Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"cell therapies"”.
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Design of multi-functional hydrogel for cell therapies
… investigated as encapsulation devices for cell transplantation therapies, as they provide structural stability and protection against harsh chemical and mechanical stimuli, and host immune system. In addition, chemical moieties, mechanical stiffness, and minerals presented in hydrogels act …
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Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies
… including vaccines, engineered tissues, and cell therapies. Biomaterials enable a range of functionalities such as localized delivery, sustained release, and responsiveness. In the context of cell therapies, biomaterials can protect encapsulated cells from immune attack while allowing for …
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Subclonal Evolution of Chronic Lymphocytic Leukemia After Allogeneic T Cell Therapies
… chronic lymphocytic leukemia after allogeneic T-cell therapies</strong></p> <p>Haven Garber, MD</p> <p>Advisory Professor: Jeffrey Molldrem, MD</p> <p>Intratumoral genetic heterogeneity describes the molecular differences among subclones within a tumor and is a major barrier to effective therapy …
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The Characterization of T-Cell Manufacturing For Adoptive T-Cell Therapies
<p>Adoptive T-cell therapy using genetically modified T cells has emerged as a potential therapeutic option for several malignancies. Central to the production of the cellular therapy is the manufacturing using a stimulation, genetic engineering, and expansion methodology. Within this framework, …
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Engineering human hepatic organoids for in vitro liver modeling and implantable cell therapies
… but methods to expand primary hepatic cells in vitro while supporting their phenotype and function remain elusive. Organoid culture has successfully grown dozens of otherwise difficult-to-culture primary cells in 3D, generating valuable biological models and offering a new source of …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… intensive chemotherapy standard of care regimen. Cell therapies have shown great success against hematologic malignancies but face several challenges including treatment-related toxicities and human-leukocyte antigen (HLA) matching. Natural killer (NK) cells and gamma delta (γδ) T cells offer …
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The use of biomaterials for stem cell therapies to prevent myocardial damage post-infarct
This thesis employed a stem cell encapsulating hydrogel patch to increase the amount of beneficial soluble factors that are delivered to the surface of damaged heart tissue following a myocardial infarction. While current medical practices to address the immediate aftermath of a myocardial …
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Efficacy of Antibody and T cell Therapies for Highly Mutable Viruses like Human Immunodeficiency
… of the proteome that could be targeted by T cells has led to interest in passive immunotherapies and therapeutic vaccines as promising methods for treating chronic infection. However, the feasibility of creating a sufficiently powerful therapy remains uncertain. In this work, we develop a …
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Building blocks for regenerative medicine : vascularized models and immunomodulation to engineer hepatic cell therapies
… these challenges: hepatocyte (liver parenchymal cell) sourcing and immune compatibility. The main hurdle in primary human hepatocyte sourcing is the loss of regenerative potential of the cells ex vivo.
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Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy
… the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. Epilepsy is a multifactorial neurological disorder affecting 1% of the population. Available pharmacological therapies are merely …
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Exploring factors that influence trust in non-standard stem cell therapies among patients with musculoskeletal conditions
Although stem cell interventions (SCIs) may offer some therapeutic potential, the development of regulatory frameworks for their safe clinical application remains a significant challenge. As the regulation of these innovative therapies is still being developed, it is crucial to examine the factors …
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Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive Cell Therapies with Multiple Myeloma
… (MM), a cancer of bone marrow-resident plasma cells, is the 2nd-most common hematological malignancy. However, despite the advent of immunotherapies like chimeric antigen receptor (CAR) -T cells, which gained FDA approval in March 2021, relapse is nearly universally inevitable. The bone marrow …
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Macrophage-hitchhiking Anisotropic Microparticles for Therapeutic and Diagnostic Applications
Cell therapies represent a major paradigm shift of biotechnology in medicine due to its transformative potential in treating previously incurable diseases. A variety of cells have been applied for cell therapies, including stem cells, tissue-specific cells, and hematopoietic cells. Particularly, …
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Human Embryonic stem cell-derived A9 dopaminergic neurons as a model and therapy for Parkinson's disease
… options for those living with PD, all current therapies centre around providing symptomatic relief for patients. Therefore, there is a need for the identification of disease-modifying or disease slowing treatments in PD. Embryonic stem cells can reliably generate standardised populations of A9 …
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Generation of a novel pan-cancer chemokine receptor-modified CAR-T cell therapy directed towards nfP2X7
CAR-T cell therapy has achieved significant success in the treatment of multiple haematological malignancies. However, solid cancers present challenges such as tumour antigen heterogeneity and complex mechanisms of immune evasion that have limited the translation of CAR-T cell therapies from …
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Engineering Liver and Cardiac Models for Drug Development and Regenerative Medicine
… as well as fundamental investigations into stem cell behavior and cell-cell interactions. Tissue engineering is also increasingly used for regenerative medicine and for modeling of metabolism and physiology. However, there are material challenges associated with cellular organization, tissue …
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Towards a Single Bio-molecule Detector Based on CMOS Nanofluidic Platform
… is a core component of the function of many cell therapy products: It affects the tissue repair capacity of induced Pluripotent Stem Cells (iPSCs) and Mesenchymal Stem cells (MSCs) and the tumorigenicity of Chimeric Antigen Receptor (CAR) T-cell therapies. Ideally, we would be able to …
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RNA sensing and programming platforms for mammalian synthetic Biology
The field of synthetic biology aims to control cellular behavior using programmable gene circuits. Generally these gene circuits sense molecular biomarkers, process these inputs and execute a desired calculated response. This is especially relevant for gene and cell therapies where integrating …
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Overcoming Challenges in Cellular Therapies: A Systems Engineering Approach for Equitable Access
Cellular and gene therapies have ushered in a new era of medical treatment, promising cures previously thought unattainable. Technologies like CRISPR/Cas9 enable precise genome manipulation, yet challenges persist in therapy delivery, prompting the rise of ex vivo approaches. Despite the promise of …
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United States stem cells research boundaries
… particularly in fields such as molecular and cellular biology in which the materiality of research renders the process of replication and validation more complex. Scientific infrastructure has many interconnecting elements such as the ability to exchange material used in experiments, the …
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