Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"cell wall synthesis"”.
-
Untersuchungen zur Biosynthese der pflanzlichen Zellwand = [Identification and characterization of genes involved in plant cell wall synthesis]
Even though the structure of the plant cell wall is by and large quite well characterized, its synthesis and regulation remains largely obscure. However, it is accepted that the building blocks of the polysaccharidic part of the plant cell wall are nucleotide sugars. Thus to gain more insight into …
-
Characterizing the role of central carbon metabolism and cell wall stress responses in Bacillus subtilis cell wall synthesis
The cell wall is an essential organelle for many bacteria since it provides mechanical strength and prevents bacterial cell lysis due to internal turgor pressure. Additionally, the cell wall is the first line of defense against various external stresses. The mesh of peptidoglycan is a major …
-
Synthesis of D-alanyl-D-alanine dipeptide isosteres and cephalosporin prodrugs
… linkages in the growing peptidoglycan cell wall. Synthesis of dipeptide isosteres which may be incorporated into the growing cell wall is described. Previously published syntheses were employed as well as a Wittig reaction using a chiral Wittig reagent, a reaction not used in the …
-
Requirements for Compartmentalization of Penicillin-Binding Proteins during Sporulation in Bacillus subtilis
… is regulated in the two differentiated cells in Bacillus subtilis, the mother cell and the forespore, by coordinated expression of different sigma factors that recognize specific promoters in each compartment. The functional and compartmental specificity of individual penicillin-binding …
-
Identifying biosynthetic pathways for mycobacterial cell wall components using transposon mutagenesis
… disease tuberculosis, has a distinct lipid-rich cell wall. Several anti-TB drugs target cell wall biosynthetic pathways. A good understanding of its biosynthesis will provide helpful clues for the development of novel drug targets. A strategy based on random transposon (Tn) mutagenesis with two …
-
Cellulose biosynthesis inhibitors modulate defense transcripts and regulate genes that are implicated in cell wall re-structuring in arabidopsis
The cell wall is a multifunctional structure which is implicated in plant growth and development as well as responding to any environmental changes including biotic and abiotic stresses. One of the practical approaches in cell wall integrity studies is the modification of the quality and quantity …
-
Functional characterization of NAC-domain transcription factors implicated in control of vascular cell differentiation in Arabidopsis and Populus
… renewable raw material. The composition of xylem cell types in wood determines the utility of different types of wood for distinct commercial applications. Using expression profiling and phylogenetic analysis, we identified many xylem-associated regulatory genes that may control the …
-
Construction of a Pseudomonas aeruginosa Dihydroorotase Mutant and the Discovery of a Novel Link between Pyrimidine Biosynthetic Intermediates and the Ability to Produce Virulence Factors
… Pyrimidines are required for RNA and DNA synthesis, as well as cell wall synthesis and the metabolism of certain carbohydrates. Recent findings, however, indicate that the pyrimidine biosynthetic pathway and its intermediates maybe more important for bacterial metabolism than originally …
-
SORTASE AND CHEMICAL BIOLOGY AS TOOLS TO STUDY UBIQUITINATION
… is implicated in a plethora of essential cellular processes including but not limited to protein homeostasis, protein trafficking, cell signaling cascades, and gene expression. Despite nearly 50 years’ worth of scientific research, many questions still surround the impacts and roles of …
-
Genome scale metabolic modelling to identify metabolic responses of resistant bacteria to antibiotic challenges
… pathway involved in lipopolysaccharide and cell wall synthesis was identified as a response to tilmicosin treatment as a resistance mechanism. The enzymes involved in this pathway could be potential helper drug targets along with macrolide treatment. In order to understand the metabolic …
-
The streptomyces cytoskeletal protein (Scy) is a key component of the tip organising centre for polarized growth in streptomyces coelicolor
… of multigenomic hyphae that then form unicellular spores. Bacterial cell shape determination has been influenced heavily by the discovery that bacteria have a number of eukaryotic cytoskeletal homologues as well as a number of accessory proteins unique to prokaryotes. As cell shape …
-
A sorghum NAC gene is associated with variation in vascular development, biomass properties, and yield potential
… blocks of the vascular system are secondary cell walls, which make up the majority of plant biomass. Understanding the gene regulatory network underlying secondary cell wall synthesis can improve the understanding of vascular development and yield and ultimately benefit future cereal …
-
The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis
… a wide range of genes involved in cell wall synthesis and metabolic functions. This regulatory function is likely to influence bacterial growth and survival. This research investigated the biochemistry and 3D structure of Lsr2 from M. tuberculosis. Transmission electron microscopy …
-
Establishment and regulation of polar growth in Streptomyces
… question in developmental biology is how cells establish polarity, and most strikingly how cells grow polarly. From neuronal dendrites and root hairs to bud emergence and elongation of yeast, broadly conserved pathways control cell polarity in eukaryotes. In contrast, virtually nothing is …
-
PopZ and FtsZ coordinate polar growth termination and cell division in Agrobacterium tumefaciens
Understanding how bacterial cells expand their cell walls is an important question with relevance to development of antibiotics. While many studies have focused on the regulation of bacterial elongation utilizing lateral cell wall biogenesis, polar growth in bacteria is less well understood. Yet, …
-
Genome-Scale Quantification of Target Vulnerability in Mycobacterium Tuberculosis
… central dogma processes, protein secretion and cell wall synthesis, including targets currently unexplored in the drug discovery pipeline. Likewise, we identify invulnerable processes that can withstand substantial inhibition with little impact on bacterial fitness, including targets of failed …
-
Functional analysis of the sucrose synthase gene family in Arabidopsis thaliana
… can play a role in supplying energy in companion cells for phloem loading (Fu and Park, 1995), provides substrates for starch synthesis (Zrenner et al., 1995), and supplies UDP-glucose for cell wall synthesis (Haigler et al., 2001). Analysis of the Arabidopsis genome identifies six Susy isoforms. …
-
The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
… with penicillin binding proteins (PBPs) disrupts cell wall synthesis and in the case of some ß-lactams, initiates the ampC induction pathway. Several factors are involved in the induction of ampC in all genera including the interaction of a ß-lactam inducer with the penicillin binding proteins, …
-
Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
… an FDA-approved anti-rheumatic drug possessed excellent antibacterial activity against <em>S. aureus</em> and was found to exert its effect by inhibiting multiple biosynthetic pathways including DNA, protein and cell wall synthesis. Furthermore, auranofin was found to be efficacious in a mouse …
-
Development and use of a synthetic biology toolkit to enhance high value lipid production in Nannochloropsis oculata
… potential to address this issue though cellular and specifically lipid metabolic engineering; however, the use of established CRIPSR systems is prohibitively expensive. This MRes thesis aimed, therefore, to develop use of BEC10, a novel CRIPSR nuclease (BRAIN-Biotech AG), to gene edit …
Page 1 of 2