Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"cell-cell fusion"”.
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Contribution of the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein to Host Cell Entry and Membrane Fusion
… to its simple genetic organization, broad host cell tropism, and ability to be easily grown in cell culture. Therefore, VSV has been used as the prototype to study viral entry, transcription, replication, and assembly. Viral entry, a critical step in the lifecycle of the virus, is mediated by …
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OVERT AND LATENT PATHWAYS OF POLARITY SPECIFICATION IN ZYGOTES: THE HAPLOID-TO-DIPLOID TRANSITION
… normal differentiation and function of diverse cell types, from unicellular prokaryotes to multicellular eukaryotes. Polarity specification, the establishment of an axis for directed growth and secretion, allows cells to achieve anasymmetrical state. This phenomenon is conveniently exemplified …
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Multinuclear and Mononuclear Polyploidy in the Drosophila Hindgut and Heart
… organized. Tissues can be composed of many small cells or comparatively fewer large cells that add nuclear content to facilitate tissue growth. The cells can be separate, discrete units or interconnected collectives. The nuclear composition of a tissue has functional consequences from the tissue …
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Interazioni tra le glicoproteine D, B, H ed L critiche per la fusione indotta dal virus Herpes simplex
… for herpes simplex virus (HSV) entry into the cell and for cell-cell fusion in transfected cells. gD serves as the receptor-binding glycoprotein and as the trigger of fusion; the other three glycoproteins execute fusion between the viral envelope and the plasma or endocytic membranes. Little is …
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Regulation of C-type lectin-like receptors dectin-1 and CLEC-2 by tetraspanins
… in a range of biological processes including cell signalling, adhesion, intracellular trafficking, cell-cell fusion and viral entry. The tetraspanin CD37 was recently shown to negatively regulate the C-type lectin-like receptor dectin-1, which is essential for innate immune responses to fungal …
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The Protein Composition of the Chlamydomonas Flagellar Membrane Is Dynamically Regulated by Cilium-Generated Signaling During Fertilization
The cellular and molecular mechanisms specifying the membrane protein composition of cilia and flagella at steady state and during cilium-generated signaling are poorly understood. Our laboratory uses the biflagellated green alga Chlamydomonas as a model system to study regulated movement of the …
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Manipulation of the Moloney Murine Leukemia Virus Envelope Protein in an Effort to Develop Directly and Indirectly Targeted Retroviral Vectors for Use in Human Gene Therapy
… targeted, and tailored vehicle aimed at cancer cells lends itself to the use of replication deficient retroviral gene therapy vectors with interchangeable receptor binding sites. These vectors may be used separately or in combination with each other to ensure maximum delivery of a suicide gene …
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Effects of galectins and antibodies in HIV infection; Novel Assays
… neutralization and inhibition of virus induced cell-cell fusion. In a multicenter study, Neutnet II, the assay compared well with other neutralization assays and was suggested to be an alternative to the traditional peripheral blood monocyte (PBMC)-based assay and the TZMbl assay. The glycans of …
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Investigating the Molecular Mechanisms of TMEM16F – a Ca2+ Activated Phospholipid Scramblase and Ion Channel
… as blood coagulation, ataxia, muscle dystrophy, cell-cell fusion and viral infection.To further understand their biology and design therapeutics to treat the related diseases, it is urgent to unveil the structures, machineries as well as pharmacological profiles of the multifunctional TMEM16 …
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Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness
HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination. This thesis characterises neutralizing response in two cohorts in Africa, and in a detailed study of one individual, elucidates the …
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Muscle-derived cytokines: novel regulators of skeletal myogenesis
… part to the resident population of muscle stem cells in the tissue, known as satellite cells. These adult stem cells reside in a quiescent state near the basal lamina of skeletal myofibers, but are rapidly activated by myofiber injury from trauma, strenuous exercise, or disease. Upon activation, …
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Entwicklung und Evaluation von IgY-Antikörpern gegen die Metalloproteinase ADAM12
… tail”. ADAM12 mainly functions as a mediator of cell to cell contact, such as cell adhaesion, cell cell fusion and cell invasion. ADAM12 is a catalytically active protease and has a proven role during myoblast fusion and in the formation of osteoclasts. ADAM12 has also been found in …
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Die Rolle des CD9 bei der CDV-Infektion
… ist abhängig von der Fähigkeit des Virus, die Fusion von Membranen zu induzieren und somit die natürliche Barriere zwischen einzelnen Zellen zu überwinden. Neben den viralen Glykoproteinen sind dabei Proteine in der Membran der Wirtszelle ausschlaggebend für einen erfolgreichen Ablauf dieser …