Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 538 for “"cell survival"”.
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The Tumor Microenvironment Regulates Retinoblastoma Cell Survival
… pediatric tumors. Early intervention increases survival rates up to 95% in developed countries; being survival rates associated to socio-economic status. Despite the high survival rates in developed countries, preservation of the eye and vision are continuing challenges in the management of Rb. …
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Essentiality of Mitochondrial Genome Integrity in Cell Survival
… EXOG downregulation in HeLa and HCT116 p53 +/+ cells by siRNA transfection caused significant accumulation of SSBs/repair intermediates in the mitochondrial genome, depolarization of mitochondrial membrane potential, increase in ROS generation, and cell death. Increase in Annexin V positive cell …
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Molecular mechanisms of mammalian cell survival and differentiation
Cellular and developmental processes are regulated by extracellular and intracellular signals that are mediated by networks of signaling pathways. In recent years, microRNAs have also emerged as a class of critical modulators of the same processes. For my thesis studies, I focused on regulatory …
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Investigating Novel Targets to Inhibit Cancer Cell Survival
… treatments. One reason for this is cancer cells are able to survive through adaptation to their environment and aberrantly activated growth signaling. As such, developing new therapies that overcome these hurdles are necessary to combat cancer. Previous work in our laboratory using RNA …
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Apoptotic cells promote circulating tumor cell survival and metastasis
… and especially following cytotoxic therapy, cell death of both tumor and stromal cells is widespread. Despite clinical observations that high levels of apoptotic cells correlate with poorer patient outcomes, the physiological effects of dying cells on tumor progression remain incompletely …
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Novel Cancer Therapeutics, the Generation of ROS, and Cell Survival
The impact of Ad.mda-7 on the survival of renal cell carcinoma lines (RCC), primary renal epithelial cells, glioblastoma multiforme lines (GBM), and primary rodent astrocytes is unknown. The present studies examine whether the GST fusion protein, GST-MDA-7, and the adenovirus, Ad.mda-7, altered the …
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The Role of Gene Expression Noise In Mammalian Cell Survival
… major challenge contributing to this problem is cellular heterogeneity. Even in the same environment, cells with identical genomes can display cell-to-cell differences in gene expression, also known as gene expression noise. Gene expression noise can vary in magnitude in a population or in …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… that are enriched in metastatic breast cancer cells and predicted to significantly alter protein function. The pro-metastatic role of one of these mutations—a nonsense alteration that yields a truncated pannexin-1 (PANX1 1-89) plasma membrane megachannel subunit—was functionally characterized. …
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Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
<p>In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. Additionally, cancer cells exposed to these stresses are more resistant to therapies, more likely to metastasize and often are …
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TTBK2 and Primary Cilia are Required for Purkinje Cell Survival
… cilia can be found on almost every mammalian cell, including neurons and glia. Tau Tubulin Kinase 2 (TTBK2) is a critical regulator of the building of primary cilia, and mutations within Ttbk2 cause the adult-onset, neurodegenerative disease, Spinocerebellar Ataxia type 11 (SCA11). SCA11 is …
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Mathematical Models of Some Signaling Pathways Regulating Cell Survival and Death
In a multi-cellular organism, cells constantly receive signals on their internal condition and surrounding environment. In response to various signals, cells proliferate, move around or even undergo suicide. The signal-response is controlled by complex molecular machinery, understanding of which is …
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Role of protein kinase C isoforms in human breast tumor cell survival
… 12 unique isoforms that function in a variety of cellular processes including proliferation, apoptosis, differentiation and carcinogenesis. The contribution of individual PKC isoforms to these processes is largely unexplored. The purpose of this study is to identify specific PKC isoforms that …
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Rapid turnover of McL-1 couples translation to cell survival and apoptosis
… to the induction of apoptosis by various cell stimuli including inhibition of PI 3-kinase/Akt survival signaling, viral infection, lipopolysaccharide, and tumor necrosis factor alpha. However, the mechanism by which translation inhibition promotes apoptosis has not been established. This …
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DNA-damage-mediated remodeling of normal and tumor microenvironments modulates cell survival
… of genotoxic compounds that induce cancer cell death via well-established DNA damage response signaling networks. While modern chemotherapeutic regimens can be curative, chemotherapeutic drug resistance remains a major clinical problem. This drug resistance can be cancer cell intrinsic or …
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Genetic and molecular analysis of the C.elegans cell survival gene ced-9
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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The Role of Igf-1 and Il-4 in Myeloid Progenitor Cell Survival
The development of myeloid progenitor cells requires paracrine growth factors to mediate the proliferation, differentiation and survival of these cells. In this thesis, we demonstrate that IGF-I and IL-4, a cytokine produced by activated T-lymphocytes, enhance the survival of CSF-stimulated …
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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… (iNKT) and mucosa-associated invariant T (MAIT) cells, which participate in early host defense against pathogens and tumors, remains poorly understood. In this thesis, I leveraged multiple established methods with which to induce psychological stress in mice. I demonstrate that TH1- and TH2-type …
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