Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"cell to cell communication"”.
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A nucleic acid-based bacterial message export system for cell-to-cell communication
Communication within natural systems of eukaryotes and prokaryotes typically entails message transmission between and among cells via small-molecule messengers being funneled from the sender to the receiver cell. Nucleic acids are rarely used as extracellular messengers due to their labile nature …
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INVESTIGATING THE ROLE OF DEFECTIVE CELL TO CELL COMMUNICATION MECHANISMS IN RETT SYNDROME PATHOGENESIS
… and calcium signaling, but they also fail to adequately sustain neuronal growth and activity. Although understanding the causative mechanisms could guide the development of novel and effective therapeutic strategies, they remain largely unknown to date. This study explores the impact of …
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Identifying the molecular components that matter: a statistical modelling approach to linking functional genomics data to cell physiology
… measured in single experiments, have contributed to reshape biological investigations. One of the most important issues in the analysis of the generated large datasets is the selection of relatively small sub-sets of variables that are predictive of the physiological state of a cell or tissue. In …
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Biochemical Assay Optimization and Computational Screening Efforts to Identify Potential LuxS Inhibitors
… of bacterial gene expression in response to cell population. System two QS is regulated by the small signaling molecule autoinducer-2 (AI-2) and is implicated in the infectious behaviors of various bacterial species. AI-2 is biosynthesized from <em>S-</em>ribosylhomocysteine (SRH) by the …
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Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection
… of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the sensory …
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Synthesis of S-Ribosyl-L-homocysteine and Analogs Modified at the Homocysteine-C3 Position
<p>Quorum sensing (QS) is a process of bacterial cell-to-cell communication that conveys population density information in order to coordinate gene expression to produce synchronized behaviors. QS regulates the expression of virulence genes in many species of bacteria; hence, the manipulation of QS …
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Cell penetrating peptide for ocular drug delivery
… results in the loss of sharp central vision due to breakdown of the blood retinal barrier (BRB), unregulated blood vessel proliferation and vascular leak, particularly into the macula of the retina. The inflammatory and hypoxic pathology of neovascular AMD has been linked to uncontrolled …
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Neuropeptidomics Across Metazoan Life
… acting as neurotransmitters, neuromodulators and peptide hormones, play pivotal roles in a variety of physiological processes, such as learning and memory, sleeping, pain, and anxiety. To understand how neuropeptides work in the human brain can be extremely challenge; fortunately, most …
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A translational approach to understanding cellular responses to vascular injury
Appropriate control of cell proliferation and migration is essential for maintaining open arteries after vascular injury. Connexin 43 is a channel protein that facilitates cell to cell communication and regulates cell proliferation as well as migration, yet it's role in vascular cell types is …
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Integrated functional anlaysis of quorum-sensing in the rice pathogenic bacterium Burkholderia glumae
Quorum sensing (QS) is a cell-to-cell communication mechanism that allows bacterial cells to collectively behave like a multicellular organism. It regulates the expression of toxoflavin, one of the major virulence factors of the rice pathogen, Burkholderia glumae. The QS system of B. glumae is …
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Communication at the Cellular Level: Discovery and Application
Cell-cell communication is essential to the functioning of all multicellular organisms, and understanding these critical processes can help solve current biomedical problems. As a demonstration of the utility of this approach, existing knowledge of the interactions between B cells and T cells in …
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Biochemical Evaluation of SRH Analogs as Potential LuxS Inhibitors
<p>Quorum sensing in bacteria is a process of cell-to-cell communication facilitated by small molecules called autoinducers. Interspecies quorum sensing is facilitated by the autoinducer AI-2. The enzyme LuxS catalyzes the formation of AI-2 from <em>S</em>-ribosyl homocysteine (SRH) in a wide …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
Mitochondria provide the main energy required for cardiac excitation-contraction coupling via aerobic oxidative phosphorylation (OXPHOS) process. Accumulation of reactive oxygen species (ROS), by-products of mitochondrial respiration, within dysfunctional mitochondria results in the activation of …
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VANESA - A bioinformatics software application for the modeling, visualization, analysis, and simulation of biological networks in systems biology applications
This work presents VANESA, a powerful and easy-to-use modeling software. The software application is laid out to support scientists from the natural sciences in the modeling and analysis of biological systems to better understand biological processes. Therefore, it combines different fields of …
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DEVELOPMENT OF SINGLE-CELL MASS SPECTROMETRY TOOLS TO INVESTIGATE METABOLIC REORGANIZATION DURING EARLY EMBRYOGENESIS
Measurement of metabolism in single cells holds the potential to advance our understanding of fundamental biological processes during cell differentiation and development. However, to characterize the metabolic state of single cells, further technological advances are still required. This …
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Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
… sites in patients with CRCs are liver and lung. To confirm the diagnosis of metastatic CRC (mCRCs) and to classify mCRCs, tumor biopsy of a suspected metastasis is often required. The consensus molecular subtype (CMS) classification which is based on gene expression profiles of CRC tumor …
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Mechanisms of ionic current changes underlying rhythmic activity recovery after decentralization
… a variety of functions, from learning and memory to rhythmic motor activity such as breathing. To perfectly function in a living organism, rhythm-generating networks have to combine the capability of producing a stable output with the plasticity needed to adapt to the changing demands of the …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
… "molecular switches" relaying signals from the cell membrane to the rest of the cell in a highly regulated manner. However, Ras signaling is aberrantly activated in a majority of human cancers either through an activating mutation or by activation or overexpression of upstream or downstream …
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Biochemical and molecular characterization of methyl-accepting chemotaxis proteins from Bacillus subtilis
… for the behavioral response by organisms to environmental stimuli. The movement of bacteria toward various chemical substances depends upon the ability of the organism to detect perturbations within the environment. A transmembrane signalling system mediates these behavioral changes by …
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Development of fluorescence lifetime imaging microscopy techniques for analysis of single extracellular vesicles
Extracellular vesicles (EVs) make up a variety of μm and sub-μm phospholipid membrane-bound particles released by cells. EVs have recently become an intense topic of interest as more is learned about their many purposes, such as their function in cell-to-cell communication in diseases such as …
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