Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 59 for “"cellular adhesion"”.
-
Promoting cellular adhesion to glass polyalkenoate cement by biopolymer addition
… and in biologically modified forms to promote cellular attachment. Where results indicated this was appropriate to do so. <br/>In addition the properties of surface hardness, strength [compressive, diametral, flexural (3 point and biaxial)], diametral fatigue strength and adhesive bond strength …
-
Towards a microfluidic disease detection deviced based on cellular adhesion differences
… developing microfluidic devices that exploit the adhesion differences between cell states and cell types to rapidly count cells of different types without the need for labels. There are two avenues in which to explore cell adhesion differences with these devices, the first is a net electrostatic …
-
Stochastic dynamics of adhesion clusters under force
Adhesion of biological cells to their environment is mediated by two-dimensional clusters of specific adhesion molecules which are assembled in the plasma membrane of the cells. Due to the activity of the cells or external influences, these adhesion sites are usually subject to physical forces. In …
-
Engineering biomaterial surfaces with N-cadherin
… is a key protein that is responsible for cellular adhesion to neighboring cells in mesenchymal tissues. It plays a significant role in neural development, regeneration, and pathological processes. Recently, efforts were increasingly made to better understand biological function of …
-
Osteoblast-like cell response to titanium coated with co-immobilized Elastin-like polymers containing integrin-binding and Statherin-derived biomimetic peptides
… nearly half of all integrins and is important in cellular adhesion. SNa15 is a modified peptide sequence from the N-terminus of the salivary protein statherin, which has been shown to be important in calcium phosphate mineral binding and nucleation. The aim of this study was to compare the in …
-
Cell engineering of human bone monolayers and the effect of growth factors and microcontact printed ECM proteins on wound healing. The role of ECM proteins, TGF¿-1, 2 and 3 and HCl/BSA in cellular adhesion, wound healing and imaging of the cell surface interface with the widefield surface plasmon microscope.
… significant evidence that interactions with extracellular matrix molecules also influence cell behaviour. This study aimed at determining the role of the TGF-¿s, Collagen type I, Fibronectin and Laminin in bone cell behaviour. To do this MG63 bone cells were used to examine cell adhesion and …
-
Light-triggered release of bioactive compounds from HA/PLL multilayer films for stimulation of cells
… be engineered to act as mimics of the natural cellular microenvironment. Thus, due to the myriad possibilities such as controlled cellular adhesion and drug delivery offered by LbL films, it becomes easily achievable to direct the fate of cells by growing them on the films. The aim of this work …
-
Chemical Tagging of Surface Composition Gradients With Polystyrene Nanospheres and the Extracellular Matrix Protein Fibronectin for the Study of Cellular Migration
… show great promise as tools in understanding cellular adhesion and motility. Gradients in surface electrochemical potential were prepared by poising two ends of a thin Au film at different potentials relative to a common solution Ag/AgCl reference couple, resulting in a linear surface …
-
Global Gene Expression Profiles and Proteomic Assessments in Adult Females with Obstructive Sleep Apnea Syndrome
… The laminin enzyme immunoassay (EIA), and cellular adhesion assays were performed to determine if genomic changes resulted in proteomic and phenotypic assessments. Results: OSAS subjects had nine aberrantly regulated genes, of which three genes (LAMC-1, CDC42, and TACSTD2) showed a pattern …
-
Three-Dimensional Biomimetic Patterning to Guide Cellular Migration and Organization
… spatial and biochemical control of engineered cellular architectures, such as the microvasculature. Intricate tools that allow for the three dimensional (3D) manipulation of biomaterial microenvironments will be critical for organizing cellular behavior, directing tissue formation, and …
-
Designing Scaffolds for Directed Cell Response in Tissue Engineering Scaffolds Fabricated by Vat Photopolymerization
… materials with low cytotoxicity that encourage cellular adhesion. In addition, these resins are not readily available and must be synthesized. A novel resin based on 2-acrylamido-2-methyl-1-propanesulfonic acid (NaAMPS) and poly(ethylene glycol) diacrylate (PEGDA) was formulated and printed …
-
Characterization of Meta-Keratin Biomaterials Derived from Human Hair: Applications for Fiber Development
… biocompatibility and ability to regulate cellular behavior. The main objective of this dissertation work was to test the effect of increased surface area on the biological characteristics of human hair-derived keratin biomaterials. Since the bioactivity of keratin materials is believed to …
-
Fabrication, Characterization and Cellular Interactions of Keratin Nanomaterial Coatings for Implantable Percutaneous Prosthetics
… has been used in other studies for its cell adhesion and differentiation properties, and it has been suggested that the Leu-Asp-Val (LDV) amino acid motif is the primary site responsible for cellular attachment. In the present work, keratins extracted from human hair fibers and recombinant …
-
Biomolecularly and mechanically instructive materials for guiding cell-substrate interactions
… cues. First, we generated gradients of cellular adhesion molecules that allowed us to understand the mechanism by which bromelain affects cell rolling during the early steps of inflammation. The latter part of this work utilized BP-mediated immobilization on two substrates, …
-
The Role of the ITAM-containing CEACAM3 Receptor in the Neutrophil Response to Infection by Neisseria gonorrhoeae
… of the human carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family. One of these CEACAMs, CEACAM3 (CD66d), is unique in its restriction to neutrophils and its expression of a cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM; YxxL/Ix6-8YxxL/I). In the course …
-
Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
… A low level of oncogenic Ras signaling induced cellular hyperproliferation, whereas a high level of signaling induced cellular senescence. A growing body of literature links loss of p38 mitogen-activated protein kinase (MAPK) activity with the promotion of Ras-induced transformation in murine …
-
Characterization of cofilin and its potential role in the EphA4 pathway
… receptor tyrosine kinase that is responsible for cellular adhesion and locomotion using repulsion signaling in early development of <em>Xenopus laevis</em>. EphA4 regulates cellular locomotion by controlling proteins within its signal transduction pathway, which may include the protein cofilin. …
-
Nonlinear Nonlocal Parabolic-Hyperbolic Coupled Systems for Cancer Cell Movement and Aggregation
Cells adhere to each other and to the extracellular matrix (ECM) through protein molecules on the surface of the cells. The breaking and forming of adhesive bonds, a process critical in cancer invasion and metastasis, can be influenced by the mutation of cancer cells. Several molecules have been …
-
Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
… microvascular endothelial cells (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which collectively contribute to maintaining proper BBB function. While previous studies have provided some insights into the role of the BBB in …
Page 1 of 3