Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"cell-permeable peptide"”.
-
Bioengineering of a TAT-conjugated Peptide to Modulate the Activity of Glycogen Synthase Kinase-3 in Adult and Embryonic Stem Cells
The intracellular delivery of molecules to modulate signaling pathways and gene expression is a powerful approach to control stem cell fate decision. For applications in gene therapy and regenerative medicine, the use of genetic material and viral vectors raise concerns because stem cells persist …
-
Novel peptide-based approaches to study the activity and substrate specificity of protein kinases
… modulate the structure and activity of many cellular proteins, providing exquisite regulation of many physiological processes. In fact, phosphorylation/dephosphorylation is the predominant mechanism via which cellular proteins are regulated, with the activities of about 30% of all proteins …
-
Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… the only curative treatment. Hepatic stellate cells (HSCs) play a central role during liver injury and regeneration, driving matrix remodelling and impacting proliferation and differentiation of other hepatic cell types2,3. Traditionally HSCs were considered a homogenous population, with global …
-
The role of sphingosine kinases and SKAM1 in cutaneous wound healing
… (S1P). SKs and S1P regulate a diverse range of cellular processes, including cell proliferation, survival, differentiation, migration, smooth muscle cell contraction, inflammation, cytoskeleton reorganisation and angiogenesis, mainly via the engagement of S1P to a family of five S1P-specific G …
-
CYCLIZATION-BASED SITE-SELECTIVE N-TERMINAL CYSTEINE CONJUGATION, PEPTIDE STAPLING AND HISTONE DEACETYLASE (HDAC) PROBING
… modify N-terminal cysteines of unprotected peptides or proteins in a single step. We showed that α-fluoroketone molecules afford the cyclization reaction with the beta amino thiol group of N-terminal cysteine. Both chemo and stereo-selectivity of this reaction have been studied using 2D NMR …