Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 117 for “"cell surface receptors"”.
-
Quantitative Analysis of the Spatial and Temporal Organization of Cell Surface Receptors
Appendix B contains a previously published article, which is referenced below as a related citation.
-
Investigation of in-situ nanoimprinting of cell surface receptors: potential of a novel technique in biomarker research
… tremendously among patients and disease stages. Cell surface receptors, proteins that are located at the cell surface and deliver external signals into the cell, are a significant group of easily-detectable biomarkers. Along with the detection of particular biomarkers related to a disease, …
-
Real Time PCR-Based Infectivity Assay and Characterization of Cell Surface Receptors for Turkey Hemorrhagic Enteritis Virus
… vaccine propagated in live turkeys, and a cell culture-based vaccine generated in RP19 cells. The only laboratory-adapted tests for assessing the titers of these vaccines are agar gel immunodiffusion test and cell culture endpoint dilution, respectively. The assays suffer from low …
-
Evaluation of Peptides and Peptide–Doxorubicin Conjugates Designed and Synthesized for Targeting Triple-Negative Breast Cancer via Cell-Surface Receptors
… of harm to surrounding healthy tissues and cells that often lead to serious side effects. Current strategies being explored to circumvent this issue aim to refine delivery of chemotherapeutic agents specifically to tumor sites, which may be achieved via conjugation of these agents to …
-
Resolving Signal Transduction in Complex Biological Environments
Cell surface receptors reside in complex biological environments along with their numerous extracellular ligands to transduce information across the membrane bilayer. These receptors regulate major functions including cell proliferation, facilitation of neuronal transmission, cell growth and …
-
Experimental and modeling studies of endosomal sorting using the epidermal growth factor/receptor system in fibroblasts
… mediated endocytosis is the process by which cells internalize ligands which have specifically interacted with cell surface receptors. Cells have the ability to sort internalized ligands and their receptors to lysosomes for degradation, to recycle them back to the plasma membrane, or to sort …
-
Regulation of Neuronal Polarity by Wnt Signaling
… that function in many developmental processes. Cell surface receptors, including the Frizzleds (Fz), ROR, and RYK families of proteins, bind Wnts to activate a number of downstream pathways. Wnts act redundantly to regulate the anteroposterior polarity of mechanosensory neurons ALM and PLM in C. …
-
Defining interactions between Mycobacterium leprae and Langerhans cells
… of the intricate interactions with innate immune cells has made advances in some cell subsets but is limited in others leaving an incomplete picture of the disease. These gaps limit advances in disease management. M. leprae is an obligate, intracellular pathogen that grows preferentially between …
-
Computational Studies of Autocrine Ligand Binding
Autocrine ligand secretion and binding to cell surface receptors regulate cell behavior in a number of important physiological functions. At the same time, some pathological conditions such as the unmitigated growth of tumors can also act through this type of stimulation. Interpretation of …
-
The recognition of lipopolysaccharides present in Gram-negative bacteria by receptors of the immune system
… requires efficient communication between immune cells and this is achieved partly through specific cell surface receptors, some of which are involved in bacterial recognition. One virulent pathogen that binds cell surface receptors and triggers immune cells to overproduce pro-inflammatory …
-
Proliferative and survival pathways in oesophageal cancer
Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does not significantly enhance patient survival. A better understanding of proliferative and survival …
-
Extracellular Interaction Screening Using CRISPR Activation
Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for …
-
Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
… signal transduction kinases mediating intracellular responses to extracellular events. They are involved in mediating complex cellular events including, cell differentiation, cell proliferation, and cell death. Extracellular mitogens or the binding of other ligands to cell-surface receptors …
-
Mannose and Lipopolysaccharide Receptors on the Surface of Granular Hemocytes from the Crayfish <em>Procambarus clarkii</em>.
… indicated that the binding of FITC-LPS to these cells is impaired by initial incubation with LPS. Prior treatment of hemocytes with horseradish peroxidase, a mannose rich glycoprotein, decreased their capacity to bind mannose. Mannan had no inhibitory effect on the binding of either ligand. Mixed …
-
Purinergic Receptors in the Circumvallate Papillae of Rats
<p>P2X2 receptors and P2Y4 receptors are ATP-activated cell surface receptors that gate movement of K+, Na+, and Ca2+. We used immunocytochemistry for P2X2 and P2Y4 receptors as well as taste cell type markers to learn if P2X2 immunoreactivity (IR) is present in nerve processes in close apposition …
-
CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
The regulated expression of cell surface receptors is essential for cellular homeostasis and defective in disease states. Receptor regulation is particularly important as receptor internalization limits the duration and intensity of substrate signaling. Interferon-γ (IFN-γ), a critical antiviral …
-
Glucose-Induced Apoptosis of Schwann Cells In vitro
The loss of Schwann cells in the peripheral nerves is thought to be responsible for the pathologies associated with diabetic neuropathy. As diabetes causes increased extracellular glucose levels, glycosylation or non-enzymatic glycation of cell surface receptors may interfere with normal signaling …
-
Syntaxin 6- and Microtubule- Mediated Intracellular Trafficking Contributes to Golgi and Nuclear Translocation of Egfr
… trafficking. Recent evidence shows that these cell surface receptors translocate from cell surface to different cellular compartments, including the Golgi, mitochondria, endoplasmic reticulum (ER), and the nucleus to regulate physiological and pathological functions. Although some trafficking …
-
A dendrimer-based prodrug for use in an anti-cancer nanocell
… treatment. For example, it is well known that cells of varying tumor types have unique molecular markers and cell-surface receptors - fingerprints of sorts - that set cancerous cells apart from healthy cells. Furthermore, the tumor microenvironment has been explored to the point that its unique …
-
Development of mass spectrometry based technologies for quantitative cell signaling phosphoproteomics : the epidermal growth factor receptor family as a model system
Ligand binding to cell surface receptors initiates a cascade of signaling events regulated by dynamic phosphorylation on a multitude of pathway proteins. Quantitative features, including intensity, timing, and duration of phosphorylation of particular residues play a role in determining cellular …
Page 1 of 6