Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 745 for “"cell viability"”.
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The Involvement of Progesterone in Glial Cell Viability
… the effects of ethynodiol diacetate on the viability of hydrogen peroxide stressed glial cells. We wanted to determine the extent in which varying concentration of ethynodiol diacetate affect cell viability of cultured glial cells from hydrogen peroxide toxicity. Based on previous studies, …
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Mechanisms by which hypoxia augments Leydig cell viability and differentiated cell function in vitro
… peptide in the testicular interstitial cells. Leydig cells, which comprise up to 80% of the testicular intertubular cell population, are known to synthesize testosterone in situ. Indirect evidence indicated that an oxytocin-like peptide was also present in Leydig cells. The question …
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The Mitochondrial Fusion Protein, Optic Atrophy 1 (OPA1), Alters Cellular Metabolism to Support Cancer Cell Viability
… Furthermore, profiling of OPA1-silenced cells revealed reprogramming of steady-state intracellular metabolites spanning intermediates of amino acids, TCA cycle and nucleotide biosynthetic pathways. To investigate nutrient usage, we performed stable isotope tracer analyses using [13C5]- …
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Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… mellitus (T1DM) is characterised by pancreatic β-cell demise, resulting in a requirement for permanent insulin therapy. Pro-inflammatory cytokine pathways, acting via STAT1 and STAT2, contribute to β-cell death whereas anti-inflammatory mechanisms (operating via cytokines such as Interleukin-13 …
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Exploring the effects of classical immune activation on circuit excitability and cell viability in the mouse brain
… immune activation on circuit excitability and cell viability. To initiate inflammation, I administered lipopolysaccharide (LPS), an endotoxin derived from gramnegative bacteria, and interferon-gamma (IFNy), a cytokine typically released by lymphocytes, to brain slices on varying time scales. I …
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The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines.
… modulated in many androgen sensitive tumour cell lines. Increased expression of some PKC isoforms has also been linked to immortality in many cancer cell lines. Conjugated linoleic acids(CLAs) are naturally occurring positional and geometric isomers of the fatty acid linoleic acid (LA). CLAs …
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Nanotoxicity of oxide-derived engineered nanomaterials: impact on cell viability and function, with conventional assays and evaluation of novel eicosanoid profiling
… impact of a panel of ENMs on alveolar epithelial cell function and survival, as well as to assess the potential value of an alternative method for nanotoxicological screening. Eicosanoid profiling was used to assess both toxicity and inflammatory markers associated with a panel of ENMs, this …
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Automatic Label-Free system for cell viability on-a-chip [Sistema automatico Label-Free per la determinazione della vitalità cellulare su chip]
… Nel contesto della valutazione della vitalità cellulare, gli approcci convenzionali si basano tipicamente sulla marcatura chimica, una procedura invasiva, dispendiosa in termini di tempo e limitata ad analisi di tipo endpoint, che impedisce il riutilizzo dei campioni e richiede strumentazioni …
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STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF THE PANAMANIAN GOLDEN FROG (ATELOPUS ZETEKI) SPERMATOZOA – IMPACT OF MEDIUM OSMOLALITY AND CRYOPRESERVATION ON MOTILITY AND CELL VIABILITY
… and seasonality; 2) identify the effect of extracellular conditions, mainly dilution and temperature, on motility, forward progressive motility, duration of motility, morphology and DNA integrity; and 3) evaluate the effect of cryoprotectants on motility, forward progressive motility and sperm …
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Methods of cellular integration and techniques for improving encapsulated cell viability for the purpose of developing living materials and cell based bio-sensing materials
… for detection-reporter systems based on living cells that are genetically tailored to sense target analytes with high levels of specificity and accuracy. A biotic or living material would allow the development of simple, hand held devices that could be utilized for many applications including …
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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells
… analogues can protect neuroblastoma, SH-SY5Y cells, against chemical stressors of relevance to AD and, secondly, whether these compounds alter ADAM10 maturation/activity and the proteolysis of the enzyme's substrates, APP, prion protein (PrP) and neuroligin1 (NLGN-1). Cells treated with …
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The Effects of Ethynodiol Diacetate on Epinephrine-Treated Glial-Derived Cells
… specific hormones, may play a role in preventing cellular damage following an ischemic event or brain injury. Astrocytes are specialized glial cells within the central nervous system that play roles in synapse development, blood flow regulation, extracellular homeostasis, synapse function, energy …
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Mapping the Landscape of Acquired Vulnerabilities in Ovarian Cancer
… microRNA (miRNA) screen in 16 ovarian cancer cell lines to annotate the functional landscape present in such a chaotic genetic background. miRNAs function as multigenic perturbations allowing for interrogation of maximal gene space with few experiments. This screen identified multiple miRNAs …
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
… every process of neuronal injury. Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. Inhibition of cathepsins does not rescue …
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Pulse electric field effect on cervical cancer cell: a plant based anti-cancer study
… which will be uploaded into cervical cancer cell with the aid of electrical pulses or electroporation technique to investigate on the anti-cancer mechanism. Electroporation parameters utilized in this study ranging from 200V/cm, 400V/cm, 600V/cm, 800V/cm, 1000V/cm of pulse amplitude, while …
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Modulation of Antibacterial Activity and Cytotoxicity in Amphipathic Cyclic Peptide [R4W4] Using Histidine Substitution
… eliciting a human embryonic kidney (HEK-293T) cell viability ≥ 80% as the concentration reached 15μM, beyond which cell viability sharply declines as low as 20 %. In previous studies, it was observed that substitution with histidine (H) into a tryptophan (W) and arginine (R) rich AMP resulted …
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Evaluation of cellular interactions with functionalized scaffolds for cardiovascular tissue engineering
… tissue engineering often do not have sufficient cell adhesion, thus the addition of biosignals is crucial. Surface modifications can be used to improve desired cell adhesion and proliferation. To covalently attach cell adhesion peptides/biosignals, synthetic hydrogel spacers are often used in an …
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Investigations on the Effects of Palmitate on Neuronal Cells
… podocytes, myocytes, and pancreatic islet cells. However, the effects of FAAs on neuronal cell function are not well characterized. In this study, mouse neuroblastoma cells from the Neuro-2a (N2a) cell line were treated with either bovine serum albumin (BSA) or different concentrations of …
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The protective role of tumour necrosis factor alpha in the heart
… towards a subsequent ischaemic insult in muscle cells. To test this and to delineate the downstream signalling cascades mediating this programme we developed classic PC protocols in adherent mature murine C2C12 myotubes and in human cardiac derived Girardi cell lines. The C2C12 myotubes were …
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