Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"cell-intrinsic immunity"”.
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Evolution of antiviral breadth in Mx GTPases
… viral pathogens coopt host resources and subvert cellular processes to promote their own replication. In response, host organisms have evolved numerous countermeasures to thwart viral infection. However, the molecular basis for how host antiviral defenses overcome the daunting challenge of viral …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… of host defense against infection. Activation of cell-intrinsic immunity and optimal priming of adaptive immunity against West Nile virus (WNV), an emerging vector-borne virus, depends on recognition by RIG-I and MDA5, cytosolic pattern recognition receptors (PRRs) of the RIG-I-like receptor (RLR) …
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Identification of an Interferon Signaling Pathway Linking Membrane Cholesterol Accessibility to Host Defense Against Pathogens
… mechanisms by which specific γ-ISGs confer cell-intrinsic immunity against bacterial pathogens. Unexpectedly, I found that IFN-γ-activated macrophages secreted a soluble product that potently inhibited infection of the Gram-positive intracellular pathogen Listeria monocytogenes. To identify …
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Elucidating the Role of Phospholipid Scramblase 1 in Antiviral Innate Immunity
… against infection. This baseline resistance, or intrinsic immunity, is the first layer of cellular defense that a virus must evade or antagonize in order to infect a cell. Intrinsic immunity also forms an important barrier against zoonosis—the transmission of a virus to new species outside its …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… to cause neurodevelopmental complications. Cell-intrinsic immune responses are the first line of defence against viruses, mediated by constitutively expressed host proteins and processes that respond directly to virus infection. As a result of virus-host coevolution, viruses often antagonise …