Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"cellular aging"”.
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Romantic conflict, interpersonal mindfulness, and cellular aging
… Laurent et al., 2013) including biological and cellular aging processes measured through telomere length (Rentscher et al., 2020). Despite established associations between romantic conflict and health outcomes (Cummings et al., 2007), empirical evidence has yet to emerge supporting a link …
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Role of Reactive Oxygen Species and Altered Biochemical Pathways in Cellular Aging
No abstract prepared.
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Towards precision medicine in psychiatry: investigating the contribution of cellular aging, pleiotropy and gender differences in psychiatric disorders and pharmacological response
… investigation of molecular markers related to cellular aging (telomere length) and inflammation in predisposition to severe mental disorders and response to psychotropic treatments. In addition, we present different studies aimed at identifying genetic loci shared between severe mental …
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Telomere and Telomerase Dynamics in Human T Lymphocytes
… that permits cells to divide indefinitely while cellular aging is characterized by cells ceasing to divide. It is believed that senescence may have evolved as an anti-cancer protection mechanism in long-lived species such as humans. Therefore, cancer and aging are essentially opposite ends of the …
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A deep learning approach to estimate replicative lifespans from yeast cell images
… cerevisiae is an important model organism for cellular aging. A common metric for determining the lifespan of budding yeast cells is the replicative lifespan (RLS), how many times a mother cell divides in its lifetime. Traditionally, determining the RLS of yeast cells is a tedious manual …
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The Effects of Cell Culture Oxygen Levels on the Replicative Senescence Processes of Primary Human Fibroblasts
Serial passaging of primary human fibroblasts leads to the formation of non-dividing senescent cells by a process termed replicative senescence. This tissue culture-based methodology is currently used as a model system to determine the underlying mechanisms of in vivo cellular aging and tumor …
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Lessons from a rare disease
Progeria is a genetic aging disease of childhood affecting an estimated one in four to eight million births. Children with progeria experience a range of developmental disorders and aging-like symptoms, including wrinkled and discolored skin, stunted growth, visible veins, fat loss, hair loss, bone …
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Evaluating Determinants of Mitochondrial Mutagenesis and their Intersections with Cell Fate
Mitochondria are critical components of cellular metabolism as mediators of oxidative phosphorylation. As semi-autonomous organelles, mitochondria possess their own DNA (mtDNA) which encodes elements of the electron transport chain (ETC). Aberrations in the mitochondrial genome are associated with …
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Defining Multiple Steps in Human Telomere End Processing
… length homeostasis with implications in both cellular aging and cancer.
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The effects of cellular quiescence on the antioxidant defense enzymes of bovine embryonic lung fibroblasts: a survey
The aging phenomena is a process to which all organisms eventually succumb. The universality of this phenomena suggests that there may be one overwhelming factor involved. The exact biochemical basis of aging is still unclear. Free radicals such as the superoxide radical (O₂⁻) and the hydroxyl …
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A Critical Review of Telomerase Biology and Model Systems for the Study of Telomerase
… promise in uncovering the molecular process of aging and the treatment of cancers. Studies have shown that telomere shortening is directly linked to cellular aging and that telomerase expression is found in over 85% of human cancers, including 95% of all advanced malignancies. Development of …
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Insights Into Mitochondrial Genetic and Morphologic Dynamics Gained by Stochastic Simulation
… mutations in mammalian cells are implicated in cellular ageing and encephalomyopathies, although mechanisms involved are not completely understood. The mitochondrial genetic bottleneck has puzzled biologists for a long time. Approximate models of genetic bottleneck proposed in the literature do …
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
… later, thought to contribute to molecular and cellular organismal aging. There are several studies that demonstrate the importance of the GH/IGF axis in longevity, aging and cellular senescence. One primary component of the IGF signaling involves IGFBP-3. It is well documented that IGFBP-3 …
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Testing the T-loop Model of Telomeric End Protection
… they are often thought about in the context of cellular aging, their most important role is actually to protect the end of the DNA from being mis-interpreted as a site of DNA damage. Telomeres are thought to accomplish this through the action of shelterin. Shelterin is a multi-protein complex …
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Proteomic Analysis of Human Mesenchymal Stem Cell Aging during serial sub-culture
… frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells can be expanded in vitro for only limited passage numbers before they reach a senescent state. Previous studies have shown that long term …
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A simple and effective model to study insulin resistance in obesity and diabetes and the processes and mechanisms of in vitro aging using lymphocyte culture
… and effective system to study metabolic and cellular processes required for cellular growth in vitro. In this study, we demonstrate that lymphocyte culture can be used as a model system to study the mechanism of insulin resistance (obesity/diabetes) as well as the process of aging of cells …
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Adiciones 1,4-conjugadas a deshidroalaninas quirales para la síntesis de aminoácidos no naturales
… which histidinoalanine, which is related to cellular aging, can be highlighted. On the other hand, β-seleno-α-amino acids can also be obtained, which present great interest thanks to their antiviral and anticancer activities. In this case, we can highlight the synthesis of a mimetic …
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Social-Demographics, Health Behaviors, Telomere Length In Mexican-American Cohort and Circulating Dna Methylation In Bladder Cancer
… leukocytes is not only a potential indicator of cellular aging that has been linked to stressful life experience and health behaviors, but also a prognostic marker for major chronic diseases; however, such study has never been done among adult Mexican Americans. In this current study, we examined …
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DIETARY BIOACTIVES IN THE MODULATION OF METABOLIC, FUNCTIONAL AND AGING BIOMARKERS
… regulation, intestinal function, and healthy aging. In particular, dietary (poly)phenols and xanthines have gained attention for their potential benefits on several metabolic and functional biomarkers. However, the mechanisms are not completely understood and the evidence in humans are still …