and histone deacetylases (HDACs), respectively. To date, the vast majority of studies on …
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Photonic Tweezers for Optical Manipulation of Cells and Tissues
… studies for their application in cellular biology.<br/><br/>Regarding the application of tweezers in tissues, I demonstrated their use for the study of tension in developing chick embryos. At about 6h from the egg’s deposition, the chick embryo initiates gastrulation: the embryo …
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Post-Replicative Resolution of Under-Replication
… stalling. Interdisciplinary approaches between cellular biology and biophysics predict that replication of the genome is routinely incomplete in G2, even in the absence of external stressors. The frequency of converging replication forks that never terminate due to irreversible stalling (double …
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Polyphosphate Modification of Human Proteins and a New Mechanism for Regulating Super-Enhancer Activity
… as a multifaceted regulatory molecule in human cellular biology, identified many human proteins containing lysine-rich regions as polyP targets and uncovered polyP’s role in manipulating super-enhancer complex to regulate gene expression. Through a comprehensive screen of 57 lysine-rich human …
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Development of CRISPR/Cas9-based gene drive biotechnology in S. cerevisiae
… the fundamental aspects of molecular and cellular biology. It also can be used to evaluate the technical feasibility of new technologies in eukaryotic cells. In our lab, we aimed to use Saccharomyces cerevisiae as a model to develop CRISPR/Cas9-based gene drive biotechnology. The …
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The interaction of angiocidin and tissue transglutaminase
… the interactions between the cell and the extracellular matrix (ECM). Cell adhesion molecules are found on the surface of all cells and play a role in cell-cell and cell-extracellular matrix interactions. Tissue transglutaminase is ubiquitously expressed in various tissue types, occurs in both …
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