Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"cell-autonomous"”.
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ENDOCYTIC CONTROL OF CELL-AUTONOMOUS AND NON-CELL-AUTONOMOUS FUNCTIONS OF P53
… recognized for its role in determining cell fate decisions through inhibition of NOTCH signaling, a process achieved via endocytic trafficking. Subsequently, NUMB has emerged as a significant tumor suppressor, particularly in the context of breast cancer, where it stabilizes the critical …
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Sphingomyelin as a danger signal in cell-autonomous immunity
Individual cells employ mechanisms of cell-autonomous immunity to defend their cytosol against bacterial invasion. One such mechanism involves indirect detection of the pathogen through recognition of pathogen-induced disturbances causing the appearance of specific host molecules in an abnormal …
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
… never-ending conflict for supremacy. </p><p>Intracellular pathogenic bacteria have developed multiple ways in which to subvert the host’s cell intrinsic defense systems. One common mechanism is the establishment of a pathogen vacuole (PV) which serves as a replicative niche for growth and shields …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… or lymphatic system. The presence of tumour cells in the draining lymph node (lymph node involvement) represents the most important prognostic factor for breast cancer patients. Despite its clinical implications, the mechanisms governing lymphatic metastasis remain poorly understood. This …
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The role of cell autonomous complement in B cell function and regulation
B cells are a cornerstone of the adaptive immune response as they not only differentiate into antibody-producing plasma cells, mediating protection from pathogens, but also have several antibody-independent, immune-regulatory functions. Even with these essential roles, some aspects of their …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
… secretion system (T3SS) to manipulate the host cell and counteract anti-bacterial defense pathways. My work demonstrated that IFN-induced guanylate-binding proteins (GBPs) are novel targets for IpaH9.8. GBPs inhibit actin-dependent motility and cell-to-cell spread of bacteria unless they are …
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Genetic and molecular studies of cell-autonomous execution during programmed cell death in C. elegans
Apoptosis or programmed cell death was originally defined by evolutionarily conserved morphological characteristics that include shrinkage of cell volume and chromatin condensation. Apoptosis functions as a highly controlled mechanism for the elimination of unwanted or damaged cells and is …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… immune responses. IFN-γ is mainly secreted by T cells and natural killer (NK) cells and activates macrophages, promotes antigen presentation and enhances antiviral and antibacterial immunity. In the case of bacterial pathogens, such as S.Typhimurium, priming with IFN-γ leads to an inflammatory …
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P53 Drives A Transcriptional Program That Elicits A Non-Cell-Autonomous Response and Alters Cell State In Vivo
<p>Cell stress and DNA damage activate the tumor suppressor p53, triggering transcriptional activation of a myriad of target genes. The molecular, morphological, and physiological consequences of this activation remain poorly understood <em>in vivo</em>. We activated a p53 transcriptional program …
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Investigating the role of cell-autonomous ROS status in the regulation of hippocampal neural precursor cells in adult mice
… a continued recruitment of neural precursor cells (NPCs) into active cell cycle and their progressive transition into post-mitotic granule cells. These adult born neurons integrate into the existing circuitry and confer structural plasticity, which aids in key hippocampal functions. For …
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MOTONEURON MAINTENANCE DEFECTS AND NON-CELL AUTONOMOUS CONTRIBUTIONS BY SCHWANN CELLS IN ZEBRAFISH MUTANT AND MORPHANT MODELS FOR SPINAL MUSCULAR ATROPHY
… Studies in SMA animal models suggested a non-cell autonomous contribution of Schwann cell defects to MN degeneration. Supporting this, I found that restoration of Smn in Schwann cell precursors (SCPs) of smn morphants partially ameliorates MN defects. Transcriptome analysis of Smn deficient …
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The Role of Microglia and Astrocyte in Spinocerebellar Ataxia Type 1
… microglia as well as the previously undiscovered cell-autonomous effect of polyQ expanded ATXN1 on astrocytes. Using the Lysm-Cre Ikkβflx/tlx line to assess the role of microglial activation in the transgenic ATXN1[82Q] mouse model of SCA1, I show that inhibition of microglial reactivity does not …
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Developmental trajectory of functional neocortical networks in an in vitro mouse model of Rett syndrome
… is poorly understood. Compared to molecular or cellular studies, microscale network analysis may reveal how genetic mutations influence neuronal circuitry relevant to behaviour. Investigating how microscale functional networks are disrupted in RTT in humans remains challenging. In contrast, …
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Novel detection and evasion mechanisms pertinent to immunity against Salmonella Typhimurium
Cells defend their cytosol against pathogen invasion using cell-autonomous immunity. When pathogens enter the cytosol they can damage host endomembranes, causing the mislocalisation of host molecules not normally found in the cytosol that are sensed as Danger Associated Molecular Patterns (DAMPs). …
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Interplay between Piezo1-mediated mechanosensing and the chemical guidance cue Semaphorin3A during development of the embryonic nervous system
… to their destination. Here, retinal ganglion cells (RGCs) send their axons out of the retina, to cross with axons of the opposite eye in the optic chiasm and continue their journey through the diencephalon as an optic tract, before reaching their target, the optic tectum. During formation of …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
Cancer cells display oncogene-driven rewiring of metabolism to produce energy and macromolecules for growth. Inhibition of growth-promoting metabolic pathways may prove to be a useful therapeutic strategy in cancer. However, neither the full breadth of cancer cell metabolic diversity, nor the …
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Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells
… in hematopoiesis and hematopoietic stem cells (HSCs). In this thesis, we aim to elucidate the potential cell-autonomous and non-cell-autonomous roles of ARAP3 in hematopoiesis and HSCs using several conditional knockout (CKO) transgenic mouse models in addition to the KI/KI mutant mouse …
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Pericyte deficiencies in a foxf2 loss of function mutant
… decreased pericyte density but a combination of cell-autonomous and non-cell-autonomous effects. A downstream target of foxf2a, loxl2b, is downregulated in foxf2 mutants. While loxl2b mRNA is sufficient to boost brain pericyte numbers, mutants for this gene do not show an obvious phenotype, …
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The retinoblastoma gene family in tumor suppression and development
… embryos and adults made with marked Rb-/- cells. We demonstrated that although brains of chimeric embryos exhibited extensive ectopic S-phase entry, unlike in germline Rb-/- littermates, in these chimeras the majority of Rb-deficient cells survived and differentiated into neuronal fates. …
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Molecular Mechanisms Controlling the Development and Evolution of the Human Cerebral Cortex
… expansion. The advent of pluripotent stem cell (PSC) derived models of human and non-human primate corticogenesis has revolutionised the study of human cortical development, enabling the characterisation of cell-autonomous developmental mechanisms, comparative studies with more closely …
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