Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"cells (biology)"”.
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
<p>Natural Killer (NK) cells are cells of the innate immune system that act as first line of defense against viral infections and participate in tumor immune surveillance. NK cells do not cause graft versus host disease (GvHD), or require prior antigen exposure to exert anti-tumor activity, hence …
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Human common fragile sites, identification, and analysis of breaks using <i>saccharomyces cerevisiae</i>
… stress, are frequently altered in tumor cells. Two hypotheses have been proposed to explain why common fragile sites break: (1)AT-rich segments with high flexibility in the fragile site fold into secondary structures, leading to replication fork stalling and chromosomal breakage, and (2) …
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The Role of RNA Helicase RHAU in Immunoglobulin Class Switch Recombination
<p>B cells alter the expression of immunoglobulin isotypes through a process known as class switch recombination (CSR). In these cells, activation induced cytidine deaminase (AID) binds Gquadruplex (G4) switch transcripts, which serve as guide RNAs to target AID to the immunoglobulin heavy chain …
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Estrogen's Effects on Oxidative Stress Levels in Glial Cells
… the oxidative stress level ofN1 1321 glial cells that were exposed to 600pM hydrogen peroxide. The astrocytes were pretreated for one hour with one of four types of estrogen at four concentrations ranging from 10nM - 10 uM. Two endogenous human estrogens, 17 alpha-estradiol and 17 …
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Characterization of ABF-1 in C. elegans and regulation of cellular growth and ID3 by human ABF-1
… that is expressed predominantly in activated B cells and EBV immortalized cell lines. A portion of this study sought to characterize the homolog of ABF- l in Caenorhabditis e/egans. The nematode gene product, ceABF -1, is capable of forming heterodimers with E2A gene products and binding E box …
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cAMP and Calcium Interactions in Endocrine Cells
… influx of Ca<sup>2+</sup>, in both MMQ pituitary cells and α-Pancreatic cells. The specific targets for PDEs and the domains of PDEs are still unknown. Pituitary MMQ cells were used as a model to test modulation of calcium influx through the L-type calcium channel with PDE inhibitors. cAMP analogs …
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Med12 Is A Critical Regulator of Neural Crest Lineage and Nervous System Myelination
… targets of Med12, with a special emphasis on cells of neural crest origin. Moreover, our models constitute versatile <em>in vivo</em> tools for future studies by reliably modeling a variety of pathologies presented in multiple neurological syndromes, including but not limited to developmental …
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Investigating The Effects of Silencing Epha2 In Metastatic Breast Cancer Cells
… and experimental metastasis of breast cancer cells. Current work is being done to investigate the mechanism behind EphA2’s participation in some of these processes. These studies are important because they have contributed to understanding the role that EphA2 plays in the progression of breast …
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Human Salivary Gland Stem/Progenitor Cells for Tissue Engineering, SARS-CoV-2 Susceptibility, and Neurointegration
… derived salivary gland stem progenitor cells (hS/PCs) along with those isolated from major glands to understand salivary gland susceptibility to SARS-CoV-2, while also contributing data on mechanisms that might explain the ability of coronaviruses to infect salivary glands in the absence …
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Chemical Induced Hypoxia Differentially Affects Gene Expression in Human Neuronal Cells
… human neuronal cell viability, but some cells still survived. These surviving neurons showed no morphological changes when compared to the non-treated group. However, the alteration of several intracellular events were detected, such as an increase of hypoxia inducible factor 1 (HIF-1) …
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Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell and Gene Therapy
… results in the acquisition of cancer stem-like cells (CSCs) traits in liver derived cell lines. These traits include enhanced expression of putative stem cell markers DCAMKL-1, Lgr5, CD133 and c-Myc. We also showed that HCV replication is severely impaired by siRNA-led depletion of the …
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An Exploratory Study of the Effects of BIS-Substituted Triazolium Bromide Salts on the Proliferation of WI-38 Lung Cells and H-1299 Lung Cancer Cells
… triazole (T3 5-5), on normal lung cells (WI-38), and lung cancer cells (NCI-H1299). This research investigated the biological effects of these salts on the proliferation of both normal (WI- 38) and cancerous (NCI-H1299) lung cells. Both cells were grown to 80% confluency and plated …