Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 331 for “"cell specific"”.
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Toward Cell-Specific Nanoparticle Delivery Systems
… in experimental design and optimization for cell-specific applications. To address this, NOCAP (Nanoparticle Optimization and Cell Affinity Prediction) was developed, a computational framework designed to (i) predict the affinities between nanoparticles and gene expression signatures of …
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Cell-Specific Inhibition of Interferon Production by Rotavirus
… differences in rotaviral infection of two human cell lines; the intestinal (Caco-2) and the alveolar basal (A549) epithelial cells. Our findings confirmed the potential ability of the virus to establish extra-intestinal infection in A549 cells. Furthermore, our results showed up-regulated IFNs …
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Identification of Undifferentiated Human Embryonic Stem Cell-Specific Genes
Embryonic stem cells are derived from mammalian blastocysts and self-renewal and maintain pluripotency, an ability to differentiate into all types of somatic and germ cells. Recent reports showed that several genes such as Pou5F1 (Oct4, Oct3/4), Sox2, Nanog, LIN28, KLF4, Myc(c-Myc) maintained a …
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Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
… By discovering novel therapeutics that target specific disease processes within specific diseased cells, while leaving healthy cells unaltered, we can improve the lives of millions of cancer sufferers and their families. A therapeutic's window of efficacy can be measured by the therapeutic …
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Dynamics of Germ Cell Specific Stable Transcriptional Complexes in Xenopus Oocytes
… is particularly true of genes that determine cell fate; for example, Asc1-1 leads to neural differentiation and MyoD for muscle. In early development, different genes need to be activated in sequence by appropriate transcription factors. It is commonly believed that a transcription factor has …
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Alkyladenine DNA glycosylase (Aag)-dependent cell-specific responses to alkylating agents
… environments and can cause damage to all cellular components, including our DNA. If left unrepaired, methylated DNA can cause mutations, cell death, and disease, such as cancer and neurodegeneration. The majority of DNA lesions caused by methylating agents are repaired by the base excision …
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Elucidation of the regulatory mechanism of SWEET11 phloem parenchyma cell-specific expression
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Cell-specific roles for CASK in the pathology of Optic Nerve Hypoplasia
… we know little about the genetic, molecular, or cellular mechanisms underlying ONH. A previous study described ONH in a cohort of patients with mutations in CASK, an X-linked gene with established roles in neural development and synaptic function. I have demonstrated that heterozygous deletion of …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
… number of necrotic toes, or skeletal muscle cell size. We conclude that FAV and FA excision in CD-1 mice generate a comparable severity of hindlimb ischemia. In other words, FAV ligation is no more severe than FA ligation. These findings provide valuable information for researchers when …
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Investigating the Cell-specific Mechanisms That Drive Sex Differences During Neuropathic Pain Development
… has placed microglia, the resident immune cells of the central nervous system, at the forefront of male-specific mechanisms that mediate chronic pain plasticity. Recently, efforts have been made to design studies aimed at dissecting female specific mechanisms in pain plasticity. Evidence …
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Cerebellar granule cell-specific deletion of the AMPA receptor subunit GluR-D gene
Ionotrope Glutamatrezeptoren spielen eine entscheidende Rolle bei physiologischen und pathophysiologischen Prozessen im Gehirn. Die Rezeptoren werden in drei Untergruppen eingeteilt aufgrund ihrer pharmakologischen Eigenschaften und ihrer Sequenzähnlichkeit. Diese sind die …
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Analysis of genes involved in cell-specific control of programmed cell death in Caenorhabditis elegans
Programmed cell death is an important process regulating cell number in the development of all animals. Two genes, ces-1 and ces-2 control programmed cell death in a subset of developing neurons in C. elegans. To understand how ces-1 and ces-2 might act to regulate programmed cell death, we have …
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Analysis of the Structure and Cell-Specific Transcription of the Bovine Parathyroid Hormone Gene (Micrococcal Nuclease)
Two EcoR I restriction fragments containing PTH gene sequences were isolated from a partial bovine library prepared using EcoR I cleaved high molecular weight bovine DNA and lambda phage charon 30 as a cloning vector. Restriction and sequence analyses of the two fragments indicate that they are …
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Investigating the T cell-specific role of Interleukin-4 receptor alpha (IL-4Rα) in tuberculosis (TB)
… on the ability of the host to mount a robust T cell response. The main effector T cells which contribute to protection in TB include T helper (Th) Th1 and Th17 T cells. The Th2 response, associated with IL-4Rα mediated signalling, remains largely overlooked in TB. The role of IL-4Rα in TB …
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
… lymphadenopathies, carcinomas, and lymphomas. B cells are the main latent reservoir of gammaherpesviruses. A central question is how B cell signaling regulates viral gene expression during establishment and reactivation from latency. The MHV68 M2 gene, a proposed functional analog of the EBV …
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Effects of an Endothelial Cell-specific PAR2 Knockout on Endothelium-dependent and -independent Relaxation of Mouse Arteries
… receptor expressed on endothelial cells (EC), is a target in chronic inflammatory diseases. Understanding the functions of EC PAR2 will inform the development of PAR2-based therapeutics to treat endothelial dysfunction, a characteristic of cardiovascular and metabolic diseases. In …
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Multi-omics mapping of the stress load on cell-specific glucocorticoid-dependent cascades in Tau brain pathology
Το χρόνιο ψυχολογικό στρες και τα υψηλά επίπεδα γλυκοκορτικοειδών (GC) αποτελούν εκλυτικούς παράγοντες της εγκεφαλικής παθολογίας στη νόσο του Αλτσχάιμερ, ωστόσο οι μοριακοί μηχανισμοί που διαμεσολαβούν σε αυτή την επίδραση του στρες/GC σε διαφορετικούς πληθυσμούς εγκεφαλικών κυττάρων παραμένουν …
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Testing the reliability and selectivity of different bone-cell-specific Cre- expressing mouse models for studying bone cell metabolism
… a requirement for reliable, high-fidelity, and specific transgenic expression of the Cre recombinase. This study focuses on the reliability of different bone cell specific Cre models in the Cre/loxP system. In this study, DMP1-Cre transgenic mouse which has a transgene driven by DMP1 promotor …
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The rickettsial effector Sca4 has a conserved interaction with host clathrin and a tick cell specific role in infection
Intracellular bacterial pathogens secrete effectors to manipulate the host cell environment, create a hospitable niche, and promote infection. While many effectors interact with specific host machinery to perform a single distinct function, some effectors are capable of interaction with multiple …
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Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… RNAs influence key biological processes such as cell differentiation, apoptosis, and oxidative stress, which are essential for maintaining cochlear function and protecting auditory sensory cells. Changes in microRNA expression have been linked to different types of hearing loss, including …
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