Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cell-cell signalling"”.
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Engineering LuxR-type quorum sensing proteins for new functions
… actuating downstream gene expression based on cell-cell signalling. Cell-cell signalling allows for complex and multi-cellular behavior otherwise impossible with unicellular logic. However, building complex cell-cell signalling genetic circuits is currently challenged by a lack of tools for the …
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Studying the direct effects of forces on embryonic stem cell behaviour
Cells experience different mechanical cues from their local environment, including shear flow, forces applied by neighbouring cells, and substrate stiffness. These external signals influence cell behaviour, also in embryonic stem (ES) cells, where they could potentially affect pluripotency or …
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Investigations into altered cellular glycosylation associated with metastatic competence in breast cancer cell lines
… in breast and other cancers. Three breast cancer cell lines characterised to stably synthesise an array of GalNAc-glycans were employed in the work reported here (MCF7, ZR751 and BT474). HPA lectin labelling and quantification were optimised and it revealed a more complex HPA-binding profile than …
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The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
Cell competition is a form of cell-cell signalling that results in the elimination of less fit cells from a tissue by their fitter counterparts. I take advantage of an established in vitro model of cell competition using Madin-Darby canine kidney (MDCK) cells to shed insight into the molecular …
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CsgA, a putative signal molecule of the myxobacterium Stigmatella aurantiaca involved in fruiting : characterization of the csgA gene and influence of csgA inactivation on development
Cell-cell interaction is a prerequisite for multi-cellular development and cellular differentiation of the Gram-negative bacterium Stigmatella aurantiaca. For the elucidation of the temporal and spatial coordination of the physiology and motility of the cells during development, isolation and …
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Investigating Wnt3-mediated symmetry breaking and cell fate in engineered gastruloids
… 2005). In contrast, aggregates of embryonic stem cells (ESCs) termed gastruloids are able to display symmetry breaking and develop an AP axis in the absence of extraembryonic tissues or localised exogenous positional signalling (Baillie-Johnson, van den Brink, Balayo, Turner, & Arias, 2015; …