Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cell-substrate adhesion"”.
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First evidence of skelemin, a myosin-associated protein, in smooth muscle and its involvement in cell adhesion, and, The role of the cell cycle in cell type choice during mammalian development
… underexpression was seen to cause loss of cell-cell as well as cell-substrate adhesion. Time lapse video microscopy was used to analyze the role of the cell cycle in cell type choice during mammalian development. Discussed are methods employed to improve resolution for accurate analysis.
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Investigating The Relationship Between Surface Topology And Functional Characteristics For Injection Moulded Thermoplastic Components
… ridges perform better to reduce bacteria cell-substrate adhesion, when compared to flat surfaces, or surfaces containing dual structures (anti-fouling ridges combined with anti-wear walls). It was therefore demonstrated that nanotextured polymeric surfaces with hydrophobic characteristics …
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Delivery of hiPSC Derived Cardiomyocytes via an Injectable Nanofibrous Gelatin Polyurethane Composite Scaffold for Heart Tissue Repair
Cardiac cell therapy, utilizing contractile human pluripotent stem cell-derived cardiomyocytes, including embryonic stem cell-derived (hESC-CM) and induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), has shown promising results in treating ischemic cardiomyopathy and heart failure. …
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Effect of Cell-Substrate Interactions on Epithelial Cell Mechanics
Cell-substrate interactions play a key role in the regulation of epithelial cell mechanics. Through a series of studies, we demonstrate how substrate interactions impact both the response to an oncogene and the cellular contractility and organization of a monolayer. We first examine the effects of …
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Developing Label-free Imaging Techniques to Study Biological and Energy Conversion Processes
… cycling performance improvement of the battery cell. This thesis demonstrates a new characterization technique based on a principle that is completely different from the conventional EC detection technologies, plasmonic-based electrochemical imaging (PECI). It images local reactions (both …
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Mathematical modelling of growth factor induced cell migration in 3D engineered matrices
Cells mechanically interact with their environment to sense, for example, topography, elasticity, mechanical cues from other cells, and chemical signals. Multi-signalling stimuli have profound effects on cellular behaviour, including migration. The current study aims to develop a mathematical model …
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Identification of Cell Biomechanical Signatures Using Three Dimensional Isotropic Microstructures
… biology (BioMEMS) enables precise control of the cellular microenvironments and offers high throughput systems. The focus of this research was to develop three dimensional (3-D) isotropic microstructures for comprehensive analysis on cell-substrate interactions. The aim was to investigate whether …
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Surface engineering, characterisation and applications of synthetic polymers for tissue engineering and regenerative medicine. Investigation of the response of MG63 osteosarcoma cell line to modified surface topographies, mechanical properties and cell-surface interactions using different synthetic polymers fabricated in house with various topographical features
… is to accelerate the onset and rate of early cellular adhesion and bone growth through nanoscale surface topography at the implant surface. The main aim of this research project was to investigate cellular response to altered physical and mechanical characteristics of materials suitable for …
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Chemotaxis, shape and adhesion dynamics of amoeboid cells studied by impedance fluctuations in open and confined spaces
Die vorliegende Arbeit befasst sich mit elektrischen Impedanzmessungen von ameoboiden Zellen auf Mikroelektroden. Der Modellorganismus Dictyostelium discoideum zeigt unter der Bedingung des Nahrungsentzugs einen Übergang zum kollektiven Verhalten, bei dem sich chemotaktische Zellen zu einem …