Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"cell targeting"”.
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Modular Nanoparticles for Selective Cell Targeting
… with tunable surface properties for selective cell targeting. Specifically, polyelectrolyte complexes composed of heparin (Hep, a growth factor binding glycosaminoglycan) and poly-L-lysine (PLL, a homopolymeric lysine) were prepared via a pulse sonication method. The Hep/PLL core NPs were …
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Selective cell targeting with light-absorbing particles
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.
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Ellipsoidal polyaspartamide polymersomes with enhanced cell-targeting ability
… display enhanced binding efficiency with target cells, but this has not yet been experimentally validated. We hypothesized that hydrophilic polymer chains coupled to vesicle-forming polymers would result in ellipsoidal polymersomes. In addition, ellipsoidal polymersomes modified with cell …
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Selective in vivo metabolic labeling for cell targeting and immune regulation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Treatment of Systemic Lupus Erythematosus by Nutrition and Dendritic Cell Targeting
… MRL/lpr mice, tRA administration reduced immune cell numbers in the secondary lymphoid organs and improved glomerulonephritis. However, circulating autoantibodies and inflammation in renal tubulointerstitium and other organs were increased. The detrimental effects of tRA were not present in MRL …
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More ins than outs for tumour cell targeting: Combining molecular imaging probes and cell-penetrating peptides
Contains fulltext : 241556.pdf (Publisher’s version ) (Open Access)
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Development of a click chemistry approach for cancer cell targeting and evaluating the effect of protein corona on active targeting yield
The routine approach for targeting nanoparticle delivery vehicles to cancer cells is by incorporating targeting ligands (e.g. antibodies or aptamers) to the surface of nanoparticles (NPs). Although targeting ligands are known to interact with specific receptors in the membranes of cancer cells, …
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Conjugation of Biological and Carbon Nanoparticles For Applications In Electronics and Cell Imaging
… extensively studied for applications in cancer cell targeting, imaging, and drug delivery. Carbon-based quantum dots, or Selah Dots, were conjugated with fluorescent dye molecules to improve their fluorescent signal, and cell targeting ligands were conjugated to improve the cell targeting …
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Developing Low Fouling Peptides and Zwitterionic Materials for Biomedical Applications
… peptide sequences (such as RGD for specific cell targeting) without the need for complex chemical conjugation. In addition to rational and biomimetic peptide design, a combinatorial screening method was explored to facilitate the testing of thousands of peptide sequences for low protein …
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A dendrimer-based prodrug for use in an anti-cancer nanocell
… treatment. For example, it is well known that cells of varying tumor types have unique molecular markers and cell-surface receptors - fingerprints of sorts - that set cancerous cells apart from healthy cells. Furthermore, the tumor microenvironment has been explored to the point that its unique …
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Radiobiology of normal rat lung in Boron Neutron Capture Therapy
… therapy that utilizes biochemical tumor cell targeting and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal rat lung in BNCT and measured the relative biological …
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On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.
Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive …
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The Functional Contribution of Adaptive Immunity In The Biology of Pancreatic Cancer and Therapeutic Targeting of Oncogenic Kras
… The Biology Of Pancreatic Cancer And Therapeutic Targeting Of Oncogenic Kras</p> <p>Krishnan K. Mahadevan M.B.B.S*</p> <p>Advisory professor: Dr. Raghu Kalluri</p> <p>Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer related deaths in the …
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A technical and economic evaluation of novel pH-responsive core-shell nanoparticles : delivering innovation from laboratory to market
… into the cytosolic or nuclear compartments of cells. Members of the Irvine laboratory have developed a novel pH-responsive core-shell nanoparticle system that can achieve efficient and non-cytotoxic drug delivery into the cytosol. Another advantage is that the shell can be easily modified to …
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Developing canine osteosarcoma and human non-small cell lung cancer PDX models to study immunotherapies targeting canine and human T cells
In the last decade, therapies targeting one's own immune system (immunotherapies) have proven to be effective in extending the quality of life and lifespan for a variety of patients with lung, breast, and prostate cancer. However, patients where their cancer is either unresponsive or become …
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Ex vivo culture of patient tissue and examination of gene delivery
… cancer due to its potential for selective tumour cell targeting. The greatest challenge gene delivery vectors face is the ability to safely and efficiently deliver genes into target cells. The overall objectives of this thesis are to evaluate the efficacy of various gene delivery methods in a …
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EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors
… of Pc 4 in biocompatible block-copolymer micelles, (2) Modify micelle surface with EGFR-specific ligands and investigate cancer cell targeting of the surface-modified micelles in vitro, and, (3) Investigate targeted PDT effects on SCC cell lines in vitro and suitable animal models in vivo …
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
… as a vector for vaccine development and cancer cell-targeting therapy. Despite the importance of studying poxvirus effects on the human immune system, reports of the direct interactions between poxviruses and primary human leukocytes (PHLs) are limited. We studied the specific molecular events …
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Syntheses of biocompatible luminescent nanocrystals for visible and short-wave infrared imaging applications
… (QY), narrow photoluminescence spectra, and excellent photostability. However, challenges remain to be solved to transfer the as-synthesized hydrophobic QD to aqueous solutions while maintaining the high QY and a compact size. This study involves the design and synthesis of a novel ligand that …
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Engineering Lipid Nanoparticle-Mediated Delivery of Nucleic Acids to Lymphoid Organs and Immune Cells
… to lymphoid organs such as the spleen and immune cells including T cells and neutrophils. Phospholipids containing phosphoethanolamine (PE) head groups likely increase endosomal escape due to their fusogenic properties. Additionally, it was found that negatively charged phospholipids drive spleen …
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