Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1055 for “"cell surface"”.
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Vascular endothelial cell-surface proteoglycans
… linked by disulfide bonding was isolated from cell layers of normal ("cobblestone") bovine vascular endothelial cells in culture. Treatment of the parent molecules with dithiothreitol caused their complete cleavage and permitted the subsequent separation of the larger and smaller subunits on …
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Archaeal signal peptides and cell surface structures
… stable mutant displaying pili as the sole cell surface appendage, providing the unique opportunity to closely study this structure without the interference of flagella. Here, purification and characterization of the archaeal pili is described for the first time in any archaeon. A putative …
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Cell surface interactions of Coxsackie A9 virus
… panel of different RGDX variants and a number of cell lines not previously used in CAV9 research b) the significance of possible interactions between CAV9 and HSPG in infection. Several CAV9 variants were tested in a panel of 8 different cell lines. Infection in each cell line was observed to …
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Serial protein pairs in cell/surface adhesion
… offers the first systematic investigation of cell/surface adhesion mediated through protein/protein bonds in series. Cell adhesion and migration are facilitated through protein/protein bonds in series established when membrane-bound proteins simultaneously interact with extracellular proteins …
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Engineering cytokine immunotherapies via cell surface targeting
Cancer immunotherapy targets immune cells to trigger a highly specific, long-lasting anti-tumor response. With the clinical success of immune checkpoint blockade and the development of promising next-generation agents, immunotherapy is steadily growing as a key pillar of the oncology clinic …
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Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment
… treatment outcomes. The rITs were targeting cell surface biomarkers, Trophoblast cell surface antigen 2 (TROP2) and mesothelin (MSLN), which are overexpressed in cervical cancer cells. Targeting TROP2 and MSLN presents a promising therapeutic approach. The study aimed to develop novel …
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DNA-based Artificial Mimics of Cell-surface Machinery
The plasma membrane of cells has evolved to mediate a broad array of functionalities critical to life, such as molecular trafficking, signal transduction, motility, adhesion and communication. These functionalities are often reliant on highly sophisticated membrane-anchored nano-machines, and …
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The study of cell surface components on Porphyromonas gingivalis
… was to clone genes encoding, and characterize cell surface components of P. gingivalis as potential virulence factors of this organism. AP. gingivalis ATCC 33277 genomic library was generated. Clones were screened by biological assays for haemagglutination and proteolytic activity, and by a …
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Novel Cell Surface Anchoring Mechanism Of Prokaryotic Secreted Protein
The microbial cell surface is decorated with a variety of protein structures that play important roles in key cellular processes such as providing cell stability, facilitating interactions between cells, and interacting with the environment. One important feature of the biosynthesis of these …
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Cell surface analysis of the basidiomycete yeast cryptococcus neoformans
Cell surface properties of the basidiomycete yeast Cryptococcus neoformans were investigated with a combination of novel and well proven approaches. Non-specific cell adhesion forces, as well as exposed carbohydrate and protein moieties potentially associated with specific cellular interaction, …
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Cell surface display in biomedical applications and biofuels production
Cell surface display allows peptides or proteins to be expressed on the cell exterior as fusions to natural host anchoring motifs. It is a powerful technique with a myriad of applications in protein engineering, environmental bioremediation, biocatalysis, as well as vaccine and therapeutics …
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Functional particles for controlled release and cell surface engineering
… emerged as the new generation of molecular and cell carriers for a series of biomedical applications. These polymer vesicles typically present as hollow spheres that contain a hydrophilic core surrounded by a hydrophobic membrane, each of which can be loaded with a wide array of small and large …
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Chemical Biology Tools to Study Bacterial Cell Surface Glycans
Cell surface glycans are ubiquitous and serve as the first point of contact between a cell and the surrounding environment. Many of the carbohydrate-mediated interactions that occur at this interface regulate key signaling processes such as cell-cell recognition, communication, and adhesion. …
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Identification of cell surface assembly mutants in Saccharomyces cerevisiae
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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Characterization of Metastasis-Associated Cell Surface Glycoproteins in Prostate Cancer
… process involving extravasation of a cancer cell subsequent invasion and expression at a site distal to the primary tumors. Cell surface glycoproteins play pivotal roles as recognition molecules in a range of cell communication and adhesion events. Aberrant cell surface glycosylation has been …
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Role of VimA in Cell Surface Biogenesis in Porphyromonas gingivalis
… mechanisms and interactions of this protein in surface biogenesis, transport and membrane integrity. The focus of our work was to clarify the role of VimA on cell surface biogenesis. We were able to show via TEM and AFM that there were significant differences between the v<em>imA</em>-defective …
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NOVEL PEPTOID TARGETING CELL SURFACE VIMENTIN FOR LUNG CANCER TREATMENT
… serum and chemical stability, tissue and cell permeability, and reduced immunogenicity. The economical and straightforward synthesis of peptoids allows the development of peptoid libraries with millions of diversities. These bead-displayed peptoid libraries can be synthesized very rapidly …
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Developmental models with cell surface receptor densities defining morphological position
… for pattern formation and regulation in multicellular biological systems are proposed. The test organism for the mathematical modelling is a fresh-water polyp, hydra. Another model is applied to describe the growth of tumour along linear or tubular structure. Models are defined in the form of …
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Characterisation of the cell-surface localised palmitoyl acyl transferase, DHHC5
… and C- termini. This coupled with differing sub-cellular localisations is thought to be the basis of substrate specificity.<br/><br/>DHHC5 is a cell surface localised DHHC-PAT which has a characteristic, long cytoplasmic C-tail which is responsible for substrate recruitment. DHHC5 has an …
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