Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"cell-cell interactions"”.
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Probing the role of cell-cell interactions in hepatic ensembles
… is scarce. Alternatives such as engineered cell-based therapies aim to restore tissue-specific functions of solid organs, but leave much to be desired. Key challenges hindering the translation of cell-based therapies relate to (1) cell sourcing, (2) graft scale-up, and (3) vascularization, …
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Controlling cell-cell interactions in hepatic tissue engineering using microfabrication
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1997.
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Analysis of Cell-Cell Interactions in the Formation of Drosophila Antennal Lobes
… Drosophila brain extends our knowledge of their cellular functions and helps to shed light on the pathology of human genetic diseases.
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The Roles of daf-6 and Cell-Cell Interactions in Sensory Organ Morphogenesis
<p>The development of multicellular organs depends on the regulation of cell shape, position, and orientation. The genetic regulation of these morphogenetic processes is poorly understood. As a model for organ morphogenesis, I studied the development of the Caenorhabditis elegans amphid sensory …
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Homeostatic mechanics for a synthetic cell: predictions on substrate anisotropies and cell-cell interactions
… one or more biological processes, which in cells are known to be highly coupled. This added complexity limits the control over the biocompatibility and biofunctionality of the designed tissues. Amongst the many degrees of freedom in question, substrate topological and mechanical properties, …
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Agent-based modelling of cell-cell interactions for in vitro vascular formation and cancer cell growth
… an emergent pattern in interacting endothelial cells. A cancer tumour is a different but related complex system that contains various types of cells, some of which having cancer-inducing mutations. To understand the formation of a vascular structure or a cancer tumour, it is important to …
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Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
<p>Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with numerous cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with associated changes in NP cell phenotype, …
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Engineering the tumor microenvironment using microfluidics : effects of cell-cell interactions and endothelial barrier function on tumor cell intravasation
… there is a need for a better understanding of cell-microenvironment interactions to identify new therapeutic targets. A key step during cancer metastasis is cancer cell intravasation (entry of cancer cells into the blood vessels) that results in tumor cell dissemination into distant organs. …
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Cell culture platforms with cell-cell adhesive ligands for biomedical applications
Cell behavior is regulated by a number of different mechanical and chemical cues within the extracellular microenvironment, including the surrounding matrix and neighboring cells. Although biomaterials have been engineered to present several adhesion molecules that mimic cell-extracellular matrix …
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Soluble factors and remodeling in a synthetic stem cell niche
Hematopoietic stem cells produce the body’s entire complement of blood and immune cells, in a process known as hematopoiesis. Producing half a trillion cells daily, this rare population (<0.01% of human bone marrow) possess the ability to produce multiple cell lines (differentiation) and stem cell …
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An individual-based GPU simulation framework for collective bacterial dynamics in swarms and biofilms
… of complex bacterial communities at single-cell resolution are now possible. Guided by these rich experimental data sets, we develop minimal individual-based models to uncover the governing forces driving the dynamics in microbial systems. Our model incorporates the biophysical processes of …
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Computational Modeling of Bacterial Biofilms
… of complex bacterial communities at single-cell resolution are now possible to obtain. Guided by these rich experimental data sets, we improve a recently proposed three-dimensional individual-based simulation framework to uncover governing microscopic dynamics at single-cell level that drive …
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Statistical Methods for the Analysis of Contextual Gene Expression Data
… and most recently at the level of single cells. Increasingly these technologies also preserve context information, such as assaying tissues with high spatial resolution. A second example of contextual information is multi-omics protocols, for example to assay gene expression and DNA …
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… of PAFs. Morevoer, it is likely that cell-cell interactions between hypoxia-stimulated PAFs and other vascular cells – particularly smooth muscle cells - initiates and progresses the changes that occur in pulmonary vascular remodelling in the other vessel compartments. Although hypoxic …
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Investigating Cellular and Molecular Mechanisms of Neuronal Layering in Self-Organising Aggregates of Zebrafish Retinal Cells
… organised into distinct layers: Retinal Ganglion Cell (RGC), Amacrine Cell (AC), Bipolar Cell (BP), Horizontal Cell (HC) and Photoreceptor cell (PR) layers. This remarkable organisation is evolutionarily conserved in vertebrates, yet little is known about the mechanisms by which these cells form …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… as well as fundamental investigations into stem cell behavior and cell-cell interactions. Tissue engineering is also increasingly used for regenerative medicine and for modeling of metabolism and physiology. However, there are material challenges associated with cellular organization, tissue …
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Microengineered responsive platforms for spatial and geometrical control of multicellular organizations
Living systems are composed of complex multicellular organizations containing various cell types spatially distributed in defined microenvironments. The intricate cell-cell and cell-matrix interactions in these microenvironments regulate the cell fate, differentiation of the cells, and functions of …
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Fundamental representations of regions and interactions in spatial transcriptomics
While cells are often considered the fundamental unit of biology, it is their spatial coordination that gives rise to the tissue architectures underlying both health and disease. Spatial transcriptomics technologies offer a unique window into this coordination by simultaneously capturing the …
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Engineering of tools for De Novo Assembly of Human Cells
… provide spatial control by patterning cell types with high resolution, but face challenges in reproducing physiologically accurate cell types and interactions. Bottom-up methods, such as organoids, induce pluripotent cells to differentiate into aggregates that resemble their in vivo …
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