Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cell-selective"”.
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Cell-selective modulation of the neuromuscular system in Drosophila
The capacity for all living cells to sense and interact with their environment is a necessity for life. In highly evolved, eukaryotic species, like humans, signalling mechanisms are necessary to regulate the function and survival of all cells in the organism. Synchronizing systemic signalling …
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Engineering bacteriophage nanocarriers for targeted delivery of protein reagents to prostate cancer cells
… of most proteins greatly inhibits their intracellular delivery to diseased cells, limiting targets to those displayed on the cell surface. In response to this challenge, we have developed a bacteriophage nanocarrier to deliver large payloads of proteinaceous cargo to the interior of prostate …
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Chemical Reporters for Bacterial Pathogenesis and Beyond
… amino acid chemical reporters that allow the cell-selective labeling of bacterial proteomes to facilitate the analysis of bacterial protein expression during infection of host cells. These reporters are based on unnatural amino acids that are incorporated into the bacterial proteome instead of …
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Th17 Cell Pathogenicity Promoted by Integrin α3 During Autoimmune Neuroinflammation
… is affected by chronic inflammation, and Th17 cells are critical mediators of disease pathogenesis. While targeting leukocyte trafficking is effective in treating autoimmunity, there are currently no therapeutic interventions that specifically block encephalitogenic Th17 cell migration. Here, …
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Identification and characterization of rickettsial proteins at the host-pathogen interface
Bacterial pathogens subvert host cell processes during infection by secreting protein effectors that manipulate host machinery. Cataloging such effectors has enabled a deeper exploration of the molecular basis of disease for numerous pathogens. Members of the Rickettsia genus are obligate …
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Regulatory variation and human disease
… pedigree as well as 19 diverse human cell types. We identified hundreds of genetic variants with reproducible quantitative effects on CTCF occupancy (both positive and negative). While these effects paralleled protein-DNA recognition energetics when averaged, they were extensively …
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The Development of Sulfatase-Cleavable Linkers for Antibody-Drug Conjugates
… 1,6-elimination of a payload within the target cell (Figure 1A). Initially, a panel of model linkers were synthesised using a neopentyl sulfate protecting group. Upon analysis under physiological conditions, the linkers were revealed to be remarkably stable in human and mouse plasma, but cleaved …
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Gold Nanoparticles as a Delivery System of Oligonucleotides into the Brain
… relatively low cytotoxicity and can enter cells by both active and passive uptake mechanisms and can cross the blood-brain barrier in vivo and in vitro. The aim of this study was to investigate the potential of 5nm gold glyconanoparticles as a delivery system for oligonucleotides into the …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… does it change glucose uptake into primary beta cells. VitD does however increase glucose-stimulated calcium uptake, suggesting that VitD affects transcription of genes involved in calcium flux into the beta cell. To identify molecular mechanisms linking VDR activity to increased insulin …
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Dynamic supramolecular hydrogels with adaptive biological functionality
… adaptive materials. In nature, the extracellular matrix (ECM) - the complex yet dynamic environment surrounding cells, provides cell support and ultimately determines cell fate. Cell behaviour depends on three main ECM properties; (i) its biochemistry presented by the chemical …
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In vitro selection of DNAzymes selective for monovalent metal ions and their development as sensors in living cells and organisms
… in metal ion sensing. To obtain such ion selective DNAzymes, in vitro selection methodology is exclusively used, and has resulted in a spectrum of RNA-cleaving DNAzymes selective for different types of metal ions, which have been leveraged for the development of environmental or live cell …