Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"cell surface receptor"”.
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Developmental models with cell surface receptor densities defining morphological position
New receptor-based models for pattern formation and regulation in multicellular biological systems are proposed. The test organism for the mathematical modelling is a fresh-water polyp, hydra. Another model is applied to describe the growth of tumour along linear or tubular structure. Models are …
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Understanding the molecular mechanism on cell surface receptor interaction of helicobacter pylori vacuolation cytotoxin
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01
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Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein
… since the normal biological function of PrPc, a cell surface-anchored glycoprotein predominantly expressed in neuronal cells, and the cellular processes in which this protein is involved remain obscure. Recently, the human 37 kDa laminin receptor precursor (LRP), which represents the precursor of …
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Elucidation of a Macrophage Cell Surface Receptor With Specificity for Exogenous Aromatic Hapten-Protein Antigens and Effects on Antigen Uptake and Processing
… of antigen uptake was dependent on the extent of receptor crosslinkage at the cell surface as well as on the accessibility of the ligand groups. Determination of the ligand-binding specificity of the macrophage receptor suggested preference for aromatic ligands like phenylalanine, …
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Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv
… antibodies (Ab) can internalize in a variety of cells. An anti-nucleic acid antibody, murine 3D8 single chain variable fragment (scFv) Ab, has been known to be an internalizing antibody that enters the cells by caveolae/lipid-raft-mediated endocytosis. However, cell surface receptor for 3D8 scFv …
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Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection
… of T lymphocytes is determined by the specific cell surface receptor composition present. A technologic tool that could resolve these receptor differences could detect T lymphocyte activation and thus provide a diagnostic modality for AR. Raman spectroscopy (RS), a laser-based technology that is …
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Establishing the Role of DC-SIGN and Glycoprotein H for KSHV Entry in B Lymphocytes
… Kaposi Sarcoma (KS), two rare B cell- based lymphomas; Primary effusion lymphoma, Multicentric Castleman’s disease and a recently characterized inflammatory disorder called KSHV-associated inflammatory cytokine syndrome(KICS). Unfortunately, all of the diseases associated with …
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Molecular basis of Fce receptor: IgE interactions
… molecules of IgE bound to their high-affinity cell surface receptor FceRI. This interaction initiates intracellular signalling starting a cascade of events resulting in cellular degranulation and the release of inflammatory mediators. Many present treatments for these conditions act at this …
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Quantitative isoforrm profiling & isoform convergence
… alternative splicing is sensitive to changes in cellular states including malignancy. We present a new paradigm by which to quantitatively study the alternative splicing of any molecule through the presented methods of quantitative exon profiling and quantitative isoform profiling which take …
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Investigating The Role of Cd109 In Pancreatic Ductal Adenocarcinoma
… on a cohort of four patient derived PDAC cell populations and our data shows a cell surface receptor CD109 to be a common vulnerability, the biologic role of which in PDAC is yet unstudied and largely unknown. We hypothesized that CD109 expression provides PDAC cells with a survival …
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Pancreatic Ribonuclease Functions As An Epidermal Growth Factor Receptor Ligand Independently of Its Enzyme Activity and Contributes to Cetuximab Resistance
… has also been suspected to have an unidentified cell surface receptor. Epidermal growth factor receptor (EGFR), a well-characterized receptor tyrosine kinase is an effective therapeutic target in multiple cancer types. However, clinical trials targeting EGFR have not demonstrated improved …
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Interrogating the molecular mechanism of signal transduction in the TGF-β receptor superfamily
A major unanswered question in cellular signalling is how binding of an extracellular ligand to its cell-surface receptor triggers activation of an intracellular signalling cascade to achieve a physiological response. TGF-β signalling is central to many physiological processes, from embryonic …
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Poly(Arginine) Derived Cancer-Targeting Peptides for the Development of a Cancer-Targeted Gene Therapy Approach in HepG2 Liver Cancer Cells
… selection of a suitable biomarker, typically a cell surface receptor overexpressed or selectively localized on the surface of cancer cells but not on normal tissues. This biomarker forms the basis of a cancer targeting approach, in which high affinity and specific binding ligands (<em>e.g</em>. …
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Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance
… factor known to signal in a variety of mammalian cells through the IGF-I cell surface receptor (IGF-IR). A unique feature of the IGF-I system is the regulation of this binding by soluble IGF binding proteins. Recent studies from our laboratory show that there is a pH dependence in the association …
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Exploring the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Phosphoinositide and Cytoskeletal Assembly Dynamics and the Pathobiology of Pulmonary Arterial Hypertension
Background: The regulation of intracellular trafficking between the trans-Golgi network (TGN) and plasma membrane (PM) is vital for protein secretion and growth factor signaling, which involves recycling and PM localization of cell surface receptors. These processes depend on the cytoskeleton and …
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Cellular and Molecular Mechanisms of Retinal Neuron Spatial Patterning
<p>During development, cell-cell recognition events mediate crucial steps in the formation of organized cellular patterns critical for tissue function. In the nervous system, cell recognition cues guide migrating neurons during development to appropriate terminal locations and sculpt their …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… of neuronal circuits. Thus, understanding the cellular and molecular mechanisms leading to the precise assembly of neuronal circuits is a major focus of developmental neurobiology. The structural organization and specific connectivity of neuronal circuits arises from a series of morphological …
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Bioconjugate Strategies for Antisense Therapeutic Delivery to Glioblastoma Stem Cells
… The delivery of antisense therapeutics to target cells presents a significant challenge due to the many barriers a nucleic acid must face in order to reach the cytoplasm where it exerts its effects. In this thesis, I explored multiple strategies for delivery of AONs and siRNAs, focusing on …
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Analysis of a Proposed Cell Binding Site on Caenorhabditis Elegans Collagen Type Iv
… provides structural support and regulation of cell migration and binding. C. elegans body wall muscle col IV consists of two alpha 1 chains and one alpha 2 chain. The human col IV molecule has a cell binding site (CBS) composed of aspartate (D) on each alpha 1 chain and arginine (R) on the …
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The tissue factor-factor VII(a) complex in blood coagulation
… by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation of factor VII (FVII) to FVIIa. Upon vascular injury, TF is exposed to the bloodstream where it comes into contact with FVII(a). The …
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