Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cell surface localization"”.
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Biochemical and Functional Analyses of PANX1 Variants
… impact on the channel function of PANX1 at the cell surface. From this, we discovered a novel tyrosine phosphorylation site at Tyr150, that when disrupted via a missense mutation resulted in hypo-glycosylation and a greater capacity to traffic to the cell-surface and enhanced dye uptake. We have …
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Exploring the role of aneuploidy in phenotypic variability
… leads to an endocytic defect that impacts the cell surface localization of hexose transporters, which ultimately leads to variability in uptake of hexose sugars and thus variability in induction of the GAL1-10 promoter.
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Tissue specific regulation of the high density lipoprotein (HDL) receptor, scavenger receptor Class B, Type I (SR-BI) by the scaffold protein PDZK1
… at its C-terminus) might interact with other cellular components to influence hepatic SR-BI expression. This thesis explores the role of PDZK1's structural features in the PDZK1-dependent regulation of hepatic SR-BI through the hepatic expression of PDZK1 and various truncation and point …
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Characterization and Functional Analysis of Astrotactin 2 Reveals a Role for Endocytosis in Glial-guided Neuronal Migration
… neurons of the cerebellar circuitry, granule cells and Purkinje cells, develops by glial-guided migrations that position these cell types in specific neuronal layers. Classical EM studies and real time imaging of the migration of granule neurons along glial fibers established the mode of …
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Metadherin Functions As A Laminin Receptor That Is Essential For Metastasis and Is Associated With Poor Survival In Osteosarcoma
… expression of MTDH in a panel of osteosarcoma cell lines. In parallel experiments we used MTDH-specific shRNA to reduce endogenous MTDH expression, and blocked cell surface MTDH by anti-MTDH antibodies. The impact of MTDH inhibition was assessed in vitro using transwell migration assays and …
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Impaired N-Glycosylation Processing Impacts Neuronal Function
… the WT AB strain. The confocal images suggest cell morphology of CaP neurons are lacking branches. The third and final aim of this study examined the fully glycosylated (Wt) or the un-glycosylated (N220/229Q) Kv3.1b proteins in two different neuroblastoma (NB) cell lines. The NB_1 cell line …