Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 330 for “"cell-mediated"”.
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T cell mediated combination immunotherapy
… cytokine support, and comprehensive adoptive T cell transfer make up the broad field of immunotherapeutics. Due to the naturally complex interactions inherent in the immune system, there are many options for therapeutic intervention, however, this same complexity makes it extremely difficult to …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… is characterized by the breakdown of B cell immune tolerance to self-antigens and consequent production of pathogenic autoantibodies. Plasmacytoid dendritic cells (pDCs), a potent type I interferon (IFN-I) producer, have been linked to the pathogenesis of systemic lupus erythematosus …
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Nonspecific Cell-Mediated Cytotoxicity in the Cat
… assay, naturally occurring cytotoxic cells were demonstrated in peripheral blood and spleens of domestic cats. Lymphocytes from blood and spleen were purified over Ficoll-Hypaque and added to uninfected, vaccinia-infected, or herpes-infected adherent feline origin target cells and to a …
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Quantifying T cell Mediated Killing for Melanoma Immunotherapy
Adoptive cell therapy (ACT), based on the adoptive transfer of tumor-infiltrating lymphocytes (TILs) has well-recognized advantages such as (1) high specificity for target cells; (2) the ability to target even micrometastases; (3) the potential to proliferate in vivo within the host thus increasing …
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Sphingosine-1-phosphate in mast cell-mediated allergic responses
Mast cells play a critical role in both acute and chronic inflammation and mature in peripheral tissues from bone marrow-derived progenitors that circulate in the blood as immature precursors. Mast cell progenitors are likely to encounter the serum-borne bioactive sphingolipid metabolite, …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… genetic and other factors. T helper 17 (Th17) cells play a critical role in the immune pathology. Th17 cells are a group of specialized CD4+ T cells with potential pro-inflammatory function which are different from other T cells such as T helper 1 (Th1) cells or T helper 2 (Th2) cells. Th17 …
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Bioactivity and Cell-Mediated Targeting of Multistage Nanoporous Silicon Particles
… on the natural tumor tropism of mesenchymal stem cells (MSC) to achieve dynamic targeting were investigated. Briefly, successful modulation of the release kinetics was achieved by adjusting the pore size of NSP regulated by the degree of penetration. In addition, by adjusting the pore size the …
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MRGPRX2 Signaling on Mast Cell-Mediated Pseudoallergy and Neuroimmune Interaction
… to high affinity IgE receptor, human mast cells (MCs) express a newly identified receptor known as Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse ortholog MrgprB2). This receptor is predominantly expressed on only one subtype of MCs and it can be activated by a diverse group of …
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Cell-Mediated Cytotoxicity of Jensen Tumor in Sprague-Dawley Rats
<p>An in vitro system for the study of the cell-mediated immune response to Jensen Sarcoma (JS) is described. The tumor grew unrestricted and lead to the demise of 80% of successfully challenged Sprague-Dawley rats (persistors) while 20% of challenged rats (regressors) destroyed the tumor by an …
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Cell-mediated contraction & induced regeneration of the injured peripheral nerve
Cell-mediated mechanical forces drive closure of severe wounds in adult mammalian organs, including the sciatic nerve following neurotmesis. Without experimental intervention the defect closes rapidly via contraction of transected nerve stumps by a thick, cohesive capsule of myofibroblasts (MFB) …
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Humoral and cell-mediated immunity in vitamin A-deficient lambs
Antigen-specific and polyclonal serum immunoglobulin G (IgG) concentrations were measured in control (Con), vitamin A-deficient (A-def), and vitamin A-repleted (A-rep) lambs. In Trial, I ewe lambs were injected with primary and secondary antigenic challenges of ovalbumin (1mg) and lysozyme (.1mg). …
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Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries
… excessive pulmonary inflammation in myeloid cells using a mouse model of sepsis-associated ALI. In the first approach we screened for microRNAs during the recovery phase of ALI that could potentially regulate inflammation. We found that miR-147 is highly expressed during the recovery phase of …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
… of neurons with targets. Olfactory ensheathing cells (OECs), a specialized glial cell, may contribute to olfactory repair, and have been used to promote recovery from spinal cord injury. However, there mechanisms underlying OEC-induced regeneration are poorly appreciated. To understand these …
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Can levamisole upregulate the equine cell mediated immune response in vitro?
… horses have decreased immune response. A cell-mediated immune response has been shown to be protective for development of EPM after infection with Sarcocystis neurona in mouse models. Levamisole has been proposed as an adjunctive therapy for EPM to upregulate the cell-mediated immune …
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Functional analysis of TL1A/DR3 interactions during T cell-mediated immune responses
… understanding of its structure and the role in T cell-mediated immune responses is currently incomplete. DR3 expression is strongly up-regulated on activated T cells, although it also is present on resting CD4+ T cells, while the expression of TL1A is rapidly and transiently upregulated on …
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