Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"cell turnover"”.
-
Characterization of Stem Cell Turnover In A Living Epithelial Bilayer
… the renewal and replacement of old or dying cells while sustaining a functional barrier. Imbalance between cell production and elimination are hypothesized to underlie many pathological conditions. However, our knowledge of cell turnover within living tissues remains largely restricted to …
-
A mouse model for the pathogenesis of immunodeficiency virus infection
… constant by homeostatic mechanisms balancing cell gain and loss. These mechanisms eventually fail in HIV infection, which is characterized by progressive immune deficiency attributable to a slow but relentless depletion of CD4+ T cells, the main viral targets. HIV infection is also associated …
-
THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION
… capillary bed, to develop into the appropriate cell type. The neonatal rat pancreas undergoes a developmental β cell turnover that involves the apoptosis of immature β cells and their replacement with adult β cells. To further elucidate this mechanism and the potential role of the vascular …
-
Investigating Adult Stem Cell Lineage Specification in the Freshwater Flatworm Schmidtea mediterranea
Adult stem cells (ASCs) serve to facilitate tissue turnover during the lifespan of an organism. The goal of my research has been to deepen our understanding of how ASCs become specified towards differentiation to produce physiologically functional cell types. To this end, I have chosen to use the …
-
Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
… remain limited. Recent studies have found that cell-free DNA (cfDNA) released from dying neurons and glia can be detected in the bloodstream using cell-specific methylation patterns. A better understanding of remyelination-associated glial cell turnover dynamics may aid in the discovery of …
-
NEAR INFRARED SPECTROSCOPIC ASSESSMENT OF BONE WATER BINDING TO COLLAGEN AND MINERAL
… that other factors such as bone architecture, cell turnover and tissue composition influence bone quality. There is growing evidence that age related changes in bone water associated with collagen and/or mineral have a direct impact on bone mechanical competence and structural integrity. …
-
Investigating how Notch, and JAK/STAT Signaling Synergistically Regulate Intestinal Stem Cell Homeostasis Using Engineered Optogenetic Alleles
Stem cells are a class of undifferentiated cells that have the unique ability to give rise to a variety of specialized cell types during tissue development and growth. These cells communicate amongst one another by sending and receiving signals from multiple pathways that regulate cell fate …
-
Regulation of fate specification in stem cells of the planarian Schmidtea mediterranea
… mechanisms for producing a wide array of cell types. Neoblasts are stem cells of the planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription …
-
Experimental Models of Mycobacterial Replication and Killing in Macrophages
… carried out in our laboratory suggested that cell turnover [apoptosis and necrosis] within a granuloma may contribute to the control of mycobacterial infection. The experiments described here demonstrated that both apoptosis [Fas-mediated] and necrosis [perforin-induced] of infected human …
-
Expression Analysis of the Regenerating Utricle Sensory Epithelia : From Macroarrays to Parsing Pathways
… epithelium from each organ is made up of hair cells and supporting cells. These hair cells are necessary for the detection of sound in the cochlea and for the detection of movement and acceleration in the utricle. The chicken sensory epithelia is of great research interest as it possesses the …
-
A blood exchange method to study circulation kinetics of tumor cells in the blood
Blood is an essential compartment for tumor cell trafficking. In solid epithelial-derived tumors, blood serves as the major vehicle for metastasis, whose principal cell is the circulating tumor cell (CTC). These cells originate from the primary tumor and are shed at low concentrations into the …
-
The Influence of Estrogen Signaling on Male Reproduction in Medaka (Oryzias latipes)
… alterations observed include increased germ cell apoptosis, decreased germinal epithelium and thickening of the interstitium. These morphologic changes were highly associated with gene expression changes. A pathway analysis of the differentially expressed genes emphasized genes and pathways …
-
ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
Programmed cell death, or apoptosis, is critical for normal developmental processes that involve cell turnover including embryogenesis and development and function of the immune system. It is preceded by classical changes in cell morphology, driven by biochemical changes including caspase …
-
The role of death-associated protein kinase in endothelial apoptosis under fluid shear stress
<p>Endothelial cells are the interface between hemodynamic fluid flow and vascular tissue contact. They actively translate physical and chemical stimuli into intracellular signaling cascades which in turn regulate cell function, and endothelial dysfunction leads to inflammation and diseased …