Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cell-fate choice"”.
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The physics of cell-fate choice
Multicellular organisms are composed of many different cell types. All such cells arise from a single cell--- the zygote--- and acquire the various cell fates seen in adult organisms. The different cell types are characterized by distinct, cell-fate-specific gene expression patterns. Cells of …
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Dynamics of Cell Fate Decision Making Between Sporulation and Competence in Bacillus Subtilis
During multipotent differentiation cells must reliably make a cell fate decision under a variety of conditions, yet remain sensitive to changes in extracellular environment. It is unclear how the cells reconcile these seemingly contradictory requirements. To complicate the issue, the cells often …
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Uncovering molecular mechanisms of the notch signaling pathway in the regulation of pituitary gland development
… the release of hormones from distinct endocrine cell types within the gland. During development, the endocrine cell types are derived from a common pituitary progenitor cell. To maintain the correct number of each cell type, it is essential that the pituitary coordinate progenitor maintenance and …
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The effect of aging on myelinating gene expression and oligodendrocyte cell densities
… changes (i.e., 2-16 months of age) in glial cell response during the recruitment (i.e., demyelination) and differentiation (i.e., remyelination) phases of myelin repair. I found that the time between 12 and 16 months of age is a critical period during which there is an age-related decrease in …
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Novel roles of KAT2A chromatin complexes ATAC and SAGA in normal and malignant haematopoiesis
… dynamic process by which the full array of blood cell types originates from multipotent haematopoietic stem cells (HSCs). The blood system has long been an attractive model to explore how cell fate decisions are conducted at the molecular level, to generate the vast diversity of blood cell types. …
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The role of the mechanical microenvironment in regulation of cholangiocyte specification and tubulogenesis
… evidence highlights the influence of the extracellular matrix (ECM) on cell fate and functionality associated with ageing, development and disease (Segel et al. 2019; Bansaccal et al. 2023). Despite most studies emphasising ECM stiffness, recent insights suggest a cooperative role of ECM ligand …
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Mechanical mapping of lineage boundaries in the developing Xenopus laevis embryo
Stem cells are capable of both self-renewal and differentiation into a range of other cell types and must regularly make decisions between these fates. While we have a good understanding of how the chemical environment influences these decisions, there is mounting evidence that stem cells integrate …
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Translational control mechanisms in the p53 response network
… factor p53 is considered a master gene of cellular responses to homeostasis changes. It is also a prominent tumor suppressor gene with the title of “guardian of the genome”. The increasing number of transcriptome analyses in cell lines treated with different agents activating p53, continues …