Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cell type specific regulation"”.
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Cell type-specific regulation of the chicken tyrosinase promoter
… coats of vertebrates, is synthesised by two main cell types: melanocytes and retinal pigment epithelial (RPE) cells. These two cell populations. which arise from distinct embryological origins, differ with respect to the rate at which they produce melanin and the ways in which they respond to …
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The Role of the Circadian Clock in the Paraventricular Nucleus of the Hypothalamus in Diurnal Energy Balance
… Maintained at the level of individual cells throughout the body, the circadian clock is necessary for driving tissue-specific temporal programs of energy balance. Though loss of the circadian transcription factor, BMAL1, in the paraventricular nucleus (PVN) of the hypothalamus has …
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Regulation of the Gene Encoding Thrombin-Activable Fibrinolysis Inhibitor in Non-Hepatic Cells
… of CPB2 mRNA (∆6+10) was described to be brain specific. This TAFI variant is reputed to possess a secretase-like activity that cleaves β-amyloid precursor protein to form β-amyloid, a process involved in the onset of Alzheimer's disease. In this thesis, we report the identification of CPB2 mRNA …
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Cell Size Control And Asymmetric Cell Fates In Start Of The Saccharomyces cerevisiae Cell Cycle
… mechanisms that couple the process of cell growth to cell division is one of the major challenges of modern cell biology. Saccharomyces cerevisiae (budding yeast) has been an important model organism to study the coupling between cell growth and cell division. The insights obtained from …
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Context-dependent activity of a pioneer transcription factor, ASCL1, in early development
Transitions from one cell type to another are fundamental to developmental biology and they require the concerted activity of transcription factors (TFs) to ensure the expression of the right genes at the right time. Some TFs, so-called pioneer TFs, direct cell identity by opening previously closed …
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Spatiotemporal control of gene expression in Caenorhabditis elegans
Cell-type specific regulation of transcription drives the production of the myriad of different cells generated during development. Profiling genome-wide gene expression landscapes in different tissues has improved our understanding of the physiological and pathological processes taking place …